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95 related items for PubMed ID: 19475539

  • 1. Pharmacokinetics of sertindole and its metabolite dehydrosertindole in rats and characterization of their comparative pharmacodynamics based on in vivo D2 receptor occupancy and behavioural conditioned avoidance response.
    Bundgaard C, Larsen F, Kreilgaard M, Brennum LT, Olsen CK.
    Biopharm Drug Dispos; 2009 May; 30(4):209-20. PubMed ID: 19475539
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  • 2. Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics.
    Olsen CK, Brennum LT, Kreilgaard M.
    Eur J Pharmacol; 2008 Apr 28; 584(2-3):318-27. PubMed ID: 18325493
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  • 3. The effect of erythromycin on the CYP3A component of sertindole clearance in healthy volunteers.
    Wong SL, Cao G, Mack RJ, Granneman GR.
    J Clin Pharmacol; 1997 Nov 28; 37(11):1056-61. PubMed ID: 9505999
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  • 11. Sertindole, in contrast to clozapine and olanzapine, does not disrupt water maze performance after acute or chronic treatment.
    Didriksen M, Kreilgaard M, Arnt J.
    Eur J Pharmacol; 2006 Aug 07; 542(1-3):108-15. PubMed ID: 16806167
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  • 12. Predicting the dopamine D2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic-pharmacodynamic modeling.
    Huang C, Wang Z, Liu L, Liu X, Dong J, Xu Q, Zhang B, Miao L.
    Xenobiotica; 2019 Feb 07; 49(2):143-151. PubMed ID: 29334326
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  • 13. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats.
    Johnson M, Kozielska M, Pilla Reddy V, Vermeulen A, Li C, Grimwood S, de Greef R, Groothuis GM, Danhof M, Proost JH.
    Pharm Res; 2011 Oct 07; 28(10):2490-504. PubMed ID: 21647790
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  • 14. The dopamine stabilizers (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine [(-)-OSU6162] and 4-(3-methanesulfonylphenyl)-1-propyl-piperidine (ACR16) show high in vivo D2 receptor occupancy, antipsychotic-like efficacy, and low potential for motor side effects in the rat.
    Natesan S, Svensson KA, Reckless GE, Nobrega JN, Barlow KB, Johansson AM, Kapur S.
    J Pharmacol Exp Ther; 2006 Aug 07; 318(2):810-8. PubMed ID: 16648369
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  • 15. Pharmacokinetics and concentration-effect analysis of intravenous RGD891, a platelet GPIIb/IIIa antagonist, using mixed-effects modeling (NONMEM).
    Zannikos PN, Rohatagi S, Jensen BK, DePhillips SL, Rhodes GR.
    J Clin Pharmacol; 2000 Oct 07; 40(10):1129-40. PubMed ID: 11028252
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  • 16. Pharmacokinetic-pharmacodynamic modeling of the hydroxy lerisetron metabolite L6-OH in rats: an integrated parent-metabolite model.
    Ortega F, Quintana A, Suárez E, Lukas JC, Jauregizar N, de la Fuente L, Lucero ML, Gonzalo A, Orjales A, Calvo R.
    Pharm Res; 2005 Nov 07; 22(11):1769-82. PubMed ID: 16158214
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  • 17. Effects of sertindole on sleep-wake states, electroencephalogram, behavioral patterns, and epileptic activity of rats.
    Coenen AM, Ates N, Skarsfeldt T, van Luijtelaar EL.
    Pharmacol Biochem Behav; 1995 Nov 07; 51(2-3):353-7. PubMed ID: 7667352
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  • 18. Modeling of sertindole pharmacokinetic disposition in healthy volunteers in short term dose-escalation studies.
    Wong SL, Granneman GR.
    J Pharm Sci; 1998 Dec 07; 87(12):1629-31. PubMed ID: 10189278
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  • 19. Dissociation between in vivo occupancy and functional antagonism of dopamine D2 receptors: comparing aripiprazole to other antipsychotics in animal models.
    Natesan S, Reckless GE, Nobrega JN, Fletcher PJ, Kapur S.
    Neuropsychopharmacology; 2006 Sep 07; 31(9):1854-63. PubMed ID: 16319908
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  • 20. Pharmacokinetics of sertindole in healthy young and elderly male and female subjects.
    Wong SL, Cao G, Mack RJ, Granneman GR.
    Clin Pharmacol Ther; 1997 Aug 07; 62(2):157-64. PubMed ID: 9284851
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