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92 related items for PubMed ID: 19479253

  • 1. Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
    Nathwani SM, Butler S, Meegan MJ, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Cancer Chemother Pharmacol; 2010 Jan; 65(2):289-300. PubMed ID: 19479253
    [Abstract] [Full Text] [Related]

  • 2. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
    Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Cancer Chemother Pharmacol; 2010 Aug; 66(3):585-96. PubMed ID: 20020128
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  • 3. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
    Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM.
    Mol Pharmacol; 2006 Jul; 70(1):60-70. PubMed ID: 16571652
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  • 4. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
    McElligott AM, Maginn EN, Greene LM, McGuckin S, Hayat A, Browne PV, Butini S, Campiani G, Catherwood MA, Vandenberghe E, Williams DC, Zisterer DM, Lawler M.
    Cancer Res; 2009 Nov 01; 69(21):8366-75. PubMed ID: 19826055
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  • 5. Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
    Mc Gee MM, Campiani G, Ramunno A, Fattorusso C, Nacci V, Lawler M, Williams DC, Zisterer DM.
    J Pharmacol Exp Ther; 2001 Jan 01; 296(1):31-40. PubMed ID: 11123359
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  • 10. The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.
    Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM.
    Int J Oncol; 2013 Jan 01; 42(1):239-46. PubMed ID: 23135704
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  • 11. A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
    Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y.
    J Mol Med (Berl); 2008 Apr 01; 86(4):457-69. PubMed ID: 18270678
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  • 12. Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents.
    Zisterer DM, McGee MM, Campiani G, Ramunno A, Fattorusso C, Nacci V, Lawler M, Williams DC.
    Biochem Soc Trans; 2001 Nov 01; 29(Pt 6):704-6. PubMed ID: 11709059
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  • 13. Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
    Bright SA, Campiani G, Deininger MW, Lawler M, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2010 Jul 01; 80(1):31-8. PubMed ID: 20206141
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  • 14. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
    Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM.
    Oncol Rep; 2005 Nov 01; 14(5):1357-63. PubMed ID: 16211309
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  • 15. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
    Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2014 Feb 15; 87(4):611-24. PubMed ID: 24406249
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  • 16. Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
    Mc Gee MM, Greene LM, Ledwidge S, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM.
    J Pharmacol Exp Ther; 2004 Sep 15; 310(3):1084-95. PubMed ID: 15143129
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  • 17. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.
    Bright SA, Greene LM, Greene TF, Campiani G, Butini S, Brindisi M, Lawler M, Meegan MJ, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2009 Feb 01; 77(3):310-21. PubMed ID: 19014913
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  • 18. Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.
    Staedler D, Chapuis-Bernasconi C, Dehmlow H, Fischer H, Juillerat-Jeanneret L, Aebi JD.
    J Med Chem; 2012 Jun 14; 55(11):4990-5002. PubMed ID: 22533316
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  • 19. Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.
    Shanab K, Schirmer E, Knafl H, Wulz E, Holzer W, Spreitzer H, Schmidt P, Aicher B, Müller G, Günther E.
    Bioorg Med Chem Lett; 2010 Jul 01; 20(13):3950-2. PubMed ID: 20537894
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  • 20. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6.
    Mc Gee MM, Hyland E, Campiani G, Ramunno A, Nacci V, Zisterer DM.
    FEBS Lett; 2002 Mar 27; 515(1-3):66-70. PubMed ID: 11943196
    [Abstract] [Full Text] [Related]

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