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Journal Abstract Search

181 related items for PubMed ID: 19487250

  • 1. A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding.
    Nakayama S, Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, Okazaki O.
    Drug Metab Dispos; 2009 Sep; 37(9):1970-7. PubMed ID: 19487250
    [Abstract] [Full Text] [Related]

  • 2. Predictability of idiosyncratic drug toxicity risk for carboxylic acid-containing drugs based on the chemical stability of acyl glucuronide.
    Sawamura R, Okudaira N, Watanabe K, Murai T, Kobayashi Y, Tachibana M, Ohnuki T, Masuda K, Honma H, Kurihara A, Okazaki O.
    Drug Metab Dispos; 2010 Oct; 38(10):1857-64. PubMed ID: 20606003
    [Abstract] [Full Text] [Related]

  • 3. Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity.
    Takakusa H, Masumoto H, Yukinaga H, Makino C, Nakayama S, Okazaki O, Sudo K.
    Drug Metab Dispos; 2008 Sep; 36(9):1770-9. PubMed ID: 18508880
    [Abstract] [Full Text] [Related]

  • 4. In vitro evaluation of the potential for drug-induced toxicity based on (35)S-labeled glutathione adduct formation and daily dose.
    Miyaji Y, Makino C, Kurihara A, Suzuki W, Okazaki O.
    Bioanalysis; 2012 Feb; 4(3):263-9. PubMed ID: 22303830
    [Abstract] [Full Text] [Related]

  • 5. In vitro cytotoxicity assay to evaluate the toxicity of an electrophilic reactive metabolite using glutathione-depleted rat primary cultured hepatocytes.
    Fujimoto K, Kishino H, Yamoto T, Manabe S, Sanbuissho A.
    Chem Biol Interact; 2010 Dec 05; 188(3):404-11. PubMed ID: 20846519
    [Abstract] [Full Text] [Related]

  • 6. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N, Makino C, Murayama N.
    Chem Res Toxicol; 2007 Mar 05; 20(3):455-64. PubMed ID: 17309281
    [Abstract] [Full Text] [Related]

  • 7. A toxicity risk index, an index for warning idiosyncratic drug toxicity.
    Morimoto M, Samizo K, Ohta S, Mizuma T.
    J Pharm Sci; 2013 Sep 05; 102(9):3447-50. PubMed ID: 23666879
    [Abstract] [Full Text] [Related]

  • 8. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
    Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1345-410. PubMed ID: 21702456
    [Abstract] [Full Text] [Related]

  • 9. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
    Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA.
    Chem Res Toxicol; 2009 Feb 19; 22(2):357-68. PubMed ID: 19146377
    [Abstract] [Full Text] [Related]

  • 10. Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction.
    Bauman JN, Kelly JM, Tripathy S, Zhao SX, Lam WW, Kalgutkar AS, Obach RS.
    Chem Res Toxicol; 2009 Feb 19; 22(2):332-40. PubMed ID: 19161298
    [Abstract] [Full Text] [Related]

  • 11. Metabolites and safety: What are the concerns, and how should we address them?
    Smith DA, Obach RS.
    Chem Res Toxicol; 2006 Dec 19; 19(12):1570-9. PubMed ID: 17173370
    [Abstract] [Full Text] [Related]

  • 12. Benchmarking in vitro covalent binding burden as a tool to assess potential toxicity caused by nonspecific covalent binding of covalent drugs.
    Dahal UP, Obach RS, Gilbert AM.
    Chem Res Toxicol; 2013 Nov 18; 26(11):1739-45. PubMed ID: 24164572
    [Abstract] [Full Text] [Related]

  • 13. Effect of plasma protein binding on in vitro-in vivo correlation of biliary excretion of drugs evaluated by sandwich-cultured rat hepatocytes.
    Fukuda H, Ohashi R, Tsuda-Tsukimoto M, Tamai I.
    Drug Metab Dispos; 2008 Jul 18; 36(7):1275-82. PubMed ID: 18388177
    [Abstract] [Full Text] [Related]

  • 14. Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
    Obach RS, Kalgutkar AS, Soglia JR, Zhao SX.
    Chem Res Toxicol; 2008 Sep 18; 21(9):1814-22. PubMed ID: 18690722
    [Abstract] [Full Text] [Related]

  • 15. Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement.
    Hallifax D, Houston JB.
    Drug Metab Dispos; 2006 Apr 18; 34(4):724-6; author reply 727. PubMed ID: 16552024
    [No Abstract] [Full Text] [Related]

  • 16. The binding of drugs to hepatocytes and its relationship to physicochemical properties.
    Austin RP, Barton P, Mohmed S, Riley RJ.
    Drug Metab Dispos; 2005 Mar 18; 33(3):419-25. PubMed ID: 15616151
    [Abstract] [Full Text] [Related]

  • 17. Identification of in vitro protein biomarkers of idiosyncratic liver toxicity.
    Gao J, Ann Garulacan L, Storm SM, Hefta SA, Opiteck GJ, Lin JH, Moulin F, Dambach DM.
    Toxicol In Vitro; 2004 Aug 18; 18(4):533-41. PubMed ID: 15130611
    [Abstract] [Full Text] [Related]

  • 18. Towards more efficient testing strategies--analyzing the efficiency of toxicity data requirements in relation to the criteria for classification and labelling.
    Nordberg A, Rudén C, Hansson SO.
    Regul Toxicol Pharmacol; 2008 Apr 18; 50(3):412-9. PubMed ID: 18334276
    [Abstract] [Full Text] [Related]

  • 19. Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.
    Kilford PJ, Gertz M, Houston JB, Galetin A.
    Drug Metab Dispos; 2008 Jul 18; 36(7):1194-7. PubMed ID: 18411401
    [Abstract] [Full Text] [Related]

  • 20. A semi-automated method for measuring the potential for protein covalent binding in drug discovery.
    Day SH, Mao A, White R, Schulz-Utermoehl T, Miller R, Beconi MG.
    J Pharmacol Toxicol Methods; 2005 Jul 18; 52(2):278-85. PubMed ID: 16125627
    [Abstract] [Full Text] [Related]

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