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Journal Abstract Search

161 related items for PubMed ID: 19500982

  • 1. Optimization of piperidin-4-yl-urea-containing melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Reducing hERG-associated liabilities.
    Berglund S, Egner BJ, Gradén H, Gradén J, Morgan DG, Inghardt T, Giordanetto F.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4274-9. PubMed ID: 19500982
    [Abstract] [Full Text] [Related]

  • 2. Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.
    Berglund S, Egner BJ, Gradén H, Gradén J, Morgan DG, Inghardt T, Giordanetto F.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4268-73. PubMed ID: 19500979
    [Abstract] [Full Text] [Related]

  • 3. Bicyclo[3.1.0]hexyl urea melanin concentrating hormone (MCH) receptor-1 antagonists: impacting hERG liability via aryl modifications.
    McBriar MD, Guzik H, Shapiro S, Xu R, Paruchova J, Clader JW, O'neill K, Hawes B, Sorota S, Margulis M, Tucker K, Weston DJ, Cox K.
    Bioorg Med Chem Lett; 2006 Aug 15; 16(16):4262-5. PubMed ID: 16753297
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.
    Kasai S, Kamata M, Masada S, Kunitomo J, Kamaura M, Okawa T, Takami K, Ogino H, Nakano Y, Ashina S, Watanabe K, Kaisho T, Imai YN, Ryu S, Nakayama M, Nagisa Y, Takekawa S, Kato K, Murata T, Suzuki N, Ishihara Y.
    J Med Chem; 2012 May 10; 55(9):4336-51. PubMed ID: 22490048
    [Abstract] [Full Text] [Related]

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  • 6. Lead optimization of melanin concentrating hormone receptor 1 antagonists with low hERG channel activity.
    Judd AS, Souers AJ, Kym PR.
    Curr Top Med Chem; 2008 May 10; 8(13):1152-7. PubMed ID: 18782010
    [Abstract] [Full Text] [Related]

  • 7. Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
    Zhang M, Tamiya J, Nguyen L, Rowbottom MW, Dyck B, Vickers TD, Grey J, Schwarz DA, Heise CE, Haelewyn J, Mistry MS, Goodfellow VS.
    Bioorg Med Chem Lett; 2007 May 01; 17(9):2535-9. PubMed ID: 17329101
    [Abstract] [Full Text] [Related]

  • 8. Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.
    Judd AS, Souers AJ, Wodka D, Zhao G, Mulhern MM, Iyengar RR, Gao J, Lynch JK, Freeman JC, Falls HD, Brodjian S, Dayton BD, Reilly RM, Gintant G, Limberis JT, Mikhail A, Leitza ST, Houseman KA, Diaz G, Bush EN, Shapiro R, Knourek-Segel V, Hernandez LE, Marsh KC, Sham HL, Collins CA, Kym PR.
    Bioorg Med Chem Lett; 2007 Apr 15; 17(8):2365-71. PubMed ID: 17350253
    [Abstract] [Full Text] [Related]

  • 9. Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity.
    Kameda M, Kobayashi K, Ito H, Miyazoe H, Tsujino T, Nakama C, Kawamoto H, Ando M, Ito S, Suzuki T, Kanno T, Tanaka T, Tahara Y, Tani T, Tanaka S, Tokita S, Sato N.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4325-9. PubMed ID: 19487123
    [Abstract] [Full Text] [Related]

  • 10. Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
    Chen X, Mihalic J, Fan P, Liang L, Lindstrom M, Wong S, Ye Q, Fu Y, Jaen J, Chen JL, Dai K, Li L.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):363-6. PubMed ID: 22123324
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.
    Rowbottom MW, Vickers TD, Dyck B, Grey J, Tamiya J, Zhang M, Kiankarimi M, Wu D, Dwight W, Wade WS, Schwarz D, Heise CE, Madan A, Fisher A, Petroski R, Goodfellow VS.
    Bioorg Med Chem Lett; 2006 Sep 01; 16(17):4450-7. PubMed ID: 16814542
    [Abstract] [Full Text] [Related]

  • 12. Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition.
    Mihalic JT, Fan P, Chen X, Chen X, Fu Y, Motani A, Liang L, Lindstrom M, Tang L, Chen JL, Jaen J, Dai K, Li L.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3781-5. PubMed ID: 22542010
    [Abstract] [Full Text] [Related]

  • 13. Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics.
    McBriar MD, Guzik H, Xu R, Paruchova J, Li S, Palani A, Clader JW, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar B, Weig B.
    J Med Chem; 2005 Apr 07; 48(7):2274-7. PubMed ID: 15801820
    [Abstract] [Full Text] [Related]

  • 14. 4-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1).
    Lim CJ, Kim SH, Lee BH, Oh KS, Yi KY.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):427-30. PubMed ID: 22137790
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and evaluation of 4-alkoxy-[1'-cyclobutyl-spiro(3,4-dihydrobenzopyran-2,4'-piperidine)] analogues as histamine-3 receptor antagonists.
    Becknell NC, Dandu RR, Lyons JA, Aimone LD, Raddatz R, Hudkins RL.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):186-9. PubMed ID: 22153342
    [Abstract] [Full Text] [Related]

  • 16. Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment?
    Högberg T, Frimurer TM, Sasmal PK.
    Bioorg Med Chem Lett; 2012 Oct 01; 22(19):6039-47. PubMed ID: 22954736
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.
    Lim CJ, Kim JY, Lee BH, Oh KS, Yi KY.
    Bioorg Med Chem Lett; 2013 Mar 15; 23(6):1736-9. PubMed ID: 23411080
    [Abstract] [Full Text] [Related]

  • 18. Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
    Lau JF, Jeppesen CB, Rimvall K, Hohlweg R.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5303-8. PubMed ID: 16908150
    [Abstract] [Full Text] [Related]

  • 19. Recent progress in the discovery of melanin-concentrating hormone 1-receptor antagonists.
    Johansson A.
    Expert Opin Ther Pat; 2011 Jun 15; 21(6):905-25. PubMed ID: 21492020
    [Abstract] [Full Text] [Related]

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