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Journal Abstract Search

189 related items for PubMed ID: 19576866

  • 1. Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase.
    Zhu L, Zhou B, Chen X, Jiang H, Shao J, Yen Y.
    Biochem Pharmacol; 2009 Nov 01; 78(9):1178-85. PubMed ID: 19576866
    [Abstract] [Full Text] [Related]

  • 2. Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay.
    Shao J, Zhou B, Zhu L, Bilio AJ, Su L, Yuan YC, Ren S, Lien EJ, Shih J, Yen Y.
    Biochem Pharmacol; 2005 Feb 15; 69(4):627-34. PubMed ID: 15670581
    [Abstract] [Full Text] [Related]

  • 3. 2,2'-Bipyridyl-6-carbothioamide and its ferrous complex: their in vitro antitumoral activity related to the inhibition of ribonucleotide reductase R2 subunit.
    Nocentini G, Federici F, Franchetti P, Barzi A.
    Cancer Res; 1993 Jan 01; 53(1):19-26. PubMed ID: 8416745
    [Abstract] [Full Text] [Related]

  • 4. Syntheses and antitumor activities of potent inhibitors of ribonucleotide reductase: 3-amino-4-methylpyridine-2-carboxaldehyde-thiosemicarba-zone (3-AMP), 3-amino-pyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) and its water-soluble prodrugs.
    Li J, Zheng LM, King I, Doyle TW, Chen SH.
    Curr Med Chem; 2001 Feb 01; 8(2):121-33. PubMed ID: 11172670
    [Abstract] [Full Text] [Related]

  • 5. In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone).
    Barker CA, Burgan WE, Carter DJ, Cerna D, Gius D, Hollingshead MG, Camphausen K, Tofilon PJ.
    Clin Cancer Res; 2006 May 01; 12(9):2912-8. PubMed ID: 16675588
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones.
    Krishnan K, Prathiba K, Jayaprakash V, Basu A, Mishra N, Zhou B, Hu S, Yen Y.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6248-50. PubMed ID: 18976907
    [Abstract] [Full Text] [Related]

  • 7. Molecular mechanisms of drug resistance involving ribonucleotide reductase: hydroxyurea resistance in a series of clonally related mouse cell lines selected in the presence of increasing drug concentrations.
    Choy BK, McClarty GA, Chan AK, Thelander L, Wright JA.
    Cancer Res; 1988 Apr 15; 48(8):2029-35. PubMed ID: 2832057
    [Abstract] [Full Text] [Related]

  • 8. Overexpression of ribonucleotide reductase in transfected human KB cells increases their resistance to hydroxyurea: M2 but not M1 is sufficient to increase resistance to hydroxyurea in transfected cells.
    Zhou BS, Hsu NY, Pan BC, Doroshow JH, Yen Y.
    Cancer Res; 1995 Mar 15; 55(6):1328-33. PubMed ID: 7882331
    [Abstract] [Full Text] [Related]

  • 9. Inhibitors of ribonucleotide reductase. Comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones.
    Cory JG, Cory AH, Rappa G, Lorico A, Liu MC, Lin TS, Sartorelli AC.
    Biochem Pharmacol; 1994 Jul 19; 48(2):335-44. PubMed ID: 8053929
    [Abstract] [Full Text] [Related]

  • 10. Characterization of mouse leukemia L1210 cells resistant to the ribonucleotide reductase inhibitor 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone.
    Cory AH, Sato A, Thompson DP, Cory JG.
    Oncol Res; 1996 Jul 19; 8(10-11):449-56. PubMed ID: 9114437
    [Abstract] [Full Text] [Related]

  • 11. The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.
    Yu Y, Suryo Rahmanto Y, Hawkins CL, Richardson DR.
    Mol Pharmacol; 2011 Jun 19; 79(6):921-31. PubMed ID: 21389104
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of malignant cell growth by 311, a novel iron chelator of the pyridoxal isonicotinoyl hydrazone class: effect on the R2 subunit of ribonucleotide reductase.
    Green DA, Antholine WE, Wong SJ, Richardson DR, Chitambar CR.
    Clin Cancer Res; 2001 Nov 19; 7(11):3574-9. PubMed ID: 11705879
    [Abstract] [Full Text] [Related]

  • 13. Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies.
    Tsimberidou AM, Alvarado Y, Giles FJ.
    Expert Rev Anticancer Ther; 2002 Aug 19; 2(4):437-48. PubMed ID: 12647987
    [Abstract] [Full Text] [Related]

  • 14. In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase.
    Shao J, Zhou B, Zhu L, Qiu W, Yuan YC, Xi B, Yen Y.
    Cancer Res; 2004 Jan 01; 64(1):1-6. PubMed ID: 14729598
    [Abstract] [Full Text] [Related]

  • 15. A Ferrous-Triapine complex mediates formation of reactive oxygen species that inactivate human ribonucleotide reductase.
    Shao J, Zhou B, Di Bilio AJ, Zhu L, Wang T, Qi C, Shih J, Yen Y.
    Mol Cancer Ther; 2006 Mar 01; 5(3):586-92. PubMed ID: 16546972
    [Abstract] [Full Text] [Related]

  • 16. Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.
    Finch RA, Liu M, Grill SP, Rose WC, Loomis R, Vasquez KM, Cheng Y, Sartorelli AC.
    Biochem Pharmacol; 2000 Apr 15; 59(8):983-91. PubMed ID: 10692563
    [Abstract] [Full Text] [Related]

  • 17. Redox property of ribonucleotide reductase small subunit M2 and p53R2.
    Liu X, Xue L, Yen Y.
    Methods Mol Biol; 2008 Apr 15; 477():195-206. PubMed ID: 19082948
    [Abstract] [Full Text] [Related]

  • 18. Circular dichroism and magnetic circular dichroism studies of the active site of p53R2 from human and mouse: iron binding and nature of the biferrous site relative to other ribonucleotide reductases.
    Wei PP, Tomter AB, Røhr AK, Andersson KK, Solomon EI.
    Biochemistry; 2006 Nov 28; 45(47):14043-51. PubMed ID: 17115699
    [Abstract] [Full Text] [Related]

  • 19. Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.
    Popović-Bijelić A, Kowol CR, Lind ME, Luo J, Himo F, Enyedy EA, Arion VB, Gräslund A.
    J Inorg Biochem; 2011 Nov 28; 105(11):1422-31. PubMed ID: 21955844
    [Abstract] [Full Text] [Related]

  • 20. Structurally dependent redox property of ribonucleotide reductase subunit p53R2.
    Xue L, Zhou B, Liu X, Wang T, Shih J, Qi C, Heung Y, Yen Y.
    Cancer Res; 2006 Feb 15; 66(4):1900-5. PubMed ID: 16488986
    [Abstract] [Full Text] [Related]

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