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Journal Abstract Search

147 related items for PubMed ID: 19596583

  • 1.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 2. Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
    Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N.
    J Med Chem; 2009 Jul 23; 52(14):4111-4. PubMed ID: 19522500
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.
    Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N.
    J Med Chem; 2009 May 28; 52(10):3142-5. PubMed ID: 19388647
    [Abstract] [Full Text] [Related]

  • 4. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool.
    Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.
    J Pharmacol Exp Ther; 2009 Jul 28; 330(1):249-56. PubMed ID: 19359527
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.
    Mizutani T, Ishikawa S, Nagase T, Takahashi H, Fujimura T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N.
    J Med Chem; 2009 Nov 26; 52(22):7289-300. PubMed ID: 19883081
    [Abstract] [Full Text] [Related]

  • 6. Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.
    Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.
    Eur J Pharmacol; 2010 Mar 25; 630(1-3):34-41. PubMed ID: 20045404
    [Abstract] [Full Text] [Related]

  • 7.
    ; . PubMed ID:
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  • 8. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.
    Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ.
    J Med Chem; 2009 Mar 26; 52(6):1723-30. PubMed ID: 19228017
    [Abstract] [Full Text] [Related]

  • 9. Epoxide opening-induced tandem 8-azabicyclo[3.2.1]octane to 6-azabicyclo[3.2.1]octane rearrangement-iminium allylation: synthesis of (+/-)-peduncularine.
    Hodgson DM, Shelton RE, Moss TA, Dekhane M.
    Org Lett; 2010 Jun 18; 12(12):2834-7. PubMed ID: 20469871
    [Abstract] [Full Text] [Related]

  • 10. 1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors.
    Micheli F, Cavanni P, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Checchia A, Davalli S, Di Fabio R, Fazzolari E, Fontana S, Marchioro C, Minick D, Negri M, Oliosi B, Read KD, Sartori I, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L.
    J Med Chem; 2010 Mar 25; 53(6):2534-51. PubMed ID: 20170186
    [Abstract] [Full Text] [Related]

  • 11. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
    Schlienger N, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, Fejzic A, Thygesen MB, Tabatabaei A, Bradley SR, Gardell LR, Piu F, Olsson R.
    J Med Chem; 2009 Nov 26; 52(22):7186-91. PubMed ID: 19856921
    [Abstract] [Full Text] [Related]

  • 12. 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor.
    Micheli F, Cavanni P, Andreotti D, Arban R, Benedetti R, Bertani B, Bettati M, Bettelini L, Bonanomi G, Braggio S, Carletti R, Checchia A, Corsi M, Fazzolari E, Fontana S, Marchioro C, Merlo-Pich E, Negri M, Oliosi B, Ratti E, Read KD, Roscic M, Sartori I, Spada S, Tedesco G, Tarsi L, Terreni S, Visentini F, Zocchi A, Zonzini L, Di Fabio R.
    J Med Chem; 2010 Jul 08; 53(13):4989-5001. PubMed ID: 20527970
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological evaluation of novel 2-[(2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazono]-1,3-thiazolidin-4-ones as a new class of antimicrobial agents.
    Ramachandran R, Rani M, Kabilan S.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2819-23. PubMed ID: 19361987
    [Abstract] [Full Text] [Related]

  • 14. 3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
    Zhang L, Rogers BN, Duplantier AJ, McHardy SF, Efremov I, Berke H, Qian W, Zhang AQ, Maklad N, Candler J, Doran AC, Lazzaro JT, Ganong AH.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5493-6. PubMed ID: 18812259
    [Abstract] [Full Text] [Related]

  • 15. Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout.
    Shimano H.
    Prog Lipid Res; 2012 Jul 15; 51(3):267-71. PubMed ID: 22266797
    [Abstract] [Full Text] [Related]

  • 16. Novel azabicyclo[3.2.2]nonane derivatives and their activities against Plasmodium falciparum K1 and Trypanosoma brucei rhodesiense.
    Berger H, Weis R, Kaiser M, Brun R, Saf R, Seebacher W.
    Bioorg Med Chem; 2008 Jun 15; 16(12):6371-8. PubMed ID: 18502136
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and in vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives.
    Khrizman A, Slack RD, Remsing RC, Little S, Yardley V, Moyna G.
    Arch Pharm (Weinheim); 2007 Nov 15; 340(11):569-76. PubMed ID: 17924365
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and nicotinic acetylcholine receptor binding affinities of 2- and 3-isoxazolyl-8-azabicyclo[3.2.1]octanes.
    Cheng J, Izenwasser S, Zhang C, Zhang S, Wade D, Trudell ML.
    Bioorg Med Chem Lett; 2004 Apr 05; 14(7):1775-8. PubMed ID: 15026069
    [Abstract] [Full Text] [Related]

  • 19. A scalable synthesis of an azabicyclooctanyl derivative, a novel DPP-4 inhibitor.
    Fei Z, Wu Q, Zhang F, Cao Y, Liu C, Shieh WC, Xue S, McKenna J, Prasad K, Prashad M, Baeschlin D, Namoto K.
    J Org Chem; 2008 Nov 21; 73(22):9016-21. PubMed ID: 18850743
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.
    Danilova O, Li B, Szardenings AK, Huber BT, Rosenblum JS.
    Bioorg Med Chem Lett; 2007 Jan 15; 17(2):507-10. PubMed ID: 17055271
    [Abstract] [Full Text] [Related]

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