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319 related items for PubMed ID: 19650874

  • 1. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.
    Rummel A, Häfner K, Mahrhold S, Darashchonak N, Holt M, Jahn R, Beermann S, Karnath T, Bigalke H, Binz T.
    J Neurochem; 2009 Sep; 110(6):1942-54. PubMed ID: 19650874
    [Abstract] [Full Text] [Related]

  • 2. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
    Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
    Biochem J; 2010 Oct 15; 431(2):207-16. PubMed ID: 20704566
    [Abstract] [Full Text] [Related]

  • 3. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity.
    Rummel A.
    Curr Top Microbiol Immunol; 2013 Oct 15; 364():61-90. PubMed ID: 23239349
    [Abstract] [Full Text] [Related]

  • 4. Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F.
    Fu Z, Chen C, Barbieri JT, Kim JJ, Baldwin MR.
    Biochemistry; 2009 Jun 23; 48(24):5631-41. PubMed ID: 19476346
    [Abstract] [Full Text] [Related]

  • 5. Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
    Dong M, Liu H, Tepp WH, Johnson EA, Janz R, Chapman ER.
    Mol Biol Cell; 2008 Dec 23; 19(12):5226-37. PubMed ID: 18815274
    [Abstract] [Full Text] [Related]

  • 6. Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.
    Peng L, Tepp WH, Johnson EA, Dong M.
    PLoS Pathog; 2011 Mar 23; 7(3):e1002008. PubMed ID: 21483489
    [Abstract] [Full Text] [Related]

  • 7. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.
    Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T.
    Biochem J; 2013 Jul 01; 453(1):37-47. PubMed ID: 23621114
    [Abstract] [Full Text] [Related]

  • 8. The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
    Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.
    Mol Microbiol; 2011 Jul 01; 81(1):143-56. PubMed ID: 21542861
    [Abstract] [Full Text] [Related]

  • 9. SV2 is the protein receptor for botulinum neurotoxin A.
    Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER.
    Science; 2006 Apr 28; 312(5773):592-6. PubMed ID: 16543415
    [Abstract] [Full Text] [Related]

  • 10. Novel ganglioside-mediated entry of botulinum neurotoxin serotype D into neurons.
    Kroken AR, Karalewitz AP, Fu Z, Kim JJ, Barbieri JT.
    J Biol Chem; 2011 Jul 29; 286(30):26828-37. PubMed ID: 21632541
    [Abstract] [Full Text] [Related]

  • 11. Botulinum neurotoxin serotype C associates with dual ganglioside receptors to facilitate cell entry.
    Karalewitz AP, Fu Z, Baldwin MR, Kim JJ, Barbieri JT.
    J Biol Chem; 2012 Nov 23; 287(48):40806-16. PubMed ID: 23027864
    [Abstract] [Full Text] [Related]

  • 12. Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.
    Rummel A, Karnath T, Henke T, Bigalke H, Binz T.
    J Biol Chem; 2004 Jul 16; 279(29):30865-70. PubMed ID: 15123599
    [Abstract] [Full Text] [Related]

  • 13. Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.
    Rummel A.
    Curr Top Microbiol Immunol; 2017 Jul 16; 406():1-37. PubMed ID: 27921176
    [Abstract] [Full Text] [Related]

  • 14. Association of botulinum neurotoxin serotypes a and B with synaptic vesicle protein complexes.
    Baldwin MR, Barbieri JT.
    Biochemistry; 2007 Mar 20; 46(11):3200-10. PubMed ID: 17311420
    [Abstract] [Full Text] [Related]

  • 15. Tetanus toxin and botulinum toxin a utilize unique mechanisms to enter neurons of the central nervous system.
    Blum FC, Chen C, Kroken AR, Barbieri JT.
    Infect Immun; 2012 May 20; 80(5):1662-9. PubMed ID: 22392932
    [Abstract] [Full Text] [Related]

  • 16. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.
    Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.
    Biochemistry; 2013 Jun 04; 52(22):3930-8. PubMed ID: 23647335
    [Abstract] [Full Text] [Related]

  • 17. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
    Rummel A, Mahrhold S, Bigalke H, Binz T.
    FEBS J; 2011 Dec 04; 278(23):4506-15. PubMed ID: 21624052
    [Abstract] [Full Text] [Related]

  • 18. Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.
    Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
    Proc Natl Acad Sci U S A; 2007 Jan 02; 104(1):359-64. PubMed ID: 17185412
    [Abstract] [Full Text] [Related]

  • 19. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells.
    Dong M, Richards DA, Goodnough MC, Tepp WH, Johnson EA, Chapman ER.
    J Cell Biol; 2003 Sep 29; 162(7):1293-303. PubMed ID: 14504267
    [Abstract] [Full Text] [Related]

  • 20. Association of botulinum neurotoxins with synaptic vesicle protein complexes.
    Baldwin MR, Barbieri JT.
    Toxicon; 2009 Oct 29; 54(5):570-4. PubMed ID: 19362106
    [Abstract] [Full Text] [Related]

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