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Journal Abstract Search

183 related items for PubMed ID: 19660987

  • 1. Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors.
    Lauria A, Ippolito M, Almerico AM.
    Comput Biol Chem; 2009 Oct; 33(5):386-90. PubMed ID: 19660987
    [Abstract] [Full Text] [Related]

  • 2.
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  • 3. Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
    Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F.
    J Med Chem; 2008 Feb 14; 51(3):373-5. PubMed ID: 18197612
    [Abstract] [Full Text] [Related]

  • 4. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
    He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G.
    J Med Chem; 2006 Jan 12; 49(1):381-90. PubMed ID: 16392823
    [Abstract] [Full Text] [Related]

  • 5. Inside the Hsp90 inhibitors binding mode through induced fit docking.
    Lauria A, Ippolito M, Almerico AM.
    J Mol Graph Model; 2009 Feb 12; 27(6):712-22. PubMed ID: 19084447
    [Abstract] [Full Text] [Related]

  • 6. Structure-based discovery of a new class of Hsp90 inhibitors.
    Barril X, Brough P, Drysdale M, Hubbard RE, Massey A, Surgenor A, Wright L.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5187-91. PubMed ID: 16202589
    [Abstract] [Full Text] [Related]

  • 7. A novel class of Hsp90 inhibitors isolated by structure-based virtual screening.
    Park H, Kim YJ, Hahn JS.
    Bioorg Med Chem Lett; 2007 Nov 15; 17(22):6345-9. PubMed ID: 17869098
    [Abstract] [Full Text] [Related]

  • 8. Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
    Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE.
    Chem Biol; 2004 Jun 15; 11(6):775-85. PubMed ID: 15217611
    [Abstract] [Full Text] [Related]

  • 9. Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer.
    Moser C, Lang SA, Stoeltzing O.
    Anticancer Res; 2009 Jun 15; 29(6):2031-42. PubMed ID: 19528462
    [Abstract] [Full Text] [Related]

  • 10. Purine-scaffold Hsp90 inhibitors.
    Chiosis G, Tao H.
    IDrugs; 2006 Nov 15; 9(11):778-82. PubMed ID: 17096299
    [Abstract] [Full Text] [Related]

  • 11. Molecular modelling and docking studies on heat shock protein 90 (Hsp90) inhibitors.
    Saxena AK, Saxena S, Chaudhaery SS.
    SAR QSAR Environ Res; 2010 Jan 01; 21(1):1-20. PubMed ID: 20373211
    [Abstract] [Full Text] [Related]

  • 12. Discovery of a novel Hsp90 inhibitor by fragment linking.
    Barker JJ, Barker O, Courtney SM, Gardiner M, Hesterkamp T, Ichihara O, Mather O, Montalbetti CA, Müller A, Varasi M, Whittaker M, Yarnold CJ.
    ChemMedChem; 2010 Oct 04; 5(10):1697-700. PubMed ID: 20665758
    [No Abstract] [Full Text] [Related]

  • 13. Inhibition of cancer invasion and metastasis by targeting the molecular chaperone heat-shock protein 90.
    Koga F, Kihara K, Neckers L.
    Anticancer Res; 2009 Mar 04; 29(3):797-807. PubMed ID: 19414312
    [Abstract] [Full Text] [Related]

  • 14. The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
    Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P.
    Bioorg Med Chem Lett; 2005 Jul 15; 15(14):3338-43. PubMed ID: 15955698
    [Abstract] [Full Text] [Related]

  • 15. Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin.
    Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG.
    J Med Chem; 2009 Apr 23; 52(8):2177-80. PubMed ID: 19331414
    [Abstract] [Full Text] [Related]

  • 16. 3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.
    Brough PA, Barril X, Beswick M, Dymock BW, Drysdale MJ, Wright L, Grant K, Massey A, Surgenor A, Workman P.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5197-201. PubMed ID: 16213716
    [Abstract] [Full Text] [Related]

  • 17. Fragment-based identification of Hsp90 inhibitors.
    Barker JJ, Barker O, Boggio R, Chauhan V, Cheng RK, Corden V, Courtney SM, Edwards N, Falque VM, Fusar F, Gardiner M, Hamelin EM, Hesterkamp T, Ichihara O, Jones RS, Mather O, Mercurio C, Minucci S, Montalbetti CA, Müller A, Patel D, Phillips BG, Varasi M, Whittaker M, Winkler D, Yarnold CJ.
    ChemMedChem; 2009 Jun 01; 4(6):963-6. PubMed ID: 19301319
    [Abstract] [Full Text] [Related]

  • 18. 7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.
    Zhang L, Fan J, Vu K, Hong K, Le Brazidec JY, Shi J, Biamonte M, Busch DJ, Lough RE, Grecko R, Ran Y, Sensintaffar JL, Kamal A, Lundgren K, Burrows FJ, Mansfield R, Timony GA, Ulm EH, Kasibhatla SR, Boehm MF.
    J Med Chem; 2006 Aug 24; 49(17):5352-62. PubMed ID: 16913725
    [Abstract] [Full Text] [Related]

  • 19. Identification of new Hsp90 inhibitors by structure-based virtual screening.
    Hong TJ, Park H, Kim YJ, Jeong JH, Hahn JS.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4839-42. PubMed ID: 19560353
    [Abstract] [Full Text] [Related]

  • 20. 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone.
    Cikotiene I, Kazlauskas E, Matuliene J, Michailoviene V, Torresan J, Jachno J, Matulis D.
    Bioorg Med Chem Lett; 2009 Feb 15; 19(4):1089-92. PubMed ID: 19168355
    [Abstract] [Full Text] [Related]

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