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Journal Abstract Search

312 related items for PubMed ID: 19666228

  • 1. Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
    Hocková D, Holý A, Masojídková M, Keough DT, de Jersey J, Guddat LW.
    Bioorg Med Chem; 2009 Sep 01; 17(17):6218-32. PubMed ID: 19666228
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.
    Krečmerová M, Dračínský M, Hocková D, Holý A, Keough DT, Guddat LW.
    Bioorg Med Chem; 2012 Feb 01; 20(3):1222-30. PubMed ID: 22249123
    [Abstract] [Full Text] [Related]

  • 3. Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
    Hocková D, Keough DT, Janeba Z, Wang TH, de Jersey J, Guddat LW.
    J Med Chem; 2012 Jul 12; 55(13):6209-23. PubMed ID: 22725979
    [Abstract] [Full Text] [Related]

  • 4. Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
    Česnek M, Hocková D, Holý A, Dračínský M, Baszczyňski O, Jersey Jd, Keough DT, Guddat LW.
    Bioorg Med Chem; 2012 Jan 15; 20(2):1076-89. PubMed ID: 22178188
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
    Keough DT, Hocková D, Holý A, Naesens LM, Skinner-Adams TS, Jersey Jd, Guddat LW.
    J Med Chem; 2009 Jul 23; 52(14):4391-9. PubMed ID: 19527031
    [Abstract] [Full Text] [Related]

  • 6. The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
    Baszczyňski O, Hocková D, Janeba Z, Holý A, Jansa P, Dračínský M, Keough DT, Guddat LW.
    Eur J Med Chem; 2013 Sep 23; 67():81-9. PubMed ID: 23850568
    [Abstract] [Full Text] [Related]

  • 7. Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
    Klejch T, Keough DT, Chavchich M, Travis J, Skácel J, Pohl R, Janeba Z, Edstein MD, Avery VM, Guddat LW, Hocková D.
    Eur J Med Chem; 2019 Dec 01; 183():111667. PubMed ID: 31536893
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
    Kaiser MM, Hocková D, Wang TH, Dračínský M, Poštová-Slavětínská L, Procházková E, Edstein MD, Chavchich M, Keough DT, Guddat LW, Janeba Z.
    ChemMedChem; 2015 Oct 01; 10(10):1707-23. PubMed ID: 26368337
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  • 11. Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.
    Špaček P, Keough DT, Chavchich M, Dračínský M, Janeba Z, Naesens L, Edstein MD, Guddat LW, Hocková D.
    J Med Chem; 2017 Sep 14; 60(17):7539-7554. PubMed ID: 28813147
    [Abstract] [Full Text] [Related]

  • 12. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
    Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW.
    J Med Chem; 2013 Mar 28; 56(6):2513-26. PubMed ID: 23448281
    [Abstract] [Full Text] [Related]

  • 13. N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
    Vaňková K, Keough DT, Hocková D, Guddat LW, Janeba Z.
    ChemMedChem; 2023 Aug 01; 18(15):e202300211. PubMed ID: 37264975
    [Abstract] [Full Text] [Related]

  • 14. Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents.
    Keough DT, Hocková D, Janeba Z, Wang TH, Naesens L, Edstein MD, Chavchich M, Guddat LW.
    J Med Chem; 2015 Jan 22; 58(2):827-46. PubMed ID: 25494538
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  • 16. Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.
    Keough DT, Skinner-Adams T, Jones MK, Ng AL, Brereton IM, Guddat LW, de Jersey J.
    J Med Chem; 2006 Dec 14; 49(25):7479-86. PubMed ID: 17149876
    [Abstract] [Full Text] [Related]

  • 17. Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
    Hazleton KZ, Ho MC, Cassera MB, Clinch K, Crump DR, Rosario I, Merino EF, Almo SC, Tyler PC, Schramm VL.
    Chem Biol; 2012 Jun 22; 19(6):721-30. PubMed ID: 22726686
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  • 18. Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
    Frydrych J, Keough DT, Chavchich M, Travis J, Dračínský M, Edstein MD, Guddat LW, Hocková D, Janeba Z.
    Eur J Med Chem; 2021 Jul 05; 219():113416. PubMed ID: 33887682
    [Abstract] [Full Text] [Related]

  • 19. Plasmodium falciparum: new molecular targets with potential for antimalarial drug development.
    Gardiner DL, Skinner-Adams TS, Brown CL, Andrews KT, Stack CM, McCarthy JS, Dalton JP, Trenholme KR.
    Expert Rev Anti Infect Ther; 2009 Nov 05; 7(9):1087-98. PubMed ID: 19883329
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