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245 related items for PubMed ID: 19666988

  • 1. Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
    Metry KJ, Neale JR, Bendaly J, Smith NB, Pierce WM, Hein DW.
    Drug Metab Dispos; 2009 Nov; 37(11):2123-6. PubMed ID: 19666988
    [Abstract] [Full Text] [Related]

  • 2. 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
    Bendaly J, Zhao S, Neale JR, Metry KJ, Doll MA, States JC, Pierce WM, Hein DW.
    Cancer Epidemiol Biomarkers Prev; 2007 Jul; 16(7):1503-9. PubMed ID: 17627018
    [Abstract] [Full Text] [Related]

  • 3. DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.
    Fretland AJ, Devanaboyina US, Nangju NA, Leff MA, Xiao GH, Webb SJ, Doll MA, Hein DW.
    J Biochem Mol Toxicol; 2001 Jul; 15(1):26-33. PubMed ID: 11170312
    [Abstract] [Full Text] [Related]

  • 4. Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
    Fretland AJ, Devanaboyina US, Doll MA, Zhao S, Xiao GH, Hein DW.
    Toxicol Sci; 2003 Aug; 74(2):253-9. PubMed ID: 12773763
    [Abstract] [Full Text] [Related]

  • 5. 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine-induced DNA adducts and genotoxicity in chinese hamster ovary (CHO) cells expressing human CYP1A2 and rapid or slow acetylator N-acetyltransferase 2.
    Metry KJ, Zhao S, Neale JR, Doll MA, States JC, McGregor WG, Pierce WM, Hein DW.
    Mol Carcinog; 2007 Jul; 46(7):553-63. PubMed ID: 17295238
    [Abstract] [Full Text] [Related]

  • 6. Oral administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) yields PhIP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.
    Fretland AJ, Devanaboyina US, Feng Y, Leff MA, Xiao GH, Webb SJ, Hein DW.
    Toxicol Sci; 2001 Feb; 59(2):226-30. PubMed ID: 11158715
    [Abstract] [Full Text] [Related]

  • 7. DNA adduct levels and intestinal lesions in congenic rapid and slow acetylator syrian hamsters admi food mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).
    Steffensen IL, Fretland AJ, Paulsen JE, Feng Y, Eide TJ, Devanaboyina US, Hein DW, Alexander J.
    Pharmacol Toxicol; 2000 Jun; 86(6):257-63. PubMed ID: 10895988
    [Abstract] [Full Text] [Related]

  • 8. Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
    Metry KJ, Neale JR, Doll MA, Howarth AL, States JC, McGregor WG, Pierce WM, Hein DW.
    Mutat Res; 2010 Feb 03; 684(1-2):66-73. PubMed ID: 20004212
    [Abstract] [Full Text] [Related]

  • 9. Analysis and quantification of DNA adducts of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in liver of rats by liquid chromatography/electrospray tandem mass spectrometry.
    Paehler A, Richoz J, Soglia J, Vouros P, Turesky RJ.
    Chem Res Toxicol; 2002 Apr 03; 15(4):551-61. PubMed ID: 11952342
    [Abstract] [Full Text] [Related]

  • 10. DNA adduct levels in rapid and slow acetylator inbred rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    Fretland AJ, Feng Y, Hein DW.
    Proc West Pharmacol Soc; 1997 Apr 03; 40():9-12. PubMed ID: 9436199
    [No Abstract] [Full Text] [Related]

  • 11. Novel LC-ESI/MS/MS(n) method for the characterization and quantification of 2'-deoxyguanosine adducts of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by 2-D linear quadrupole ion trap mass spectrometry.
    Goodenough AK, Schut HA, Turesky RJ.
    Chem Res Toxicol; 2007 Feb 03; 20(2):263-76. PubMed ID: 17305409
    [Abstract] [Full Text] [Related]

  • 12. Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts.
    Bendaly J, Metry KJ, Doll MA, Jiang G, States JC, Smith NB, Neale JR, Holloman JL, Pierce WM, Hein DW.
    Xenobiotica; 2009 May 03; 39(5):399-406. PubMed ID: 19301197
    [Abstract] [Full Text] [Related]

  • 13. Association between acetylator genotype and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) DNA adduct formation in colon and prostate of inbred Fischer 344 and Wistar Kyoto rats.
    Purewal M, Fretland AJ, Schut HA, Hein DW, Wargovich MJ.
    Cancer Lett; 2000 Feb 28; 149(1-2):53-60. PubMed ID: 10737708
    [Abstract] [Full Text] [Related]

  • 14. Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl.
    Feng Y, Fretland AJ, Rustan TD, Jiang W, Becker WK, Hein DW.
    Toxicol Appl Pharmacol; 1997 Nov 28; 147(1):56-62. PubMed ID: 9356307
    [Abstract] [Full Text] [Related]

  • 15. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon.
    Turesky RJ, Lang NP, Butler MA, Teitel CH, Kadlubar FF.
    Carcinogenesis; 1991 Oct 28; 12(10):1839-45. PubMed ID: 1934265
    [Abstract] [Full Text] [Related]

  • 16. Excretion of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, PhIP-dG, PhIP-DNA and DiMeIQx-DNA from the rat.
    Frandsen H.
    Carcinogenesis; 1997 Aug 28; 18(8):1555-60. PubMed ID: 9276630
    [Abstract] [Full Text] [Related]

  • 17. Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.
    Hein DW, Fretland AJ, Doll MA.
    Int J Cancer; 2006 Sep 01; 119(5):1208-11. PubMed ID: 16570281
    [Abstract] [Full Text] [Related]

  • 18. Biomonitoring DNA Adducts of Cooked Meat Carcinogens in Human Prostate by Nano Liquid Chromatography-High Resolution Tandem Mass Spectrometry: Identification of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA Adduct.
    Xiao S, Guo J, Yun BH, Villalta PW, Krishna S, Tejpaul R, Murugan P, Weight CJ, Turesky RJ.
    Anal Chem; 2016 Dec 20; 88(24):12508-12515. PubMed ID: 28139123
    [Abstract] [Full Text] [Related]

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  • 20. 32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.
    Snyderwine EG, Davis CD, Nouso K, Roller PP, Schut HA.
    Carcinogenesis; 1993 Jul 20; 14(7):1389-95. PubMed ID: 8330355
    [Abstract] [Full Text] [Related]

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