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192 related items for PubMed ID: 19695655

  • 1. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth.
    Gustchina E, Louis JM, Frisch C, Ylera F, Lechner A, Bewley CA, Clore GM.
    Virology; 2009 Oct 10; 393(1):112-9. PubMed ID: 19695655
    [Abstract] [Full Text] [Related]

  • 2. Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.
    Gustchina E, Li M, Louis JM, Anderson DE, Lloyd J, Frisch C, Bewley CA, Gustchina A, Wlodawer A, Clore GM.
    PLoS Pathog; 2010 Nov 11; 6(11):e1001182. PubMed ID: 21085615
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  • 3. Characterization and HIV-1 fusion inhibitory properties of monoclonal Fabs obtained from a human non-immune phage library selected against diverse epitopes of the ectodomain of HIV-1 gp41.
    Louis JM, Bewley CA, Gustchina E, Aniana A, Clore GM.
    J Mol Biol; 2005 Nov 11; 353(5):945-51. PubMed ID: 16216270
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  • 4. Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations.
    Louis JM, Aniana A, Lohith K, Sayer JM, Roche J, Bewley CA, Clore GM.
    PLoS One; 2014 Nov 11; 9(8):e104683. PubMed ID: 25105806
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  • 5. Sequestering of the prehairpin intermediate of gp41 by peptide N36Mut(e,g) potentiates the human immunodeficiency virus type 1 neutralizing activity of monoclonal antibodies directed against the N-terminal helical repeat of gp41.
    Gustchina E, Bewley CA, Clore GM.
    J Virol; 2008 Oct 11; 82(20):10032-41. PubMed ID: 18667502
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  • 8. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.
    Nelson JD, Kinkead H, Brunel FM, Leaman D, Jensen R, Louis JM, Maruyama T, Bewley CA, Bowdish K, Clore GM, Dawson PE, Frederickson S, Mage RG, Richman DD, Burton DR, Zwick MB.
    Virology; 2008 Jul 20; 377(1):170-83. PubMed ID: 18499210
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  • 9. Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41.
    Montgomery DL, Wang YJ, Hrin R, Luftig M, Su B, Miller MD, Wang F, Haytko P, Huang L, Vitelli S, Condra J, Liu X, Hampton R, Carfi A, Pessi A, Bianchi E, Joyce J, Lloyd C, Geleziunas R, Bramhill D, King VM, Finnefrock AC, Strohl W, An Z.
    MAbs; 2009 Jul 20; 1(5):462-74. PubMed ID: 20065653
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  • 10. An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10.
    Nelson JD, Brunel FM, Jensen R, Crooks ET, Cardoso RM, Wang M, Hessell A, Wilson IA, Binley JM, Dawson PE, Burton DR, Zwick MB.
    J Virol; 2007 Apr 20; 81(8):4033-43. PubMed ID: 17287272
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  • 11. Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies.
    Choudhry V, Zhang MY, Sidorov IA, Louis JM, Harris I, Dimitrov AS, Bouma P, Cham F, Choudhary A, Rybak SM, Fouts T, Montefiori DC, Broder CC, Quinnan GV, Dimitrov DS.
    Virology; 2007 Jun 20; 363(1):79-90. PubMed ID: 17306322
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  • 12. Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding.
    Binley JM, Ditzel HJ, Barbas CF, Sullivan N, Sodroski J, Parren PW, Burton DR.
    AIDS Res Hum Retroviruses; 1996 Jul 01; 12(10):911-24. PubMed ID: 8798976
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  • 14. Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.
    Sabin C, Corti D, Buzon V, Seaman MS, Lutje Hulsik D, Hinz A, Vanzetta F, Agatic G, Silacci C, Mainetti L, Scarlatti G, Sallusto F, Weiss R, Lanzavecchia A, Weissenhorn W.
    PLoS Pathog; 2010 Nov 18; 6(11):e1001195. PubMed ID: 21124990
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  • 16. Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody.
    Conley AJ, Kessler JA, Boots LJ, Tung JS, Arnold BA, Keller PM, Shaw AR, Emini EA.
    Proc Natl Acad Sci U S A; 1994 Apr 12; 91(8):3348-52. PubMed ID: 7512731
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  • 17. Synthetic Fab fragments that bind the HIV-1 gp41 heptad repeat regions.
    Liu Y, Regula LK, Stewart A, Lai JR.
    Biochem Biophys Res Commun; 2011 Oct 07; 413(4):611-5. PubMed ID: 21925149
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  • 18. Examination of the contributions of size and avidity to the neutralization mechanisms of the anti-HIV antibodies b12 and 4E10.
    Klein JS, Gnanapragasam PN, Galimidi RP, Foglesong CP, West AP, Bjorkman PJ.
    Proc Natl Acad Sci U S A; 2009 May 05; 106(18):7385-90. PubMed ID: 19372381
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  • 19. [Identification of human monoclonal HIV-1-neutralizing antibodies from phage antibody library by cell-based screening].
    Zhang N, Man L, Sun JP, Meng JZ, He YX.
    Bing Du Xue Bao; 2013 Sep 05; 29(5):471-9. PubMed ID: 24386834
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  • 20. Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficiency virus type 1 gp41.
    Gorny MK, Zolla-Pazner S.
    J Virol; 2000 Jul 05; 74(13):6186-92. PubMed ID: 10846104
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