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304 related items for PubMed ID: 19696166

  • 1. Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1alpha.
    Lee YM, Lim JH, Chun YS, Moon HE, Lee MK, Huang LE, Park JW.
    Carcinogenesis; 2009 Oct; 30(10):1768-75. PubMed ID: 19696166
    [Abstract] [Full Text] [Related]

  • 2. Effect of MDM2 and vascular endothelial growth factor inhibition on tumor angiogenesis and metastasis in neuroblastoma.
    Patterson DM, Gao D, Trahan DN, Johnson BA, Ludwig A, Barbieri E, Chen Z, Diaz-Miron J, Vassilev L, Shohet JM, Kim ES.
    Angiogenesis; 2011 Sep; 14(3):255-66. PubMed ID: 21484514
    [Abstract] [Full Text] [Related]

  • 3. Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.
    LaRusch GA, Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD.
    Cancer Res; 2007 Jan 15; 67(2):450-4. PubMed ID: 17234751
    [Abstract] [Full Text] [Related]

  • 4. Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1alpha.
    Shin DH, Li SH, Yang SW, Lee BL, Lee MK, Park JW.
    FEBS J; 2009 Jul 15; 276(13):3470-80. PubMed ID: 19456861
    [Abstract] [Full Text] [Related]

  • 5. A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.
    Li SH, Shin DH, Chun YS, Lee MK, Kim MS, Park JW.
    Mol Cancer Ther; 2008 Dec 15; 7(12):3729-38. PubMed ID: 19074848
    [Abstract] [Full Text] [Related]

  • 6. Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.
    Shin DH, Chun YS, Lee DS, Huang LE, Park JW.
    Blood; 2008 Mar 15; 111(6):3131-6. PubMed ID: 18174379
    [Abstract] [Full Text] [Related]

  • 7. HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.
    Lau LM, Nugent JK, Zhao X, Irwin MS.
    Oncogene; 2008 Feb 07; 27(7):997-1003. PubMed ID: 17700533
    [Abstract] [Full Text] [Related]

  • 8. CITED2 mediates the paradoxical responses of HIF-1alpha to proteasome inhibition.
    Shin DH, Li SH, Chun YS, Huang LE, Kim MS, Park JW.
    Oncogene; 2008 Mar 20; 27(13):1939-44. PubMed ID: 17906695
    [Abstract] [Full Text] [Related]

  • 9. The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha.
    Dayan F, Roux D, Brahimi-Horn MC, Pouyssegur J, Mazure NM.
    Cancer Res; 2006 Apr 01; 66(7):3688-98. PubMed ID: 16585195
    [Abstract] [Full Text] [Related]

  • 10. MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).
    Webb JD, Murányi A, Pugh CW, Ratcliffe PJ, Coleman ML.
    Biochem J; 2009 May 13; 420(2):327-33. PubMed ID: 19245366
    [Abstract] [Full Text] [Related]

  • 11. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.
    Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ.
    J Biol Chem; 2004 Apr 02; 279(14):14391-7. PubMed ID: 14734545
    [Abstract] [Full Text] [Related]

  • 12. Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
    Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H.
    Mol Pharmacol; 2008 Jul 02; 74(1):236-45. PubMed ID: 18426857
    [Abstract] [Full Text] [Related]

  • 13. Ferritin heavy chain controls the HIF-driven hypoxic response by activating the asparaginyl hydroxylase FIH.
    Jin P, Kang J, Lee MK, Park JW.
    Biochem Biophys Res Commun; 2018 May 15; 499(3):475-481. PubMed ID: 29580991
    [Abstract] [Full Text] [Related]

  • 14. The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.
    Welsh SJ, Bellamy WT, Briehl MM, Powis G.
    Cancer Res; 2002 Sep 01; 62(17):5089-95. PubMed ID: 12208766
    [Abstract] [Full Text] [Related]

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  • 16. Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.
    Patton JT, Mayo LD, Singhi AD, Gudkov AV, Stark GR, Jackson MW.
    Cancer Res; 2006 Mar 15; 66(6):3169-76. PubMed ID: 16540668
    [Abstract] [Full Text] [Related]

  • 17. [Growth Regulation of Factor Inhibiting Hypoxia-Inducible Factor in Renal Carcinoma Cells].
    Deng S, Yang B, Ren ZJ, Dong Q.
    Sichuan Da Xue Xue Bao Yi Xue Ban; 2018 Jan 15; 49(1):29-33. PubMed ID: 29737085
    [Abstract] [Full Text] [Related]

  • 18. CITED2 controls the hypoxic signaling by snatching p300 from the two distinct activation domains of HIF-1α.
    Yoon H, Lim JH, Cho CH, Huang LE, Park JW.
    Biochim Biophys Acta; 2011 Dec 15; 1813(12):2008-16. PubMed ID: 21925214
    [Abstract] [Full Text] [Related]

  • 19. Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression.
    Bárdos JI, Chau NM, Ashcroft M.
    Mol Cell Biol; 2004 Apr 15; 24(7):2905-14. PubMed ID: 15024078
    [Abstract] [Full Text] [Related]

  • 20. p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1).
    Schmid T, Zhou J, Köhl R, Brüne B.
    Biochem J; 2004 May 15; 380(Pt 1):289-95. PubMed ID: 14992692
    [Abstract] [Full Text] [Related]

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