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Journal Abstract Search

212 related items for PubMed ID: 19722626

  • 1. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.
    Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC.
    J Am Chem Soc; 2009 Aug 05; 131(30):10497-506. PubMed ID: 19722626
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  • 2. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase.
    Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL.
    J Am Chem Soc; 2011 Mar 23; 133(11):4092-100. PubMed ID: 21355555
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  • 3. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.
    Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL.
    J Med Chem; 2010 Jan 14; 53(1):230-40. PubMed ID: 19924997
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  • 9. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.
    Garfunkle J, Ezzili C, Rayl TJ, Hochstatter DG, Hwang I, Boger DL.
    J Med Chem; 2008 Aug 14; 51(15):4392-403. PubMed ID: 18630870
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  • 13. Nonempirical energetic analysis of reactivity and covalent inhibition of fatty acid amide hydrolase.
    Chudyk EI, Dyguda-Kazimierowicz E, Langner KM, Sokalski WA, Lodola A, Mor M, Sirirak J, Mulholland AJ.
    J Phys Chem B; 2013 Jun 06; 117(22):6656-66. PubMed ID: 23654226
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  • 16. Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH).
    Bowman AL, Makriyannis A.
    J Chem Inf Model; 2011 Dec 27; 51(12):3247-53. PubMed ID: 22098169
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  • 17. Structure-guided inhibitor design for human FAAH by interspecies active site conversion.
    Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC.
    Proc Natl Acad Sci U S A; 2008 Sep 02; 105(35):12820-4. PubMed ID: 18753625
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  • 19. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology.
    Lamani M, Malamas MS, Farah SI, Shukla VG, Almeida MF, Weerts CM, Anderson J, Wood JT, Farizatto KLG, Bahr BA, Makriyannis A.
    Bioorg Med Chem; 2019 Dec 01; 27(23):115096. PubMed ID: 31629610
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  • 20. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
    Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M.
    J Med Chem; 2013 Mar 28; 56(6):2500-12. PubMed ID: 23425199
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