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Journal Abstract Search

324 related items for PubMed ID: 19725579

  • 1. Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
    Gardelli C, Attenni B, Donghi M, Meppen M, Pacini B, Harper S, Di Marco A, Fiore F, Giuliano C, Pucci V, Laufer R, Gennari N, Marcucci I, Leone JF, Olsen DB, MacCoss M, Rowley M, Narjes F.
    J Med Chem; 2009 Sep 10; 52(17):5394-407. PubMed ID: 19725579
    [Abstract] [Full Text] [Related]

  • 2. Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.
    Meppen M, Pacini B, Bazzo R, Koch U, Leone JF, Koeplinger KA, Rowley M, Altamura S, Di Marco A, Fiore F, Giuliano C, Gonzalez-Paz O, Laufer R, Pucci V, Narjes F, Gardelli C.
    Eur J Med Chem; 2009 Sep 10; 44(9):3765-70. PubMed ID: 19493593
    [Abstract] [Full Text] [Related]

  • 3. Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
    McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.
    J Med Chem; 2010 Jul 08; 53(13):4949-57. PubMed ID: 20527890
    [Abstract] [Full Text] [Related]

  • 4. Antiviral efficacy upon administration of a HepDirect prodrug of 2'-C-methylcytidine to hepatitis C virus-infected chimpanzees.
    Carroll SS, Koeplinger K, Vavrek M, Zhang NR, Handt L, MacCoss M, Olsen DB, Reddy KR, Sun Z, van Poelje PD, Fujitaki JM, Boyer SH, Linemeyer DL, Hecker SJ, Erion MD.
    Antimicrob Agents Chemother; 2011 Aug 08; 55(8):3854-60. PubMed ID: 21628542
    [Abstract] [Full Text] [Related]

  • 5. Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.
    Hecker SJ, Reddy KR, van Poelje PD, Sun Z, Huang W, Varkhedkar V, Reddy MV, Fujitaki JM, Olsen DB, Koeplinger KA, Boyer SH, Linemeyer DL, MacCoss M, Erion MD.
    J Med Chem; 2007 Aug 09; 50(16):3891-6. PubMed ID: 17636948
    [Abstract] [Full Text] [Related]

  • 6. Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
    Maiti M, Gao LJ, Huang C, Ptak RG, Murray MG, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2016 Sep 21; 14(37):8743-8757. PubMed ID: 27714209
    [Abstract] [Full Text] [Related]

  • 7. The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
    McGuigan C, Perrone P, Madela K, Neyts J.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4316-20. PubMed ID: 19523820
    [Abstract] [Full Text] [Related]

  • 8. The application of the phosphoramidate ProTide approach confers micromolar potency against hepatitis C virus on inactive agent 4'-azidoinosine: kinase bypass on a dual base/sugar modified nucleoside.
    McGuigan C, Daverio F, Nájera I, Martin JA, Klumpp K, Smith DB.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3122-4. PubMed ID: 19398331
    [Abstract] [Full Text] [Related]

  • 9. QSAR models for phosphoramidate prodrugs of 2'-methylcytidine as inhibitors of hepatitis C virus based on PSO boosting.
    Cheng Z, Zhang Y, Zhou C.
    Chem Biol Drug Des; 2011 Dec 01; 78(6):948-59. PubMed ID: 21895985
    [Abstract] [Full Text] [Related]

  • 10. Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite.
    Golitsina NL, Danehy FT, Fellows R, Cretton-Scott E, Standring DN.
    Antiviral Res; 2010 Mar 01; 85(3):470-81. PubMed ID: 19883694
    [Abstract] [Full Text] [Related]

  • 11. Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
    McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.
    Bioorg Med Chem Lett; 2011 Oct 01; 21(19):6007-12. PubMed ID: 21856153
    [Abstract] [Full Text] [Related]

  • 12. Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
    Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.
    Antivir Chem Chemother; 2009 Oct 19; 20(2):99-106. PubMed ID: 19843980
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase.
    Donghi M, Attenni B, Gardelli C, Marco AD, Fiore F, Giuliano C, Laufer R, Leone JF, Pucci V, Rowley M, Narjes F.
    Bioorg Med Chem Lett; 2009 Mar 01; 19(5):1392-5. PubMed ID: 19181520
    [Abstract] [Full Text] [Related]

  • 14. First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.
    Perrone P, Daverio F, Valente R, Rajyaguru S, Martin JA, Lévêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C.
    J Med Chem; 2007 Nov 01; 50(22):5463-70. PubMed ID: 17914786
    [Abstract] [Full Text] [Related]

  • 15. Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
    Perrone P, Luoni GM, Kelleher MR, Daverio F, Angell A, Mulready S, Congiatu C, Rajyaguru S, Martin JA, Levêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C.
    J Med Chem; 2007 Apr 19; 50(8):1840-9. PubMed ID: 17367121
    [Abstract] [Full Text] [Related]

  • 16. Successful kinase bypass with new acyclovir phosphoramidate prodrugs.
    McGuigan C, Derudas M, Bugert JJ, Andrei G, Snoeck R, Balzarini J.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4364-7. PubMed ID: 18614365
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
    Kirschberg TA, Mish MR, Zhang L, Squires NH, Wang KY, Cho A, Feng JY, Fenaux M, Babusis D, Park Y, Ray AS, Kim CU.
    Bioorg Med Chem Lett; 2015 Mar 01; 25(5):1040-3. PubMed ID: 25650256
    [Abstract] [Full Text] [Related]

  • 18. Phosphoramidate prodrugs deliver with potency against hepatitis C virus.
    Mehellou Y.
    ChemMedChem; 2010 Nov 08; 5(11):1841-2. PubMed ID: 20865770
    [No Abstract] [Full Text] [Related]

  • 19. Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication.
    Maiti M, Maiti M, Rozenski J, De Jonghe S, Herdewijn P.
    Org Biomol Chem; 2015 May 14; 13(18):5158-74. PubMed ID: 25849139
    [Abstract] [Full Text] [Related]

  • 20. Discovery of β-d-2'-deoxy-2'-dichlorouridine nucleotide prodrugs as potent inhibitors of hepatitis C virus replication.
    Pinho P, Kalayanov G, Westerlind H, Rosenquist Å, Wähling H, Sund C, Almeida M, Ayesa S, Tejbrant J, Targett-Adams P, Eneroth A, Lindqvist A.
    Bioorg Med Chem Lett; 2017 Aug 01; 27(15):3468-3471. PubMed ID: 28622881
    [Abstract] [Full Text] [Related]

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