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PUBMED FOR HANDHELDS

Journal Abstract Search

247 related items for PubMed ID: 19746978

  • 21.
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  • 22. Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
    Pfefferkorn JA, Guzman-Perez A, Litchfield J, Aiello R, Treadway JL, Pettersen J, Minich ML, Filipski KJ, Jones CS, Tu M, Aspnes G, Risley H, Bian J, Stevens BD, Bourassa P, D'Aquila T, Baker L, Barucci N, Robertson AS, Bourbonais F, Derksen DR, Macdougall M, Cabrera O, Chen J, Lapworth AL, Landro JA, Zavadoski WJ, Atkinson K, Haddish-Berhane N, Tan B, Yao L, Kosa RE, Varma MV, Feng B, Duignan DB, El-Kattan A, Murdande S, Liu S, Ammirati M, Knafels J, Dasilva-Jardine P, Sweet L, Liras S, Rolph TP.
    J Med Chem; 2012 Feb 09; 55(3):1318-33. PubMed ID: 22196621
    [Abstract] [Full Text] [Related]

  • 23. Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus.
    Kaushik A, Kaushik M.
    Curr Diabetes Rev; 2019 Feb 09; 15(3):205-212. PubMed ID: 30039763
    [Abstract] [Full Text] [Related]

  • 24. Allosteric activators of glucokinase: potential role in diabetes therapy.
    Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE, Marcus L, Qi L, Spence CL, Tengi J, Magnuson MA, Chu CA, Dvorozniak MT, Matschinsky FM, Grippo JF.
    Science; 2003 Jul 18; 301(5631):370-3. PubMed ID: 12869762
    [Abstract] [Full Text] [Related]

  • 25. Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
    Xu J, Lin S, Myers RW, Trujillo ME, Pachanski MJ, Malkani S, Chen HS, Chen Z, Campbell B, Eiermann GJ, Elowe N, Farrer BT, Feng W, Fu Q, Kats-Kagan R, Kavana M, McMasters DR, Mitra K, Tong X, Xu L, Zhang F, Zhang R, Addona GH, Berger JP, Zhang B, Parmee ER.
    Bioorg Med Chem Lett; 2017 May 01; 27(9):2063-2068. PubMed ID: 28284809
    [Abstract] [Full Text] [Related]

  • 26. Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus.
    Fujieda H, Kogami M, Sakairi M, Kato N, Makino M, Takahashi N, Miyazawa T, Harada S, Yamashita T.
    Eur J Med Chem; 2018 Aug 05; 156():269-294. PubMed ID: 30006171
    [Abstract] [Full Text] [Related]

  • 27. Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus.
    Park K.
    Arch Pharm Res; 2012 Dec 05; 35(12):2029-33. PubMed ID: 23263798
    [Abstract] [Full Text] [Related]

  • 28. Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
    Xu J, Lin S, Myers RW, Addona G, Berger JP, Campbell B, Chen HS, Chen Z, Eiermann GJ, Elowe NH, Farrer BT, Feng W, Fu Q, Kats-Kagan R, Kavana M, Malkani S, McMasters DR, Mitra K, Pachanski MJ, Tong X, Trujillo ME, Xu L, Zhang B, Zhang F, Zhang R, Parmee ER.
    Bioorg Med Chem Lett; 2017 May 01; 27(9):2069-2073. PubMed ID: 28284804
    [Abstract] [Full Text] [Related]

  • 29. Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation.
    Wang Z, Shi X, Zhang H, Yu L, Cheng Y, Zhang H, Zhang H, Zhou J, Chen J, Shen X, Duan W.
    Eur J Med Chem; 2017 Oct 20; 139():128-152. PubMed ID: 28800453
    [Abstract] [Full Text] [Related]

  • 30. Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.
    Coope GJ, Atkinson AM, Allott C, McKerrecher D, Johnstone C, Pike KG, Holme PC, Vertigan H, Gill D, Coghlan MP, Leighton B.
    Br J Pharmacol; 2006 Oct 20; 149(3):328-35. PubMed ID: 16921397
    [Abstract] [Full Text] [Related]

  • 31. Glucokinase-activating ureas.
    Castelhano AL, Dong H, Fyfe MC, Gardner LS, Kamikozawa Y, Kurabayashi S, Nawano M, Ohashi R, Procter MJ, Qiu L, Rasamison CM, Schofield KL, Shah VK, Ueta K, Williams GM, Witter D, Yasuda K.
    Bioorg Med Chem Lett; 2005 Mar 01; 15(5):1501-4. PubMed ID: 15713416
    [Abstract] [Full Text] [Related]

  • 32. N-pyridin-2-yl benzamide analogues as allosteric activators of glucokinase: Design, synthesis, in vitro, in silico and in vivo evaluation.
    Grewal AS, Kharb R, Prasad DN, Dua JS, Lather V.
    Chem Biol Drug Des; 2019 Mar 01; 93(3):364-372. PubMed ID: 30369030
    [Abstract] [Full Text] [Related]

  • 33. Glucokinase activators in diabetes management.
    Coghlan M, Leighton B.
    Expert Opin Investig Drugs; 2008 Feb 01; 17(2):145-67. PubMed ID: 18230050
    [Abstract] [Full Text] [Related]

  • 34. Hepatic glycogen cycling contributes to glucose lowering effects of the glucokinase activator LCZ960.
    Laurent D, Yerby B, Zhang B, Chen XH, Gounarides J, Zhang J, Gao J, Bebernitz G, Duttaroy A.
    Eur J Pharmacol; 2013 Sep 05; 715(1-3):89-95. PubMed ID: 23816435
    [Abstract] [Full Text] [Related]

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  • 38. Discovery and structure-activity relationships of a novel class of quinazoline glucokinase activators.
    Iino T, Sasaki Y, Bamba M, Mitsuya M, Ohno A, Kamata K, Hosaka H, Maruki H, Futamura M, Yoshimoto R, Ohyama S, Sasaki K, Chiba M, Ohtake N, Nagata Y, Eiki J, Nishimura T.
    Bioorg Med Chem Lett; 2009 Oct 01; 19(19):5531-8. PubMed ID: 19726182
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  • 39.
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  • 40. Adenovirus-mediated expression of glucokinase in the liver as an adjuvant treatment for type 1 diabetes.
    Morral N, McEvoy R, Dong H, Meseck M, Altomonte J, Thung S, Woo SL.
    Hum Gene Ther; 2002 Sep 01; 13(13):1561-70. PubMed ID: 12228011
    [Abstract] [Full Text] [Related]

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