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179 related items for PubMed ID: 19751784

  • 1. CD147, a gamma-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2.
    Nahalkova J, Volkmann I, Aoki M, Winblad B, Bogdanovic N, Tjernberg LO, Behbahani H.
    Neurochem Int; 2010 Jan; 56(1):67-76. PubMed ID: 19751784
    [Abstract] [Full Text] [Related]

  • 2. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7499-504. PubMed ID: 15890777
    [Abstract] [Full Text] [Related]

  • 3. Gamma-secretase subunit composition and distribution in the presenilin wild-type and mutant mouse brain.
    Siman R, Salidas S.
    Neuroscience; 2004 May 24; 129(3):615-28. PubMed ID: 15541883
    [Abstract] [Full Text] [Related]

  • 4. The discovery and role of CD147 as a subunit of gamma-secretase complex.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Drug News Perspect; 2006 Apr 24; 19(3):133-8. PubMed ID: 16804564
    [Abstract] [Full Text] [Related]

  • 5. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
    Brijbassi S, Amtul Z, Newbigging S, Westaway D, St George-Hyslop P, Rozmahel RF.
    Neurobiol Dis; 2007 Feb 24; 25(2):291-6. PubMed ID: 17071095
    [Abstract] [Full Text] [Related]

  • 6. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 7. Regulation of gamma-secretase activity in Alzheimer's disease.
    Zhou S, Zhou H, Walian PJ, Jap BK.
    Biochemistry; 2007 Mar 13; 46(10):2553-63. PubMed ID: 17298085
    [Abstract] [Full Text] [Related]

  • 8. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H.
    Neurobiol Dis; 2007 Jul 13; 27(1):102-7. PubMed ID: 17560791
    [Abstract] [Full Text] [Related]

  • 9. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F.
    J Neurochem; 2009 Jul 13; 110(1):275-83. PubMed ID: 19457123
    [Abstract] [Full Text] [Related]

  • 10. Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease.
    Yu WH, Kumar A, Peterhoff C, Shapiro Kulnane L, Uchiyama Y, Lamb BT, Cuervo AM, Nixon RA.
    Int J Biochem Cell Biol; 2004 Dec 13; 36(12):2531-40. PubMed ID: 15325590
    [Abstract] [Full Text] [Related]

  • 11. Increased expression of the gamma-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury.
    Nadler Y, Alexandrovich A, Grigoriadis N, Hartmann T, Rao KS, Shohami E, Stein R.
    Glia; 2008 Apr 13; 56(5):552-67. PubMed ID: 18240300
    [Abstract] [Full Text] [Related]

  • 12. PS2 protein expression is upregulated by sex steroids in the cerebral cortex of aging mice.
    Ghosh S, Thakur MK.
    Neurochem Int; 2008 Feb 13; 52(3):363-7. PubMed ID: 17728018
    [Abstract] [Full Text] [Related]

  • 13. p53 is regulated by and regulates members of the gamma-secretase complex.
    Checler F, Dunys J, Pardossi-Piquard R, Alves da Costa C.
    Neurodegener Dis; 2010 Feb 13; 7(1-3):50-5. PubMed ID: 20160459
    [Abstract] [Full Text] [Related]

  • 14. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
    Laudon H, Winblad B, Näslund J.
    Physiol Behav; 2007 Sep 10; 92(1-2):115-20. PubMed ID: 17588625
    [Abstract] [Full Text] [Related]

  • 15. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.
    Nature; 2000 Jun 08; 405(6787):689-94. PubMed ID: 10864326
    [Abstract] [Full Text] [Related]

  • 16. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.
    Nature; 1999 Apr 08; 398(6727):513-7. PubMed ID: 10206644
    [Abstract] [Full Text] [Related]

  • 17. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.
    J Cell Biol; 2002 Aug 05; 158(3):551-61. PubMed ID: 12147673
    [Abstract] [Full Text] [Related]

  • 18. Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro.
    Hatchett CS, Tyler S, Armstrong D, Dawbarn D, Allen SJ.
    Brain Res; 2007 May 25; 1147():248-55. PubMed ID: 17349981
    [Abstract] [Full Text] [Related]

  • 19. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.
    J Neurochem; 2005 Sep 25; 94(5):1189-201. PubMed ID: 15992373
    [Abstract] [Full Text] [Related]

  • 20. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 25; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

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