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Journal Abstract Search

676 related items for PubMed ID: 19765582

  • 1. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y.
    Eur J Pharmacol; 2009 Nov 25; 623(1-3):14-21. PubMed ID: 19765582
    [Abstract] [Full Text] [Related]

  • 2. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.
    Fu H, Li W, Luo J, Lee NT, Li M, Tsim KW, Pang Y, Youdim MB, Han Y.
    Biochem Biophys Res Commun; 2008 Feb 15; 366(3):631-6. PubMed ID: 18039469
    [Abstract] [Full Text] [Related]

  • 3. Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.
    Parvathy S, Ehrlich M, Pedrini S, Diaz N, Refolo L, Buxbaum JD, Bogush A, Petanceska S, Gandy S.
    J Neurochem; 2004 Aug 15; 90(4):1005-10. PubMed ID: 15287907
    [Abstract] [Full Text] [Related]

  • 4. Cysteine proteases are the major beta-secretase in the regulated secretory pathway that provides most of the beta-amyloid in Alzheimer's disease: role of BACE 1 in the constitutive secretory pathway.
    Hook VY, Reisine TD.
    J Neurosci Res; 2003 Nov 01; 74(3):393-405. PubMed ID: 14598316
    [Abstract] [Full Text] [Related]

  • 5. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 6. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 01; 100(3):802-9. PubMed ID: 17156133
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  • 8. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
    Sheng B, Gong K, Niu Y, Liu L, Yan Y, Lu G, Zhang L, Hu M, Zhao N, Zhang X, Tang P, Gong Y.
    Free Radic Biol Med; 2009 May 15; 46(10):1362-75. PubMed ID: 19264123
    [Abstract] [Full Text] [Related]

  • 9. New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity.
    Yang HQ, Pan J, Ba MW, Sun ZK, Ma GZ, Lu GQ, Xiao Q, Chen SD.
    Eur J Neurosci; 2007 Jul 15; 26(2):381-91. PubMed ID: 17650113
    [Abstract] [Full Text] [Related]

  • 10. Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling.
    Züchner T, Perez-Polo JR, Schliebs R.
    J Neurosci Res; 2004 Jul 15; 77(2):250-7. PubMed ID: 15211591
    [Abstract] [Full Text] [Related]

  • 11. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.
    Proc Natl Acad Sci U S A; 2000 Aug 15; 97(17):9712-7. PubMed ID: 10931940
    [Abstract] [Full Text] [Related]

  • 12. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
    Peng Y, Jiang L, Lee DY, Schachter SC, Ma Z, Lemere CA.
    J Neurosci Res; 2006 Sep 15; 84(4):903-11. PubMed ID: 16862548
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  • 14. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.
    Nature; 1999 Dec 02; 402(6761):533-7. PubMed ID: 10591213
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  • 17. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.
    Neurobiol Dis; 2005 Nov 02; 20(2):625-37. PubMed ID: 15936948
    [Abstract] [Full Text] [Related]

  • 18. Evidence for dimeric BACE-mediated APP processing.
    Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U.
    Biochem Biophys Res Commun; 2010 Feb 26; 393(1):21-7. PubMed ID: 20097169
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  • 19. Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
    Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC, Lemere CA.
    Neuroscience; 2007 Dec 05; 150(2):386-95. PubMed ID: 17945434
    [Abstract] [Full Text] [Related]

  • 20. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
    Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU.
    J Neurochem; 2009 Dec 05; 111(6):1369-82. PubMed ID: 19804379
    [Abstract] [Full Text] [Related]

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