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Journal Abstract Search

467 related items for PubMed ID: 19788238

  • 1. Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4).
    Lafleur K, Huang D, Zhou T, Caflisch A, Nevado C.
    J Med Chem; 2009 Oct 22; 52(20):6433-46. PubMed ID: 19788238
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  • 2. High-throughput virtual screening using quantum mechanical probes: discovery of selective kinase inhibitors.
    Zhou T, Caflisch A.
    ChemMedChem; 2010 Jul 05; 5(7):1007-14. PubMed ID: 20540063
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  • 3. Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
    Lafleur K, Dong J, Huang D, Caflisch A, Nevado C.
    J Med Chem; 2013 Jan 10; 56(1):84-96. PubMed ID: 23253074
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  • 4. Structure-based tailoring of compound libraries for high-throughput screening: discovery of novel EphB4 kinase inhibitors.
    Kolb P, Kipouros CB, Huang D, Caflisch A.
    Proteins; 2008 Oct 10; 73(1):11-8. PubMed ID: 18384152
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  • 5. Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.
    Bardelle C, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2776-80. PubMed ID: 18434142
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  • 6. Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors.
    Bardelle C, Barlaam B, Brooks N, Coleman T, Cross D, Ducray R, Green I, Brempt CL, Olivier A, Read J.
    Bioorg Med Chem Lett; 2010 Nov 01; 20(21):6242-5. PubMed ID: 20850301
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  • 8. Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines.
    Bardelle C, Coleman T, Cross D, Davenport S, Kettle JG, Ko EJ, Leach AG, Mortlock A, Read J, Roberts NJ, Robins P, Williams EJ.
    Bioorg Med Chem Lett; 2008 Nov 01; 18(21):5717-21. PubMed ID: 18851911
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  • 9. Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4.
    Mitchell SA, Danca MD, Blomgren PA, Darrow JW, Currie KS, Kropf JE, Lee SH, Gallion SL, Xiong JM, Pippin DA, DeSimone RW, Brittelli DR, Eustice DC, Bourret A, Hill-Drzewi M, Maciejewski PM, Elkin LL.
    Bioorg Med Chem Lett; 2009 Dec 15; 19(24):6991-5. PubMed ID: 19879134
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  • 11. Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
    Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG.
    J Med Chem; 2008 Mar 27; 51(6):1637-48. PubMed ID: 18278858
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