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751 related items for PubMed ID: 19804380

  • 1. Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.
    Tan KR, Baur R, Charon S, Goeldner M, Sigel E.
    J Neurochem; 2009 Dec; 111(5):1264-73. PubMed ID: 19804380
    [Abstract] [Full Text] [Related]

  • 2. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 3. Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.
    Tan KR, Baur R, Gonthier A, Goeldner M, Sigel E.
    FEBS Lett; 2007 Oct 02; 581(24):4718-22. PubMed ID: 17854801
    [Abstract] [Full Text] [Related]

  • 4. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.
    Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H.
    Nature; 1999 Oct 21; 401(6755):796-800. PubMed ID: 10548105
    [Abstract] [Full Text] [Related]

  • 5. Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators.
    Tan KR, Gonthier A, Baur R, Ernst M, Goeldner M, Sigel E.
    J Biol Chem; 2007 Sep 07; 282(36):26316-25. PubMed ID: 17626010
    [Abstract] [Full Text] [Related]

  • 6. On the benzodiazepine binding pocket in GABAA receptors.
    Berezhnoy D, Nyfeler Y, Gonthier A, Schwob H, Goeldner M, Sigel E.
    J Biol Chem; 2004 Jan 30; 279(5):3160-8. PubMed ID: 14612433
    [Abstract] [Full Text] [Related]

  • 7. Potentiation of gamma-aminobutyric acid-induced chloride currents by various benzodiazepine site agonists with the alpha 1 gamma 2, beta 2 gamma 2 and alpha 1 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acid type A receptors.
    Im HK, Im WB, Hamilton BJ, Carter DB, Vonvoigtlander PF.
    Mol Pharmacol; 1993 Oct 30; 44(4):866-70. PubMed ID: 7901754
    [Abstract] [Full Text] [Related]

  • 8. Relative positioning of classical benzodiazepines to the γ2-subunit of GABAA receptors.
    Middendorp SJ, Hurni E, Schönberger M, Stein M, Pangerl M, Trauner D, Sigel E.
    ACS Chem Biol; 2014 Aug 15; 9(8):1846-53. PubMed ID: 24918742
    [Abstract] [Full Text] [Related]

  • 9. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
    Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.
    J Pharmacol Exp Ther; 2006 Dec 15; 319(3):1244-52. PubMed ID: 16971504
    [Abstract] [Full Text] [Related]

  • 10. Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site.
    Buhr A, Baur R, Malherbe P, Sigel E.
    Mol Pharmacol; 1996 Jun 15; 49(6):1080-4. PubMed ID: 8649346
    [Abstract] [Full Text] [Related]

  • 11. Flavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in mice.
    Fernandez SP, Mewett KN, Hanrahan JR, Chebib M, Johnston GA.
    Neuropharmacology; 2008 Oct 15; 55(5):900-7. PubMed ID: 18657554
    [Abstract] [Full Text] [Related]

  • 12. Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.
    Berezhnoy D, Baur R, Gonthier A, Foucaud B, Goeldner M, Sigel E.
    J Neurochem; 2005 Feb 15; 92(4):859-66. PubMed ID: 15686488
    [Abstract] [Full Text] [Related]

  • 13. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.
    Middendorp SJ, Maldifassi MC, Baur R, Sigel E.
    Neuropharmacology; 2015 Aug 15; 95():459-67. PubMed ID: 25963418
    [Abstract] [Full Text] [Related]

  • 14. Down-regulation of benzodiazepine binding to alpha 5 subunit-containing gamma-aminobutyric Acid(A) receptors in tolerant rat brain indicates particular involvement of the hippocampal CA1 region.
    Li M, Szabo A, Rosenberg HC.
    J Pharmacol Exp Ther; 2000 Nov 15; 295(2):689-96. PubMed ID: 11046107
    [Abstract] [Full Text] [Related]

  • 15. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
    McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ.
    Nat Neurosci; 2000 Jun 15; 3(6):587-92. PubMed ID: 10816315
    [Abstract] [Full Text] [Related]

  • 16. Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
    Giusti P, Ducić I, Puia G, Arban R, Walser A, Guidotti A, Costa E.
    J Pharmacol Exp Ther; 1993 Aug 15; 266(2):1018-28. PubMed ID: 8394902
    [Abstract] [Full Text] [Related]

  • 17. Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.
    Walters RJ, Hadley SH, Morris KD, Amin J.
    Nat Neurosci; 2000 Dec 15; 3(12):1274-81. PubMed ID: 11100148
    [Abstract] [Full Text] [Related]

  • 18. Alterations of the benzodiazepine site of rat alpha 6 beta 2 gamma 2-GABAA receptor by replacement of several divergent amino-terminal regions with the alpha 1 counterparts.
    Im WB, Pregenzer JF, Binder JA, Alberts GL, Im HK.
    Br J Pharmacol; 1997 Feb 15; 120(4):559-64. PubMed ID: 9051290
    [Abstract] [Full Text] [Related]

  • 19. Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
    Bowser DN, Wagner DA, Czajkowski C, Cromer BA, Parker MW, Wallace RH, Harkin LA, Mulley JC, Marini C, Berkovic SF, Williams DA, Jones MV, Petrou S.
    Proc Natl Acad Sci U S A; 2002 Nov 12; 99(23):15170-5. PubMed ID: 12415111
    [Abstract] [Full Text] [Related]

  • 20. Towards better benzodiazepines.
    Wisden W, Stephens DN.
    Nature; 1999 Oct 21; 401(6755):751-2. PubMed ID: 10548094
    [No Abstract] [Full Text] [Related]

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