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785 related items for PubMed ID: 19835884

  • 1. Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.
    Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC.
    J Mol Biol; 2009 Dec 18; 394(5):878-92. PubMed ID: 19835884
    [Abstract] [Full Text] [Related]

  • 2. Insulin receptor structure and its implications for the IGF-1 receptor.
    Lawrence MC, McKern NM, Ward CW.
    Curr Opin Struct Biol; 2007 Dec 18; 17(6):699-705. PubMed ID: 17851071
    [Abstract] [Full Text] [Related]

  • 3. Structural insights into ligand-induced activation of the insulin receptor.
    Ward C, Lawrence M, Streltsov V, Garrett T, McKern N, Lou MZ, Lovrecz G, Adams T.
    Acta Physiol (Oxf); 2008 Jan 18; 192(1):3-9. PubMed ID: 18171424
    [Abstract] [Full Text] [Related]

  • 4. Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.
    Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW.
    Nature; 1998 Jul 23; 394(6691):395-9. PubMed ID: 9690478
    [Abstract] [Full Text] [Related]

  • 5. [The structural organization of binding determinants in insulin-like growth factor-I (IGF-I) molecule].
    Kolychev AP.
    Zh Evol Biokhim Fiziol; 2010 Jul 23; 46(1):74-94. PubMed ID: 20297673
    [Abstract] [Full Text] [Related]

  • 6. Structure of the insulin receptor ectodomain reveals a folded-over conformation.
    McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW.
    Nature; 2006 Sep 14; 443(7108):218-21. PubMed ID: 16957736
    [Abstract] [Full Text] [Related]

  • 7. Model for the complex between the insulin-like growth factor I and its receptor: towards designing antagonists for the IGF-1 receptor.
    Epa VC, Ward CW.
    Protein Eng Des Sel; 2006 Aug 14; 19(8):377-84. PubMed ID: 16772308
    [Abstract] [Full Text] [Related]

  • 8. Cys 786 and Cys 776 in the posttranslational processing of the insulin and IGF-I receptors.
    Maggi D, Cordera R.
    Biochem Biophys Res Commun; 2001 Jan 26; 280(3):836-41. PubMed ID: 11162597
    [Abstract] [Full Text] [Related]

  • 9. Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.
    Denley A, Carroll JM, Brierley GV, Cosgrove L, Wallace J, Forbes B, Roberts CT.
    Mol Cell Biol; 2007 May 26; 27(10):3569-77. PubMed ID: 17325037
    [Abstract] [Full Text] [Related]

  • 10. Differential regulation of signaling pathways for insulin and insulin-like growth factor I.
    Lopaczynski W.
    Acta Biochim Pol; 1999 May 26; 46(1):51-60. PubMed ID: 10453981
    [Abstract] [Full Text] [Related]

  • 11. Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells.
    Johansson GS, Arnqvist HJ.
    Am J Physiol Endocrinol Metab; 2006 Nov 26; 291(5):E1124-30. PubMed ID: 16803852
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and characterization of biotinylated forms of insulin-like growth factor-1: topographical evaluation of the IGF-1/IGFBP-2 AND IGFBP-3 interface.
    Robinson SA, Rosenzweig SA.
    Biochemistry; 2004 Sep 14; 43(36):11533-45. PubMed ID: 15350139
    [Abstract] [Full Text] [Related]

  • 13. Increased levels of insulin and insulin-like growth factor-1 hybrid receptors and decreased glycosylation of the insulin receptor alpha- and beta-subunits in scrapie-infected neuroblastoma N2a cells.
    Nielsen D, Gyllberg H, Ostlund P, Bergman T, Bedecs K.
    Biochem J; 2004 Jun 01; 380(Pt 2):571-9. PubMed ID: 15025560
    [Abstract] [Full Text] [Related]

  • 14. Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.
    Wood ER, Shewchuk L, Hassel A, Nichols J, Truesdale AT, Smith D, Carter HL, Weaver K, Barrett G, Leesnitzer T, Alvarez E, Bardera AI, Alamillo A, Cantizani J, Martin J, Smith GK, Jensen DE, Xie H, Mook R, Kumar R, Kuntz K.
    Biochem Pharmacol; 2009 Dec 15; 78(12):1438-47. PubMed ID: 19665448
    [Abstract] [Full Text] [Related]

  • 15. A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.
    Menting JG, Ward CW, Margetts MB, Lawrence MC.
    Biochemistry; 2009 Jun 16; 48(23):5492-500. PubMed ID: 19459609
    [Abstract] [Full Text] [Related]

  • 16. Influence of placental mannose/n-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors.
    Nedic O, Filimonovic D, Mikovic Z, Masnikosa R.
    Biochemistry (Mosc); 2011 Sep 16; 76(9):1003-8. PubMed ID: 22082268
    [Abstract] [Full Text] [Related]

  • 17. Molecular mechanisms underlying insulin-like growth factor action: How mutations in the GH: IGF axis lead to short stature.
    Forbes BE.
    Pediatr Endocrinol Rev; 2011 Jun 16; 8(4):374-81. PubMed ID: 21972777
    [Abstract] [Full Text] [Related]

  • 18. Characterisation of receptors for IGF-I and insulin; evidence for hybrid insulin/IGF-I receptor in human coronary artery endothelial cells.
    Chisalita SI, Nitert MD, Arnqvist HJ.
    Growth Horm IGF Res; 2006 Aug 16; 16(4):258-66. PubMed ID: 16914341
    [Abstract] [Full Text] [Related]

  • 19. Ligand-induced conformational change in the minimized insulin receptor.
    Schlein M, Havelund S, Kristensen C, Dunn MF, Kaarsholm NC.
    J Mol Biol; 2000 Oct 20; 303(2):161-9. PubMed ID: 11023783
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of insulin-like growth factor I receptor tyrosine kinase by ethanol.
    Rubin R, Harrison R, Chen XF, Corzitotto J, Hoek JB, Hallak H.
    Biochem Pharmacol; 2004 Nov 15; 68(10):2009-17. PubMed ID: 15476672
    [Abstract] [Full Text] [Related]

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