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102 related items for PubMed ID: 19853978

  • 1. The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine.
    Ramos-Lima FJ, Moneo V, Quiroga AG, Carnero A, Navarro-Ranninger C.
    Eur J Med Chem; 2010 Jan; 45(1):134-41. PubMed ID: 19853978
    [Abstract] [Full Text] [Related]

  • 2. Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.
    Farrell N, Kelland LR, Roberts JD, Van Beusichem M.
    Cancer Res; 1992 Sep 15; 52(18):5065-72. PubMed ID: 1516063
    [Abstract] [Full Text] [Related]

  • 3. New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin.
    Ramos-Lima FJ, Quiroga AG, García-Serrelde B, Blanco F, Carnero A, Navarro-Ranninger C.
    J Med Chem; 2007 May 03; 50(9):2194-9. PubMed ID: 17407274
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  • 4. Structure-activity relationship of new trans-platinum(II) and (IV) complexes with cyclohexylamine. Interference with cell cycle progression and induction of cell death.
    González-Vadillo AM, Alvarez-Valdés A, Moneo V, Blanco F, Díaz RG, Carnero A, Navarro-Ranninger C.
    J Inorg Biochem; 2007 Apr 03; 101(4):551-8. PubMed ID: 17257684
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  • 5. DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines.
    Kasparkova J, Marini V, Najajreh Y, Gibson D, Brabec V.
    Biochemistry; 2003 May 27; 42(20):6321-32. PubMed ID: 12755637
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  • 6. Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine.
    Martínez A, Lorenzo J, Prieto MJ, de Llorens R, Font-Bardia M, Solans X, Avilés FX, Moreno V.
    Chembiochem; 2005 Nov 27; 6(11):2068-77. PubMed ID: 16222727
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  • 7. Recognition of DNA modified by trans-[PtClNH(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex.
    Stehlíková K, Kaspárková J, Nováková O, Martínez A, Moreno V, Brabec V.
    FEBS J; 2006 Jan 27; 273(2):301-14. PubMed ID: 16403018
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  • 8. Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy.
    Sbovata SM, Bettio F, Mozzon M, Bertani R, Venzo A, Benetollo F, Michelin RA, Gandin V, Marzano C.
    J Med Chem; 2007 Sep 20; 50(19):4775-84. PubMed ID: 17713897
    [Abstract] [Full Text] [Related]

  • 9. Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine.
    Halámiková A, Heringová P, Kaspárková J, Intini FP, Natile G, Nemirovski A, Gibson D, Brabec V.
    J Inorg Biochem; 2008 Sep 20; 102(5-6):1077-89. PubMed ID: 18237783
    [Abstract] [Full Text] [Related]

  • 10. DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.
    Kasparkova J, Novakova O, Farrell N, Brabec V.
    Biochemistry; 2003 Jan 28; 42(3):792-800. PubMed ID: 12534292
    [Abstract] [Full Text] [Related]

  • 11. Cationic nonsymmetric transplatinum complexes with piperidinopiperidine ligands. Preparation, characterization, in vitro cytotoxicity, in vivo toxicity, and anticancer efficacy studies.
    Najajreh Y, Khazanov E, Jawbry S, Ardeli-Tzaraf Y, Perez JM, Kasparkova J, Brabec V, Barenholz Y, Gibson D.
    J Med Chem; 2006 Jul 27; 49(15):4665-73. PubMed ID: 16854072
    [Abstract] [Full Text] [Related]

  • 12. Studies on activities, cell uptake and DNA binding of four trans-planaramineplatinum(II) complexes of the form: trans-PtL(NH3)Cl2, where L=2-hydroxypyridine, imidazole, 3-hydroxypyridine and imidazo(1,2-alpha)pyridine.
    Huq F, Yu JQ, Daghriri H, Beale P.
    J Inorg Biochem; 2004 Aug 27; 98(8):1261-70. PubMed ID: 15271501
    [Abstract] [Full Text] [Related]

  • 13. Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines.
    Martínez A, Lorenzo J, Prieto MJ, Font-Bardia M, Solans X, Avilés FX, Moreno V.
    Bioorg Med Chem; 2007 Jan 15; 15(2):969-79. PubMed ID: 17088064
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  • 15. Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
    Hagopian GS, Mills GB, Khokhar AR, Bast RC, Siddik ZH.
    Clin Cancer Res; 1999 Mar 15; 5(3):655-63. PubMed ID: 10100719
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  • 19. Synthesis and characterization of platinum(II) oxadiazoline complexes and their in vitro antitumor activity in platinum-sensitive and -resistant cancer cell lines.
    Coley HM, Sarju J, Wagner G.
    J Med Chem; 2008 Jan 10; 51(1):135-41. PubMed ID: 18072719
    [Abstract] [Full Text] [Related]

  • 20. Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands.
    Zorbas-Seifried S, Jakupec MA, Kukushkin NV, Groessl M, Hartinger CG, Semenova O, Zorbas H, Kukushkin VY, Keppler BK.
    Mol Pharmacol; 2007 Jan 10; 71(1):357-65. PubMed ID: 17050805
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