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Journal Abstract Search

136 related items for PubMed ID: 19854250

  • 1. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.
    Saha S, New LS, Ho HK, Chui WK, Chan EC.
    Toxicol Lett; 2010 Feb 01; 192(2):141-9. PubMed ID: 19854250
    [Abstract] [Full Text] [Related]

  • 2. Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes.
    Saha S, New LS, Ho HK, Chui WK, Chan EC.
    Toxicol Lett; 2010 Jun 02; 195(2-3):135-41. PubMed ID: 20307632
    [Abstract] [Full Text] [Related]

  • 3. Identification of glutathione conjugates of troglitazone in human hepatocytes.
    Prabhu S, Fackett A, Lloyd S, McClellan HA, Terrell CM, Silber PM, Li AP.
    Chem Biol Interact; 2002 Nov 10; 142(1-2):83-97. PubMed ID: 12399157
    [Abstract] [Full Text] [Related]

  • 4. Thiazolidinedione bioactivation: a comparison of the bioactivation potentials of troglitazone, rosiglitazone, and pioglitazone using stable isotope-labeled analogues and liquid chromatography tandem mass spectrometry.
    Alvarez-Sanchez R, Montavon F, Hartung T, Pähler A.
    Chem Res Toxicol; 2006 Aug 10; 19(8):1106-16. PubMed ID: 16918252
    [Abstract] [Full Text] [Related]

  • 5. Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties.
    Saha S, Chan DS, Lee CY, Wong W, New LS, Chui WK, Yap CW, Chan EC, Ho HK.
    Eur J Pharmacol; 2012 Dec 15; 697(1-3):13-23. PubMed ID: 23041271
    [Abstract] [Full Text] [Related]

  • 6. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved.
    He K, Talaat RE, Pool WF, Reily MD, Reed JE, Bridges AJ, Woolf TF.
    Drug Metab Dispos; 2004 Jun 15; 32(6):639-46. PubMed ID: 15155556
    [Abstract] [Full Text] [Related]

  • 7. Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.
    Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA.
    Chem Res Toxicol; 2001 Jan 15; 14(1):62-70. PubMed ID: 11170509
    [Abstract] [Full Text] [Related]

  • 8. Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo.
    Tettey JN, Maggs JL, Rapeport WG, Pirmohamed M, Park BK.
    Chem Res Toxicol; 2001 Aug 15; 14(8):965-74. PubMed ID: 11511170
    [Abstract] [Full Text] [Related]

  • 9. Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
    Madsen KG, Grönberg G, Skonberg C, Jurva U, Hansen SH, Olsen J.
    Chem Res Toxicol; 2008 Oct 15; 21(10):2035-41. PubMed ID: 18788755
    [Abstract] [Full Text] [Related]

  • 10. Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review.
    Masubuchi Y.
    Drug Metab Pharmacokinet; 2006 Oct 15; 21(5):347-56. PubMed ID: 17072088
    [Abstract] [Full Text] [Related]

  • 11. Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand.
    Nonaka M, Tazuma S, Hyogo H, Kanno K, Chayama K.
    J Gastroenterol Hepatol; 2008 Jul 15; 23(7 Pt 2):e198-206. PubMed ID: 17868335
    [Abstract] [Full Text] [Related]

  • 12. In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry.
    Liu DQ, Karanam BV, Doss GA, Sidler RR, Vincent SH, Hop CE.
    Drug Metab Dispos; 2004 Sep 15; 32(9):1023-31. PubMed ID: 15319345
    [Abstract] [Full Text] [Related]

  • 13. Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation.
    Lee JK, Marion TL, Abe K, Lim C, Pollock GM, Brouwer KL.
    J Pharmacol Exp Ther; 2010 Jan 15; 332(1):26-34. PubMed ID: 19801447
    [Abstract] [Full Text] [Related]

  • 14. Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.
    Guo L, Zhang L, Sun Y, Muskhelishvili L, Blann E, Dial S, Shi L, Schroth G, Dragan YP.
    Mol Divers; 2006 Aug 15; 10(3):349-60. PubMed ID: 17031537
    [Abstract] [Full Text] [Related]

  • 15. Metabolic flux profiling of reaction modules in liver drug transformation.
    Yoon J, Lee K.
    Pac Symp Biocomput; 2007 Aug 15; ():193-204. PubMed ID: 17990492
    [Abstract] [Full Text] [Related]

  • 16. New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines.
    Colin C, Salamone S, Grillier-Vuissoz I, Boisbrun M, Kuntz S, Lecomte J, Chapleur Y, Flament S.
    Breast Cancer Res Treat; 2010 Nov 15; 124(1):101-10. PubMed ID: 20054646
    [Abstract] [Full Text] [Related]

  • 17. Gene expression analysis of troglitazone reveals its impact on multiple pathways in cell culture: a case for in vitro platforms combined with gene expression analysis for early (idiosyncratic) toxicity screening.
    Vansant G, Pezzoli P, Saiz R, Birch A, Duffy C, Ferre F, Monforte J.
    Int J Toxicol; 2006 Nov 15; 25(2):85-94. PubMed ID: 16597547
    [Abstract] [Full Text] [Related]

  • 18. Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities.
    Ong MM, Latchoumycandane C, Boelsterli UA.
    Toxicol Sci; 2007 May 15; 97(1):205-13. PubMed ID: 17150972
    [Abstract] [Full Text] [Related]

  • 19. In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly isolated hepatocytes.
    Uchiyama M, Koda H, Fischer T, Mueller J, Yamamura N, Oguchi M, Iwabuchi H, Okazaki O, Izumi T.
    Drug Metab Dispos; 2011 Jul 15; 39(7):1311-9. PubMed ID: 21511943
    [Abstract] [Full Text] [Related]

  • 20. Metabolism of troglitazone in hepatocytes isolated from experimentally induced diabetic rats.
    Meechan AJ, Henderson C, Bates CD, Grant MH, Tettey JN.
    J Pharm Pharmacol; 2006 Oct 15; 58(10):1359-65. PubMed ID: 17034659
    [Abstract] [Full Text] [Related]

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