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Journal Abstract Search

234 related items for PubMed ID: 19884011

  • 1. Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1.
    Koeberle A, Haberl EM, Rossi A, Pergola C, Dehm F, Northoff H, Troschuetz R, Sautebin L, Werz O.
    Bioorg Med Chem; 2009 Dec 01; 17(23):7924-32. PubMed ID: 19884011
    [Abstract] [Full Text] [Related]

  • 2. The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
    Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O.
    J Pharmacol Exp Ther; 2010 Mar 01; 332(3):840-8. PubMed ID: 19934399
    [Abstract] [Full Text] [Related]

  • 3. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.
    Karg EM, Luderer S, Pergola C, Bühring U, Rossi A, Northoff H, Sautebin L, Troschütz R, Werz O.
    J Med Chem; 2009 Jun 11; 52(11):3474-83. PubMed ID: 19492852
    [Abstract] [Full Text] [Related]

  • 4. Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.
    Schaible AM, Traber H, Temml V, Noha SM, Filosa R, Peduto A, Weinigel C, Barz D, Schuster D, Werz O.
    Biochem Pharmacol; 2013 Aug 15; 86(4):476-86. PubMed ID: 23623753
    [Abstract] [Full Text] [Related]

  • 5. Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation.
    Bruno F, Errico S, Pace S, Nawrozkij MB, Mkrtchyan AS, Guida F, Maisto R, Olgaç A, D'Amico M, Maione S, De Rosa M, Banoglu E, Werz O, Fiorentino A, Filosa R.
    Eur J Med Chem; 2018 Jul 15; 155():946-960. PubMed ID: 30015253
    [Abstract] [Full Text] [Related]

  • 6. Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.
    Koeberle A, Siemoneit U, Bühring U, Northoff H, Laufer S, Albrecht W, Werz O.
    J Pharmacol Exp Ther; 2008 Sep 15; 326(3):975-82. PubMed ID: 18550688
    [Abstract] [Full Text] [Related]

  • 7. Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.
    Mbalaviele G, Pauley AM, Shaffer AF, Zweifel BS, Mathialagan S, Mnich SJ, Nemirovskiy OV, Carter J, Gierse JK, Wang JL, Vazquez ML, Moore WM, Masferrer JL.
    Biochem Pharmacol; 2010 May 15; 79(10):1445-54. PubMed ID: 20067770
    [Abstract] [Full Text] [Related]

  • 8. Pyrrole alkanoic acid derivatives as nuisance inhibitors of microsomal prostaglandin E2 synthase-1.
    Wiegard A, Hanekamp W, Griessbach K, Fabian J, Lehr M.
    Eur J Med Chem; 2012 Feb 15; 48():153-63. PubMed ID: 22209272
    [Abstract] [Full Text] [Related]

  • 9. Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.
    Wang J, Limburg D, Carter J, Mbalaviele G, Gierse J, Vazquez M.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1604-9. PubMed ID: 20144869
    [Abstract] [Full Text] [Related]

  • 10. Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
    Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O.
    J Med Chem; 2008 Dec 25; 51(24):8068-76. PubMed ID: 19053751
    [Abstract] [Full Text] [Related]

  • 11. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
    Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D.
    J Pharmacol Exp Ther; 2008 Sep 25; 326(3):754-63. PubMed ID: 18524979
    [Abstract] [Full Text] [Related]

  • 12. Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1.
    Koeberle A, Pollastro F, Northoff H, Werz O.
    Br J Pharmacol; 2009 Mar 25; 156(6):952-61. PubMed ID: 19298395
    [Abstract] [Full Text] [Related]

  • 13. Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.
    Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML, Patrignani P.
    Biochem Pharmacol; 2010 Apr 01; 79(7):974-81. PubMed ID: 19925781
    [Abstract] [Full Text] [Related]

  • 14. Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.
    Shang E, Wu Y, Liu P, Liu Y, Zhu W, Deng X, He C, He S, Li C, Lai L.
    Bioorg Med Chem Lett; 2014 Jun 15; 24(12):2764-7. PubMed ID: 24794107
    [Abstract] [Full Text] [Related]

  • 15. Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid.
    Lee K, Pham VC, Choi MJ, Kim KJ, Lee KT, Han SG, Yu YG, Lee JY.
    Bioorg Med Chem Lett; 2013 Jan 01; 23(1):75-80. PubMed ID: 23218602
    [Abstract] [Full Text] [Related]

  • 16. Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review.
    Koeberle A, Werz O.
    Curr Med Chem; 2009 Jan 01; 16(32):4274-96. PubMed ID: 19754418
    [Abstract] [Full Text] [Related]

  • 17. Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.
    De Simone R, Chini MG, Bruno I, Riccio R, Mueller D, Werz O, Bifulco G.
    J Med Chem; 2011 Mar 24; 54(6):1565-75. PubMed ID: 21323313
    [Abstract] [Full Text] [Related]

  • 18. Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
    Riendeau D, Aspiotis R, Ethier D, Gareau Y, Grimm EL, Guay J, Guiral S, Juteau H, Mancini JA, Méthot N, Rubin J, Friesen RW.
    Bioorg Med Chem Lett; 2005 Jul 15; 15(14):3352-5. PubMed ID: 15953724
    [Abstract] [Full Text] [Related]

  • 19. Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).
    Waltenberger B, Wiechmann K, Bauer J, Markt P, Noha SM, Wolber G, Rollinger JM, Werz O, Schuster D, Stuppner H.
    J Med Chem; 2011 May 12; 54(9):3163-74. PubMed ID: 21466167
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense.
    Siemoneit U, Koeberle A, Rossi A, Dehm F, Verhoff M, Reckel S, Maier TJ, Jauch J, Northoff H, Bernhard F, Doetsch V, Sautebin L, Werz O.
    Br J Pharmacol; 2011 Jan 12; 162(1):147-62. PubMed ID: 20840544
    [Abstract] [Full Text] [Related]

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