These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

386 related items for PubMed ID: 19940843

  • 1. Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.
    Leach K, Loiacono RE, Felder CC, McKinzie DL, Mogg A, Shaw DB, Sexton PM, Christopoulos A.
    Neuropsychopharmacology; 2010 Mar; 35(4):855-69. PubMed ID: 19940843
    [Abstract] [Full Text] [Related]

  • 2. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).
    Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A.
    Mol Pharmacol; 2008 Oct; 74(4):1119-31. PubMed ID: 18628403
    [Abstract] [Full Text] [Related]

  • 3. Impact of species variability and 'probe-dependence' on the detection and in vivo validation of allosteric modulation at the M4 muscarinic acetylcholine receptor.
    Suratman S, Leach K, Sexton P, Felder C, Loiacono R, Christopoulos A.
    Br J Pharmacol; 2011 Apr; 162(7):1659-70. PubMed ID: 21198541
    [Abstract] [Full Text] [Related]

  • 4. Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects.
    Valant C, Felder CC, Sexton PM, Christopoulos A.
    Mol Pharmacol; 2012 Jan; 81(1):41-52. PubMed ID: 21989256
    [Abstract] [Full Text] [Related]

  • 5. Development of a radioligand, [(3)H]LY2119620, to probe the human M(2) and M(4) muscarinic receptor allosteric binding sites.
    Schober DA, Croy CH, Xiao H, Christopoulos A, Felder CC.
    Mol Pharmacol; 2014 Jul; 86(1):116-23. PubMed ID: 24807966
    [Abstract] [Full Text] [Related]

  • 6. Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors.
    Jakubík J, Randáková A, El-Fakahany EE, Dolezal V.
    BMC Pharmacol; 2009 Dec 28; 9():15. PubMed ID: 20038295
    [Abstract] [Full Text] [Related]

  • 7. Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.
    Chan WY, McKinzie DL, Bose S, Mitchell SN, Witkin JM, Thompson RC, Christopoulos A, Lazareno S, Birdsall NJ, Bymaster FP, Felder CC.
    Proc Natl Acad Sci U S A; 2008 Aug 05; 105(31):10978-83. PubMed ID: 18678919
    [Abstract] [Full Text] [Related]

  • 8.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 9. Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.
    Nawaratne V, Leach K, Felder CC, Sexton PM, Christopoulos A.
    J Biol Chem; 2010 Jun 18; 285(25):19012-21. PubMed ID: 20406819
    [Abstract] [Full Text] [Related]

  • 10. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.
    Berizzi AE, Gentry PR, Rueda P, Den Hoedt S, Sexton PM, Langmead CJ, Christopoulos A.
    Mol Pharmacol; 2016 Oct 18; 90(4):427-36. PubMed ID: 27461343
    [Abstract] [Full Text] [Related]

  • 11. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.
    Croy CH, Schober DA, Xiao H, Quets A, Christopoulos A, Felder CC.
    Mol Pharmacol; 2014 Jul 18; 86(1):106-15. PubMed ID: 24807965
    [Abstract] [Full Text] [Related]

  • 12. Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.
    Lazareno S, Birdsall B, Fukazawa T, Gharagozloo P, Hashimoto T, Kuwano H, Popham A, Sugimoto M, Birdsall NJ.
    Life Sci; 1999 Jul 18; 64(6-7):519-26. PubMed ID: 10069518
    [Abstract] [Full Text] [Related]

  • 13. Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.
    Huynh T, Valant C, Crosby IT, Sexton PM, Christopoulos A, Capuano B.
    J Med Chem; 2013 Oct 24; 56(20):8196-200. PubMed ID: 24074052
    [Abstract] [Full Text] [Related]

  • 14. Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.
    May LT, Avlani VA, Langmead CJ, Herdon HJ, Wood MD, Sexton PM, Christopoulos A.
    Mol Pharmacol; 2007 Aug 24; 72(2):463-76. PubMed ID: 17525129
    [Abstract] [Full Text] [Related]

  • 15. The muscarinic acetylcholine receptor agonist BuTAC mediates antipsychotic-like effects via the M4 subtype.
    Watt ML, Rorick-Kehn L, Shaw DB, Knitowski KM, Quets AT, Chesterfield AK, McKinzie DL, Felder CC.
    Neuropsychopharmacology; 2013 Dec 24; 38(13):2717-26. PubMed ID: 23907402
    [Abstract] [Full Text] [Related]

  • 16. Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors.
    Lanzafame AA, Sexton PM, Christopoulos A.
    Mol Pharmacol; 2006 Aug 24; 70(2):736-46. PubMed ID: 16709648
    [Abstract] [Full Text] [Related]

  • 17. Interaction of anandamide with the M(1) and M(4) muscarinic acetylcholine receptors.
    Christopoulos A, Wilson K.
    Brain Res; 2001 Oct 05; 915(1):70-8. PubMed ID: 11578621
    [Abstract] [Full Text] [Related]

  • 18. The muscarinic M(4) receptor is the functionally predominant subtype in rat and mouse striatum as demonstrated using [(35)S] GTPγS binding.
    Chapman KL, Vaswani D, Hendry N, Langmead CJ, Kew JN, Watson JM.
    Eur J Pharmacol; 2011 Feb 10; 652(1-3):1-6. PubMed ID: 21114972
    [Abstract] [Full Text] [Related]

  • 19. Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M₁ muscarinic acetylcholine receptor.
    Keov P, Valant C, Devine SM, Lane JR, Scammells PJ, Sexton PM, Christopoulos A.
    Mol Pharmacol; 2013 Sep 10; 84(3):425-37. PubMed ID: 23798605
    [Abstract] [Full Text] [Related]

  • 20. Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor.
    Khajehali E, Valant C, Jörg M, Tobin AB, Conn PJ, Lindsley CW, Sexton PM, Scammells PJ, Christopoulos A.
    Biochem Pharmacol; 2018 Aug 10; 154():243-254. PubMed ID: 29777683
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 20.