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653 related items for PubMed ID: 19969067

  • 1. Oxidative stress in ALS: key role in motor neuron injury and therapeutic target.
    Barber SC, Shaw PJ.
    Free Radic Biol Med; 2010 Mar 01; 48(5):629-41. PubMed ID: 19969067
    [Abstract] [Full Text] [Related]

  • 2. Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.
    Barber SC, Mead RJ, Shaw PJ.
    Biochim Biophys Acta; 2006 Mar 01; 1762(11-12):1051-67. PubMed ID: 16713195
    [Abstract] [Full Text] [Related]

  • 3. Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.
    Kirby J, Halligan E, Baptista MJ, Allen S, Heath PR, Holden H, Barber SC, Loynes CA, Wood-Allum CA, Lunec J, Shaw PJ.
    Brain; 2005 Jul 01; 128(Pt 7):1686-706. PubMed ID: 15872021
    [Abstract] [Full Text] [Related]

  • 4. Depletion of reduced glutathione enhances motor neuron degeneration in vitro and in vivo.
    Chi L, Ke Y, Luo C, Gozal D, Liu R.
    Neuroscience; 2007 Feb 09; 144(3):991-1003. PubMed ID: 17150307
    [Abstract] [Full Text] [Related]

  • 5. Mutant SOD1-induced neuronal toxicity is mediated by increased mitochondrial superoxide levels.
    Zimmerman MC, Oberley LW, Flanagan SW.
    J Neurochem; 2007 Aug 09; 102(3):609-18. PubMed ID: 17394531
    [Abstract] [Full Text] [Related]

  • 6. Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress.
    Cookson MR, Menzies FM, Manning P, Eggett CJ, Figlewicz DA, McNeil CJ, Shaw PJ.
    Amyotroph Lateral Scler Other Motor Neuron Disord; 2002 Jun 09; 3(2):75-85. PubMed ID: 12215229
    [Abstract] [Full Text] [Related]

  • 7. Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1G93A mutant mice.
    Bakshi R, Xu Y, Mueller KA, Chen X, Granucci E, Paganoni S, Sadri-Vakili G, Schwarzschild MA.
    Mol Cell Neurosci; 2018 Oct 09; 92():12-16. PubMed ID: 29928993
    [Abstract] [Full Text] [Related]

  • 8. Detection method of the adjacent motor neuronal death in an in vitro co-culture model of familial ALS-associated Cu/Zn superoxide dismutase.
    Park KS, Kim HJ, Choi WJ, Kim M, Lee KW.
    Biotechnol Lett; 2004 Aug 09; 26(15):1201-5. PubMed ID: 15289674
    [Abstract] [Full Text] [Related]

  • 9. Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.
    Holasek SS, Wengenack TM, Kandimalla KK, Montano C, Gregor DM, Curran GL, Poduslo JF.
    Brain Res; 2005 May 31; 1045(1-2):185-98. PubMed ID: 15910777
    [Abstract] [Full Text] [Related]

  • 10. ALS: a disease of motor neurons and their nonneuronal neighbors.
    Boillée S, Vande Velde C, Cleveland DW.
    Neuron; 2006 Oct 05; 52(1):39-59. PubMed ID: 17015226
    [Abstract] [Full Text] [Related]

  • 11. Mitochondrial dysfunction and its role in motor neuron degeneration in ALS.
    Manfredi G, Xu Z.
    Mitochondrion; 2005 Apr 05; 5(2):77-87. PubMed ID: 16050975
    [Abstract] [Full Text] [Related]

  • 12. Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.
    Jaarsma D, Haasdijk ED, Grashorn JA, Hawkins R, van Duijn W, Verspaget HW, London J, Holstege JC.
    Neurobiol Dis; 2000 Dec 05; 7(6 Pt B):623-43. PubMed ID: 11114261
    [Abstract] [Full Text] [Related]

  • 13. [Development of motor neuron restorative therapy in amyotrophic lateral sclerosis using hepatocyte growth factor].
    Aoki M, Warita H, Suzuki N, Itoyama Y.
    Rinsho Shinkeigaku; 2009 Nov 05; 49(11):814-7. PubMed ID: 20030218
    [Abstract] [Full Text] [Related]

  • 14. Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice.
    Wong M, Martin LJ.
    Hum Mol Genet; 2010 Jun 01; 19(11):2284-302. PubMed ID: 20223753
    [Abstract] [Full Text] [Related]

  • 15. A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice.
    Teuling E, van Dis V, Wulf PS, Haasdijk ED, Akhmanova A, Hoogenraad CC, Jaarsma D.
    Hum Mol Genet; 2008 Sep 15; 17(18):2849-62. PubMed ID: 18579581
    [Abstract] [Full Text] [Related]

  • 16. Motor neuron dysfunction in a mouse model of ALS: gender-dependent effect of P2X7 antagonism.
    Cervetto C, Frattaroli D, Maura G, Marcoli M.
    Toxicology; 2013 Sep 06; 311(1-2):69-77. PubMed ID: 23583883
    [Abstract] [Full Text] [Related]

  • 17. Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.
    Goodall EF, Morrison KE.
    Expert Rev Mol Med; 2006 May 24; 8(11):1-22. PubMed ID: 16723044
    [Abstract] [Full Text] [Related]

  • 18. Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.
    Dupuis L, Gonzalez de Aguilar JL, Oudart H, de Tapia M, Barbeito L, Loeffler JP.
    Neurodegener Dis; 2004 May 24; 1(6):245-54. PubMed ID: 16908975
    [Abstract] [Full Text] [Related]

  • 19. Role of complement in motor neuron disease: animal models and therapeutic potential of complement inhibitors.
    Woodruff TM, Costantini KJ, Taylor SM, Noakes PG.
    Adv Exp Med Biol; 2008 May 24; 632():143-58. PubMed ID: 19025120
    [Abstract] [Full Text] [Related]

  • 20. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis.
    Rothstein JD.
    Ann Neurol; 2009 Jan 24; 65 Suppl 1():S3-9. PubMed ID: 19191304
    [Abstract] [Full Text] [Related]

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