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352 related items for PubMed ID: 1998680

  • 1. Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins.
    Odake S, Kam CM, Narasimhan L, Poe M, Blake JT, Krahenbuhl O, Tschopp J, Powers JC.
    Biochemistry; 1991 Feb 26; 30(8):2217-27. PubMed ID: 1998680
    [Abstract] [Full Text] [Related]

  • 2. Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.
    Poe M, Blake JT, Boulton DA, Gammon M, Sigal NH, Wu JK, Zweerink HJ.
    J Biol Chem; 1991 Jan 05; 266(1):98-103. PubMed ID: 1985927
    [Abstract] [Full Text] [Related]

  • 3. The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes.
    Edwards KM, Kam CM, Powers JC, Trapani JA.
    J Biol Chem; 1999 Oct 22; 274(43):30468-73. PubMed ID: 10521426
    [Abstract] [Full Text] [Related]

  • 4. Substrate and inhibitor studies on proteinase 3.
    Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC.
    FEBS Lett; 1992 Feb 03; 297(1-2):119-23. PubMed ID: 1551417
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and evaluation of diphenyl phosphonate esters as inhibitors of the trypsin-like granzymes A and K and mast cell tryptase.
    Jackson DS, Fraser SA, Ni LM, Kam CM, Winkler U, Johnson DA, Froelich CJ, Hudig D, Powers JC.
    J Med Chem; 1998 Jun 18; 41(13):2289-301. PubMed ID: 9632362
    [Abstract] [Full Text] [Related]

  • 6. Granzymes (lymphocyte serine proteases): characterization with natural and synthetic substrates and inhibitors.
    Kam CM, Hudig D, Powers JC.
    Biochim Biophys Acta; 2000 Mar 07; 1477(1-2):307-23. PubMed ID: 10708866
    [Abstract] [Full Text] [Related]

  • 7. The function of lymphocyte proteases. Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors.
    Hudig D, Allison NJ, Pickett TM, Winkler U, Kam CM, Powers JC.
    J Immunol; 1991 Aug 15; 147(4):1360-8. PubMed ID: 1869829
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of CPP32-like proteases prevents granzyme B- and Fas-, but not granzyme A-based cytotoxicity exerted by CTL clones.
    Anel A, Gamen S, Alava MA, Schmitt-Verhulst AM, Piñeiro A, Naval J.
    J Immunol; 1997 Mar 01; 158(5):1999-2006. PubMed ID: 9036942
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and kinetic studies of diphenyl 1-(N-peptidylamino)alkanephosphonate esters and their biotinylated derivatives as inhibitors of serine proteases and probes for lymphocyte granzymes.
    Abuelyaman AS, Jackson DS, Hudig D, Woodard SL, Powers JC.
    Arch Biochem Biophys; 1997 Aug 15; 344(2):271-80. PubMed ID: 9264539
    [Abstract] [Full Text] [Related]

  • 10. Mammalian tissue trypsin-like enzymes: substrate specificity and inhibitory potency of substituted isocoumarin mechanism-based inhibitors, benzamidine derivatives, and arginine fluoroalkyl ketone transition-state inhibitors.
    Kam CM, Hernandez MA, Patil GS, Ueda T, Simmons WH, Braganza VJ, Powers JC.
    Arch Biochem Biophys; 1995 Feb 01; 316(2):808-14. PubMed ID: 7864637
    [Abstract] [Full Text] [Related]

  • 11. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
    Froelich CJ, Zhang X, Turbov J, Hudig D, Winkler U, Hanna WL.
    J Immunol; 1993 Dec 15; 151(12):7161-71. PubMed ID: 8258716
    [Abstract] [Full Text] [Related]

  • 12. Human complement proteins D, C2, and B. Active site mapping with peptide thioester substrates.
    Kam CM, McRae BJ, Harper JW, Niemann MA, Volanakis JE, Powers JC.
    J Biol Chem; 1987 Mar 15; 262(8):3444-51. PubMed ID: 3546307
    [Abstract] [Full Text] [Related]

  • 13. The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175.
    Poe M, Wu JK, Blake JT, Zweerink HJ, Sigal NH.
    Arch Biochem Biophys; 1991 Jan 15; 284(1):215-8. PubMed ID: 1989498
    [Abstract] [Full Text] [Related]

  • 14. Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates.
    Rukamp BJ, Kam CM, Natarajan S, Bolton BW, Smyth MJ, Kelly JM, Powers JC.
    Arch Biochem Biophys; 2004 Feb 01; 422(1):9-22. PubMed ID: 14725853
    [Abstract] [Full Text] [Related]

  • 15. Substituted isocoumarins as inhibitors of complement serine proteases.
    Kam CM, Oglesby TJ, Pangburn MK, Volanakis JE, Powers JC.
    J Immunol; 1992 Jul 01; 149(1):163-8. PubMed ID: 1607651
    [Abstract] [Full Text] [Related]

  • 16. Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes).
    Winkler U, Allison NJ, Woodard SL, Gault RA, Ewoldt GR, Kam CM, Abuelyaman A, Powers JC, Hudig D.
    Mol Immunol; 1996 Jul 01; 33(7-8):615-23. PubMed ID: 8760273
    [Abstract] [Full Text] [Related]

  • 17. Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
    Harper JW, Cook RR, Roberts CJ, McLaughlin BJ, Powers JC.
    Biochemistry; 1984 Jun 19; 23(13):2995-3002. PubMed ID: 6380580
    [Abstract] [Full Text] [Related]

  • 18. A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl.
    Hagn M, Sutton VR, Trapani JA.
    J Vis Exp; 2014 Nov 28; (93):e52419. PubMed ID: 25489668
    [Abstract] [Full Text] [Related]

  • 19. Lymphocyte granule-mediated cytolysis requires serine protease activity.
    Hudig D, Gregg NJ, Kam CM, Powers JC.
    Biochem Biophys Res Commun; 1987 Dec 31; 149(3):882-8. PubMed ID: 3480709
    [Abstract] [Full Text] [Related]

  • 20. Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I.
    Smyth MJ, McGuire MJ, Thia KY.
    J Immunol; 1995 Jun 15; 154(12):6299-305. PubMed ID: 7759868
    [Abstract] [Full Text] [Related]

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