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PUBMED FOR HANDHELDS

Journal Abstract Search

159 related items for PubMed ID: 20000469

  • 1. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
    Morwick T, Büttner FH, Cywin CL, Dahmann G, Hickey E, Jakes S, Kaplita P, Kashem MA, Kerr S, Kugler S, Mao W, Marshall D, Paw Z, Shih CK, Wu F, Young E.
    J Med Chem; 2010 Jan 28; 53(2):759-77. PubMed ID: 20000469
    [Abstract] [Full Text] [Related]

  • 2. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.
    Bosanac T, Hickey ER, Ginn J, Kashem M, Kerr S, Kugler S, Li X, Olague A, Schlyer S, Young ER.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3746-9. PubMed ID: 20471253
    [Abstract] [Full Text] [Related]

  • 3. Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account.
    Wu F, Büttner FH, Chen R, Hickey E, Jakes S, Kaplita P, Kashem MA, Kerr S, Kugler S, Paw Z, Prokopowicz A, Shih CK, Snow R, Young E, Cywin CL.
    Bioorg Med Chem Lett; 2010 Jun 01; 20(11):3235-9. PubMed ID: 20462760
    [Abstract] [Full Text] [Related]

  • 4. Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
    Yin Y, Lin L, Ruiz C, Cameron MD, Pocas J, Grant W, Schröter T, Chen W, Duckett D, Schürer S, Lograsso P, Feng Y.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6686-90. PubMed ID: 19837589
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors.
    Fang X, Chen YT, Sessions EH, Chowdhury S, Vojkovsky T, Yin Y, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, LoGrasso P, Bannister TD, Feng Y.
    Bioorg Med Chem Lett; 2011 Mar 15; 21(6):1844-8. PubMed ID: 21349713
    [Abstract] [Full Text] [Related]

  • 6. Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model.
    Ho KK, Beasley JR, Belanger L, Black D, Chan JH, Dunn D, Hu B, Klon A, Kultgen SG, Ohlmeyer M, Parlato SM, Ray PC, Pham Q, Rong Y, Roughton AL, Walker TL, Wright J, Xu K, Xu Y, Zhang L, Webb M.
    Bioorg Med Chem Lett; 2009 Nov 01; 19(21):6027-31. PubMed ID: 19800787
    [Abstract] [Full Text] [Related]

  • 7. High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.
    Andrews PD, Becroft M, Aspegren A, Gilmour J, James MJ, McRae S, Kime R, Allcock RW, Abraham A, Jiang Z, Strehl R, Mountford JC, Milligan G, Houslay MD, Adams DR, Frearson JA.
    Biochem J; 2010 Nov 15; 432(1):21-33. PubMed ID: 20854259
    [Abstract] [Full Text] [Related]

  • 8. The development of benzimidazoles as selective rho kinase inhibitors.
    Sessions EH, Smolinski M, Wang B, Frackowiak B, Chowdhury S, Yin Y, Chen YT, Ruiz C, Lin L, Pocas J, Schröter T, Cameron MD, LoGrasso P, Feng Y, Bannister TD.
    Bioorg Med Chem Lett; 2010 Mar 15; 20(6):1939-43. PubMed ID: 20167489
    [Abstract] [Full Text] [Related]

  • 9. Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors.
    Gong LL, Fang LH, Peng JH, Liu AL, Du GH.
    J Biotechnol; 2010 Feb 01; 145(3):295-303. PubMed ID: 19963024
    [Abstract] [Full Text] [Related]

  • 10. Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors.
    Fang X, Yin Y, Chen YT, Yao L, Wang B, Cameron MD, Lin L, Khan S, Ruiz C, Schröter T, Grant W, Weiser A, Pocas J, Pachori A, Schürer S, Lograsso P, Feng Y.
    J Med Chem; 2010 Aug 12; 53(15):5727-37. PubMed ID: 20684608
    [Abstract] [Full Text] [Related]

  • 11. Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
    Ray P, Wright J, Adam J, Bennett J, Boucharens S, Black D, Cook A, Brown AR, Epemolu O, Fletcher D, Haunso A, Huggett M, Jones P, Laats S, Lyons A, Mestres J, de Man J, Morphy R, Rankovic Z, Sherborne B, Sherry L, van Straten N, Westwood P, Zaman GZ.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):97-101. PubMed ID: 21145740
    [Abstract] [Full Text] [Related]

  • 12. Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.
    Schirok H, Kast R, Figueroa-Pérez S, Bennabi S, Gnoth MJ, Feurer A, Heckroth H, Thutewohl M, Paulsen H, Knorr A, Hütter J, Lobell M, Münter K, Geiss V, Ehmke H, Lang D, Radtke M, Mittendorf J, Stasch JP.
    ChemMedChem; 2008 Dec 01; 3(12):1893-904. PubMed ID: 18973168
    [Abstract] [Full Text] [Related]

  • 13. Design and synthesis of Rho kinase inhibitors (II).
    Iwakubo M, Takami A, Okada Y, Kawata T, Tagami Y, Ohashi H, Sato M, Sugiyama T, Fukushima K, Iijima H.
    Bioorg Med Chem; 2007 Jan 01; 15(1):350-64. PubMed ID: 17046269
    [Abstract] [Full Text] [Related]

  • 14. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 2, optimization for blood pressure reduction in spontaneously hypertensive rats.
    Ginn JD, Bosanac T, Chen R, Cywin C, Hickey E, Kashem M, Kerr S, Kugler S, Li X, Prokopowicz A, Schlyer S, Smith JD, Turner MR, Wu F, Young ER.
    Bioorg Med Chem Lett; 2010 Sep 01; 20(17):5153-6. PubMed ID: 20678931
    [Abstract] [Full Text] [Related]

  • 15. Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors.
    Snow RJ, Abeywardane A, Campbell S, Lord J, Kashem MA, Khine HH, King J, Kowalski JA, Pullen SS, Roma T, Roth GP, Sarko CR, Wilson NS, Winters MP, Wolak JP, Cywin CL.
    Bioorg Med Chem Lett; 2007 Jul 01; 17(13):3660-5. PubMed ID: 17499505
    [Abstract] [Full Text] [Related]

  • 16. 4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.
    Bandarage U, Hare B, Parsons J, Pham L, Marhefka C, Bemis G, Tang Q, Moody CS, Rodems S, Shah S, Adams C, Bravo J, Charonnet E, Savic V, Come JH, Green J.
    Bioorg Med Chem Lett; 2009 Sep 01; 19(17):5191-4. PubMed ID: 19632115
    [Abstract] [Full Text] [Related]

  • 17. High-throughput biochemical kinase selectivity assays: panel development and screening applications.
    Card A, Caldwell C, Min H, Lokchander B, Hualin Xi, Sciabola S, Kamath AV, Clugston SL, Tschantz WR, Leyu Wang, Moshinsky DJ.
    J Biomol Screen; 2009 Jan 01; 14(1):31-42. PubMed ID: 19073965
    [Abstract] [Full Text] [Related]

  • 18. Detection of myosin light chain phosphorylation--a cell-based assay for screening Rho-kinase inhibitors.
    Schröter T, Griffin E, Weiser A, Feng Y, LoGrasso P.
    Biochem Biophys Res Commun; 2008 Sep 19; 374(2):356-60. PubMed ID: 18638453
    [Abstract] [Full Text] [Related]

  • 19. Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.
    Nishiguchi GA, Atallah G, Bellamacina C, Burger MT, Ding Y, Feucht PH, Garcia PD, Han W, Klivansky L, Lindvall M.
    Bioorg Med Chem Lett; 2011 Nov 01; 21(21):6366-9. PubMed ID: 21945284
    [Abstract] [Full Text] [Related]

  • 20. Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).
    Christopher JA, Bamborough P, Alder C, Campbell A, Cutler GJ, Down K, Hamadi AM, Jolly AM, Kerns JK, Lucas FS, Mellor GW, Miller DD, Morse MA, Pancholi KD, Rumsey W, Solanke YE, Williamson R.
    J Med Chem; 2009 May 14; 52(9):3098-102. PubMed ID: 19348415
    [Abstract] [Full Text] [Related]

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