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341 related items for PubMed ID: 20008772

  • 1. Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.
    Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Feb; 54(2):890-7. PubMed ID: 20008772
    [Abstract] [Full Text] [Related]

  • 2. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 3. Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
    Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Jul 09; 54(7):2867-77. PubMed ID: 20421396
    [Abstract] [Full Text] [Related]

  • 4. Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.
    Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.
    Antimicrob Agents Chemother; 2011 Jul 09; 55(7):3465-75. PubMed ID: 21555770
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of OXA-1 beta-lactamase by penems.
    Bethel CR, Distler AM, Ruszczycky MW, Carey MP, Carey PR, Hujer AM, Taracila M, Helfand MS, Thomson JM, Kalp M, Anderson VE, Leonard DA, Hujer KM, Abe T, Venkatesan AM, Mansour TS, Bonomo RA.
    Antimicrob Agents Chemother; 2008 Sep 09; 52(9):3135-43. PubMed ID: 18559643
    [Abstract] [Full Text] [Related]

  • 6. Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors.
    Therrien C, Kotra LP, Sanschagrin F, Mobashery S, Levesque RC.
    FEBS Lett; 2000 Mar 31; 470(3):285-92. PubMed ID: 10745083
    [Abstract] [Full Text] [Related]

  • 7. Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.
    Lin S, Thomas M, Shlaes DM, Rudin SD, Knox JR, Anderson V, Bonomo RA.
    Biochem J; 1998 Jul 15; 333 ( Pt 2)(Pt 2):395-400. PubMed ID: 9735103
    [Abstract] [Full Text] [Related]

  • 8. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.
    Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA.
    Antimicrob Agents Chemother; 2012 Aug 15; 56(8):4428-38. PubMed ID: 22687511
    [Abstract] [Full Text] [Related]

  • 9. Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors.
    Helfand MS, Taracila MA, Totir MA, Bonomo RA, Buynak JD, van den Akker F, Carey PR.
    Biochemistry; 2007 Jul 24; 46(29):8689-99. PubMed ID: 17595114
    [Abstract] [Full Text] [Related]

  • 10. Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
    Ke W, Bethel CR, Papp-Wallace KM, Pagadala SR, Nottingham M, Fernandez D, Buynak JD, Bonomo RA, van den Akker F.
    Antimicrob Agents Chemother; 2012 May 24; 56(5):2713-8. PubMed ID: 22330909
    [Abstract] [Full Text] [Related]

  • 11. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
    Li M, Conklin BC, Taracila MA, Hutton RA, Skalweit MJ.
    Antimicrob Agents Chemother; 2012 Nov 24; 56(11):5678-86. PubMed ID: 22908166
    [Abstract] [Full Text] [Related]

  • 12. Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography.
    Helfand MS, Totir MA, Carey MP, Hujer AM, Bonomo RA, Carey PR.
    Biochemistry; 2003 Nov 25; 42(46):13386-92. PubMed ID: 14621983
    [Abstract] [Full Text] [Related]

  • 13. Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence.
    Kalp M, Totir MA, Buynak JD, Carey PR.
    J Am Chem Soc; 2009 Feb 18; 131(6):2338-47. PubMed ID: 19161282
    [Abstract] [Full Text] [Related]

  • 14. Elucidating the role of Trp105 in the KPC-2 β-lactamase.
    Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA.
    Protein Sci; 2010 Sep 18; 19(9):1714-27. PubMed ID: 20662006
    [Abstract] [Full Text] [Related]

  • 15. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 16. Clinical inhibitor-resistant mutants of the beta-lactamase TEM-1 at amino-acid position 69. Kinetic analysis and molecular modelling.
    Chaibi EB, Péduzzi J, Farzaneh S, Barthélémy M, Sirot D, Labia R.
    Biochim Biophys Acta; 1998 Jan 15; 1382(1):38-46. PubMed ID: 9507060
    [Abstract] [Full Text] [Related]

  • 17. Why tazobactam and sulbactam have different intermediates population with SHV-1 β-lactamase: a molecular dynamics study.
    Li R, Wang YT, Chen CL.
    J Mol Model; 2013 Jun 15; 19(6):2519-24. PubMed ID: 23455927
    [Abstract] [Full Text] [Related]

  • 18. Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.
    Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA.
    mBio; 2017 Oct 31; 8(5):. PubMed ID: 29089425
    [Abstract] [Full Text] [Related]

  • 19. Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.
    Papp-Wallace KM, Winkler ML, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 31; 59(7):3710-7. PubMed ID: 25666153
    [Abstract] [Full Text] [Related]

  • 20. A kinetic study of NMC-A beta-lactamase, an Ambler class A carbapenemase also hydrolyzing cephamycins.
    Mariotte-Boyer S, Nicolas-Chanoine MH, Labia R.
    FEMS Microbiol Lett; 1996 Sep 15; 143(1):29-33. PubMed ID: 8807798
    [Abstract] [Full Text] [Related]

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