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367 related items for PubMed ID: 20054829

  • 1. Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
    Cade CE, Dlouhy AC, Medzihradszky KF, Salas-Castillo SP, Ghiladi RA.
    Protein Sci; 2010 Mar; 19(3):458-74. PubMed ID: 20054829
    [Abstract] [Full Text] [Related]

  • 2. Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
    Brossier F, Boudinet M, Jarlier V, Petrella S, Sougakoff W.
    Tuberculosis (Edinb); 2016 Sep; 100():15-24. PubMed ID: 27553406
    [Abstract] [Full Text] [Related]

  • 3. Antibiotic resistance in Mycobacterium tuberculosis: peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG).
    Suarez J, Ranguelova K, Schelvis JPM, Magliozzo RS.
    J Biol Chem; 2009 Jun 12; 284(24):16146-16155. PubMed ID: 19363028
    [Abstract] [Full Text] [Related]

  • 4. Mutation of katG in a clinical isolate of Mycobacterium tuberculosis: effects on catalase-peroxidase for isoniazid activation.
    Purkan, Ihsanawati, Natalia D, Syah YM, Retnoningrum DS, Kusuma HS.
    Ukr Biochem J; 2016 Jun 12; 88(5):71-81. PubMed ID: 29235814
    [Abstract] [Full Text] [Related]

  • 5. Analysis of interactions of clinical mutants of catalase-peroxidase (KatG) responsible for isoniazid resistance in Mycobacterium tuberculosis with derivatives of isoniazid.
    Unissa AN, Doss C GP, Kumar T, Swathi S, Lakshmi AR, Hanna LE.
    J Glob Antimicrob Resist; 2017 Dec 12; 11():57-67. PubMed ID: 28743650
    [Abstract] [Full Text] [Related]

  • 6. Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
    Zhao X, Yu H, Yu S, Wang F, Sacchettini JC, Magliozzo RS.
    Biochemistry; 2006 Apr 04; 45(13):4131-40. PubMed ID: 16566587
    [Abstract] [Full Text] [Related]

  • 7. Significance of catalase-peroxidase (KatG) mutations in mediating isoniazid resistance in clinical strains of Mycobacterium tuberculosis.
    Unissa AN, Doss C GP, Kumar T, Sukumar S, Lakshmi AR, Hanna LE.
    J Glob Antimicrob Resist; 2018 Dec 04; 15():111-120. PubMed ID: 29990547
    [Abstract] [Full Text] [Related]

  • 8. Reduced affinity for Isoniazid in the S315T mutant of Mycobacterium tuberculosis KatG is a key factor in antibiotic resistance.
    Yu S, Girotto S, Lee C, Magliozzo RS.
    J Biol Chem; 2003 Apr 25; 278(17):14769-75. PubMed ID: 12586821
    [Abstract] [Full Text] [Related]

  • 9. Three-dimensional model and molecular mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid-resistant KatG mutants.
    Mo L, Zhang W, Wang J, Weng XH, Chen S, Shao LY, Pang MY, Chen ZW.
    Microb Drug Resist; 2004 Apr 25; 10(4):269-79. PubMed ID: 15650370
    [Abstract] [Full Text] [Related]

  • 10. The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance.
    Rawat R, Whitty A, Tonge PJ.
    Proc Natl Acad Sci U S A; 2003 Nov 25; 100(24):13881-6. PubMed ID: 14623976
    [Abstract] [Full Text] [Related]

  • 11. Molecular Analysis of katG Encoding Catalase-Peroxidase from Clinical Isolate of Isoniazid-Resistant Mycobacterium tuberculosis.
    Purkan P, Ihsanawati I, Natalia D, Syah YM, Retnoningrum DS, Siswanto I.
    J Med Life; 2018 Nov 25; 11(2):160-167. PubMed ID: 30140323
    [Abstract] [Full Text] [Related]

  • 12. Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.
    Ando H, Kondo Y, Suetake T, Toyota E, Kato S, Mori T, Kirikae T.
    Antimicrob Agents Chemother; 2010 May 25; 54(5):1793-9. PubMed ID: 20211896
    [Abstract] [Full Text] [Related]

  • 13. Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG.
    Ghiladi RA, Medzihradszky KF, Rusnak FM, Ortiz de Montellano PR.
    J Am Chem Soc; 2005 Sep 28; 127(38):13428-42. PubMed ID: 16173777
    [Abstract] [Full Text] [Related]

  • 14. The mutations of katG and inhA genes of isoniazid-resistant Mycobacterium tuberculosis isolates in Taiwan.
    Tseng ST, Tai CH, Li CR, Lin CF, Shi ZY.
    J Microbiol Immunol Infect; 2015 Jun 28; 48(3):249-55. PubMed ID: 24184004
    [Abstract] [Full Text] [Related]

  • 15. Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug.
    Reingewertz TH, Meyer T, McIntosh F, Sullivan J, Meir M, Chang YF, Behr MA, Barkan D.
    Antimicrob Agents Chemother; 2020 Jan 27; 64(2):. PubMed ID: 31767723
    [Abstract] [Full Text] [Related]

  • 16. Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.
    Marney MW, Metzger RP, Hecht D, Valafar F.
    Tuberculosis (Edinb); 2018 Jan 27; 108():155-162. PubMed ID: 29523317
    [Abstract] [Full Text] [Related]

  • 17. Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.
    Ando H, Kitao T, Miyoshi-Akiyama T, Kato S, Mori T, Kirikae T.
    Mol Microbiol; 2011 Mar 27; 79(6):1615-28. PubMed ID: 21244531
    [Abstract] [Full Text] [Related]

  • 18. Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: effects on catalase-peroxidase activities and isoniazid resistance.
    Rouse DA, DeVito JA, Li Z, Byer H, Morris SL.
    Mol Microbiol; 1996 Nov 27; 22(3):583-92. PubMed ID: 8939440
    [Abstract] [Full Text] [Related]

  • 19. Insights on the Mechanism of Action of INH-C10 as an Antitubercular Prodrug.
    Vila-Viçosa D, Victor BL, Ramos J, Machado D, Viveiros M, Switala J, Loewen PC, Leitão R, Martins F, Machuqueiro M.
    Mol Pharm; 2017 Dec 04; 14(12):4597-4605. PubMed ID: 29091448
    [Abstract] [Full Text] [Related]

  • 20. Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis.
    Harrison GA, Wang ER, Cho K, Mreyoud Y, Sarkar S, Almqvist F, Patti GJ, Stallings CL.
    mBio; 2024 Mar 13; 15(3):e0296823. PubMed ID: 38294237
    [Abstract] [Full Text] [Related]

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