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Journal Abstract Search

387 related items for PubMed ID: 20071453

  • 1. Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.
    Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S.
    Drug Metab Dispos; 2010 Apr; 38(4):600-5. PubMed ID: 20071453
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  • 3. Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates.
    Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ.
    Drug Metab Dispos; 2007 Jan; 35(1):86-94. PubMed ID: 17050651
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  • 6. FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys.
    Datta-Mannan A, Chow CK, Dickinson C, Driver D, Lu J, Witcher DR, Wroblewski VJ.
    Drug Metab Dispos; 2012 Aug; 40(8):1545-55. PubMed ID: 22584253
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  • 7. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.
    Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC.
    Int Immunol; 2006 Dec; 18(12):1759-69. PubMed ID: 17077181
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  • 8. Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.
    Suzuki T, Ishii-Watabe A, Tada M, Kobayashi T, Kanayasu-Toyoda T, Kawanishi T, Yamaguchi T.
    J Immunol; 2010 Feb 15; 184(4):1968-76. PubMed ID: 20083659
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  • 9. Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor.
    Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Wroblewski VJ.
    J Biol Chem; 2007 Jan 19; 282(3):1709-17. PubMed ID: 17135257
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  • 11. Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?
    Gurbaxani B, Dostalek M, Gardner I.
    Mol Immunol; 2013 Dec 19; 56(4):660-74. PubMed ID: 23917469
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  • 12. A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies.
    Stracke J, Emrich T, Rueger P, Schlothauer T, Kling L, Knaupp A, Hertenberger H, Wolfert A, Spick C, Lau W, Drabner G, Reiff U, Koll H, Papadimitriou A.
    MAbs; 2014 Dec 19; 6(5):1229-42. PubMed ID: 25517308
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  • 15. Identification of IgG(1) variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: comparison of soluble receptor-based and cell-based binding assays.
    Lu Y, Vernes JM, Chiang N, Ou Q, Ding J, Adams C, Hong K, Truong BT, Ng D, Shen A, Nakamura G, Gong Q, Presta LG, Beresini M, Kelley B, Lowman H, Wong WL, Meng YG.
    J Immunol Methods; 2011 Feb 28; 365(1-2):132-41. PubMed ID: 21185301
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  • 18. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
    Abdiche YN, Yeung YA, Chaparro-Riggers J, Barman I, Strop P, Chin SM, Pham A, Bolton G, McDonough D, Lindquist K, Pons J, Rajpal A.
    MAbs; 2015 Feb 28; 7(2):331-43. PubMed ID: 25658443
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  • 19. The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.
    Andersen JT, Dee Qian J, Sandlie I.
    Eur J Immunol; 2006 Nov 28; 36(11):3044-51. PubMed ID: 17048273
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  • 20. A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life.
    Yeung YA, Wu X, Reyes AE, Vernes JM, Lien S, Lowe J, Maia M, Forrest WF, Meng YG, Damico LA, Ferrara N, Lowman HB.
    Cancer Res; 2010 Apr 15; 70(8):3269-77. PubMed ID: 20354184
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