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189 related items for PubMed ID: 2009090

  • 1. The killing of cultured hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI) as a model of the cytotoxicity of acetaminophen.
    Harman AW, Kyle ME, Serroni A, Farber JL.
    Biochem Pharmacol; 1991 Apr 15; 41(8):1111-7. PubMed ID: 2009090
    [Abstract] [Full Text] [Related]

  • 2. Mechanisms of N-acetyl-p-benzoquinone imine cytotoxicity.
    Albano E, Rundgren M, Harvison PJ, Nelson SD, Moldéus P.
    Mol Pharmacol; 1985 Sep 15; 28(3):306-11. PubMed ID: 4033631
    [Abstract] [Full Text] [Related]

  • 3. Comparative cytotoxic effects of N-acetyl-p-benzoquinone imine and two dimethylated analogues.
    Rundgren M, Porubek DJ, Harvison PJ, Cotgreave IA, Moldéus P, Nelson SD.
    Mol Pharmacol; 1988 Oct 15; 34(4):566-72. PubMed ID: 3173335
    [Abstract] [Full Text] [Related]

  • 4. The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
    van de Straat R, de Vries J, Debets AJ, Vermeulen NP.
    Biochem Pharmacol; 1987 Jul 01; 36(13):2065-70. PubMed ID: 3606627
    [Abstract] [Full Text] [Related]

  • 5. 1,3-(2-Chloroethyl)-1-nitrosourea potentiates the toxicity of acetaminophen both in the phenobarbital-induced rat and in hepatocytes cultured from such animals.
    Kyle ME, Nakae D, Serroni A, Farber JL.
    Mol Pharmacol; 1988 Oct 01; 34(4):584-9. PubMed ID: 3173337
    [Abstract] [Full Text] [Related]

  • 6. The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.
    Moore M, Thor H, Moore G, Nelson S, Moldéus P, Orrenius S.
    J Biol Chem; 1985 Oct 25; 260(24):13035-40. PubMed ID: 2932433
    [Abstract] [Full Text] [Related]

  • 7. The acetaminophen metabolite N-acetyl-p-benzoquinone imine (NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5-oxoprolinuric acidosis?
    Walker V, Mills GA, Anderson ME, Ingle BL, Jackson JM, Moss CL, Sharrod-Cole H, Skipp PJ.
    Xenobiotica; 2017 Feb 25; 47(2):164-175. PubMed ID: 27086508
    [Abstract] [Full Text] [Related]

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  • 9. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen.
    Kyle ME, Miccadei S, Nakae D, Farber JL.
    Biochem Biophys Res Commun; 1987 Dec 31; 149(3):889-96. PubMed ID: 3122747
    [Abstract] [Full Text] [Related]

  • 10. Role of iron and glutathione redox cycle in acetaminophen-induced cytotoxicity to cultured rat hepatocytes.
    Ito Y, Suzuki Y, Ogonuki H, Hiraishi H, Razandi M, Terano A, Harada T, Ivey KJ.
    Dig Dis Sci; 1994 Jun 31; 39(6):1257-64. PubMed ID: 8200258
    [Abstract] [Full Text] [Related]

  • 11. Potentiation in the intact rat of the hepatotoxicity of acetaminophen by 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Nakae D, Oakes JW, Farber JL.
    Arch Biochem Biophys; 1988 Dec 31; 267(2):651-9. PubMed ID: 3214175
    [Abstract] [Full Text] [Related]

  • 12. N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes.
    Andersson BS, Rundgren M, Nelson SD, Harder S.
    Chem Biol Interact; 1990 Dec 31; 75(2):201-11. PubMed ID: 2369786
    [Abstract] [Full Text] [Related]

  • 13. Killing of cultured hepatocytes by the mixed-function oxidation of ethoxycoumarin.
    Gerson RJ, Serroni A, Gilfor D, Ellen JM, Farber JL.
    Biochem Pharmacol; 1986 Dec 01; 35(23):4311-9. PubMed ID: 3790155
    [Abstract] [Full Text] [Related]

  • 14. The metabolism of N-acetyl-3,5-dimethyl-p-benzoquinone imine in isolated hepatocytes involves N-deacetylation.
    Rossi L, McGirr LG, Silva J, O'Brien PJ.
    Mol Pharmacol; 1988 Nov 01; 34(5):674-81. PubMed ID: 3193958
    [Abstract] [Full Text] [Related]

  • 15. N-acetyl-p-benzoquinone imine-induced protein thiol modification in isolated rat hepatocytes.
    Weis M, Morgenstern R, Cotgreave IA, Nelson SD, Moldéus P.
    Biochem Pharmacol; 1992 Apr 01; 43(7):1493-505. PubMed ID: 1567474
    [Abstract] [Full Text] [Related]

  • 16. Oxidative stress in cultured hepatocytes exposed to acetaminophen.
    Adamson GM, Harman AW.
    Biochem Pharmacol; 1993 Jun 09; 45(11):2289-94. PubMed ID: 8517869
    [Abstract] [Full Text] [Related]

  • 17. Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol.
    Holme JA, Dahlin DC, Nelson SD, Dybing E.
    Biochem Pharmacol; 1984 Feb 01; 33(3):401-6. PubMed ID: 6704159
    [Abstract] [Full Text] [Related]

  • 18. Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes.
    Li QJ, Bessems JG, Commandeur JN, Adams B, Vermeulen NP.
    Biochem Pharmacol; 1994 Oct 18; 48(8):1631-40. PubMed ID: 7980628
    [Abstract] [Full Text] [Related]

  • 19. Molecular mechanism for prevention of N-acetyl-p-benzoquinoneimine cytotoxicity by the permeable thiol drugs diethyldithiocarbamate and dithiothreitol.
    Lauriault VV, O'Brien PJ.
    Mol Pharmacol; 1991 Jul 18; 40(1):125-34. PubMed ID: 1649964
    [Abstract] [Full Text] [Related]

  • 20. Peroxidation-dependent and peroxidation-independent mechanisms by which acetaminophen kills cultured rat hepatocytes.
    Farber JL, Leonard TB, Kyle ME, Nakae D, Serroni A, Rogers SA.
    Arch Biochem Biophys; 1988 Dec 18; 267(2):640-50. PubMed ID: 3214174
    [Abstract] [Full Text] [Related]

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