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Journal Abstract Search

74 related items for PubMed ID: 20124700

  • 1. Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.
    Dhagat U, Endo S, Mamiya H, Hara A, El-Kabbani O.
    Acta Crystallogr D Biol Crystallogr; 2010 Feb; 66(Pt 2):198-204. PubMed ID: 20124700
    [Abstract] [Full Text] [Related]

  • 2. Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.
    Dhagat U, Endo S, Mamiya H, Hara A, El-Kabbani O.
    Acta Crystallogr D Biol Crystallogr; 2009 Mar; 65(Pt 3):257-65. PubMed ID: 19237748
    [Abstract] [Full Text] [Related]

  • 3. Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.
    Faucher F, Cantin L, Pereira de Jésus-Tran K, Lemieux M, Luu-The V, Labrie F, Breton R.
    J Mol Biol; 2007 Jun 01; 369(2):525-40. PubMed ID: 17442338
    [Abstract] [Full Text] [Related]

  • 4. Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.
    Faucher F, Pereira de Jésus-Tran K, Cantin L, Luu-The V, Labrie F, Breton R.
    J Mol Biol; 2006 Dec 08; 364(4):747-63. PubMed ID: 17034817
    [Abstract] [Full Text] [Related]

  • 5. Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency.
    Svensson S, Höög JO, Schneider G, Sandalova T.
    J Mol Biol; 2000 Sep 15; 302(2):441-53. PubMed ID: 10970744
    [Abstract] [Full Text] [Related]

  • 6. Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition.
    Faucher F, Cantin L, Luu-The V, Labrie F, Breton R.
    Biochemistry; 2008 Dec 23; 47(51):13537-46. PubMed ID: 19075558
    [Abstract] [Full Text] [Related]

  • 7. Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.
    Cobessi D, Tête-Favier F, Marchal S, Branlant G, Aubry A.
    J Mol Biol; 2000 Jun 30; 300(1):141-52. PubMed ID: 10864505
    [Abstract] [Full Text] [Related]

  • 8. Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+.
    Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M.
    Biochemistry; 1996 Aug 20; 35(33):10702-11. PubMed ID: 8718859
    [Abstract] [Full Text] [Related]

  • 9. Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants.
    Rosano C, Bisso A, Izzo G, Tonetti M, Sturla L, De Flora A, Bolognesi M.
    J Mol Biol; 2000 Oct 13; 303(1):77-91. PubMed ID: 11021971
    [Abstract] [Full Text] [Related]

  • 10. Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.
    El-Kabbani O, Ishikura S, Darmanin C, Carbone V, Chung RP, Usami N, Hara A.
    Proteins; 2004 May 15; 55(3):724-32. PubMed ID: 15103634
    [Abstract] [Full Text] [Related]

  • 11. Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
    Dhagat U, Carbone V, Chung RP, Schulze-Briese C, Endo S, Hara A, El-Kabbani O.
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2007 Oct 01; 63(Pt 10):825-30. PubMed ID: 17909281
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.
    Dhagat U, Endo S, Hara A, El-Kabbani O.
    Bioorg Med Chem; 2008 Mar 15; 16(6):3245-54. PubMed ID: 18165015
    [Abstract] [Full Text] [Related]

  • 13. Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli.
    Tanaka N, Nonaka T, Tanabe T, Yoshimoto T, Tsuru D, Mitsui Y.
    Biochemistry; 1996 Jun 18; 35(24):7715-30. PubMed ID: 8672472
    [Abstract] [Full Text] [Related]

  • 14. Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity.
    Zhang B, Zhu DW, Hu XJ, Zhou M, Shang P, Lin SX.
    J Steroid Biochem Mol Biol; 2014 May 18; 141():135-43. PubMed ID: 24434280
    [Abstract] [Full Text] [Related]

  • 15. Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase.
    Lee P, Colman RF.
    Arch Biochem Biophys; 2002 May 01; 401(1):81-90. PubMed ID: 12054490
    [Abstract] [Full Text] [Related]

  • 16. Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.
    Heredia VV, Cooper WC, Kruger RG, Jin Y, Penning TM.
    Biochemistry; 2004 May 18; 43(19):5832-41. PubMed ID: 15134457
    [Abstract] [Full Text] [Related]

  • 17. Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.
    Endo S, Sanai M, Horie K, Matsunaga T, Ishikura S, Tajima K, El-Kabbani O, Hara A.
    Arch Biochem Biophys; 2007 Nov 01; 467(1):76-86. PubMed ID: 17888864
    [Abstract] [Full Text] [Related]

  • 18. Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.
    Jin Y, Stayrook SE, Albert RH, Palackal NT, Penning TM, Lewis M.
    Biochemistry; 2001 Aug 28; 40(34):10161-8. PubMed ID: 11513593
    [Abstract] [Full Text] [Related]

  • 19. A crystallographic comparison between mutated glyceraldehyde-3-phosphate dehydrogenases from Bacillus stearothermophilus complexed with either NAD+ or NADP+.
    Didierjean C, Rahuel-Clermont S, Vitoux B, Dideberg O, Branlant G, Aubry A.
    J Mol Biol; 1997 May 16; 268(4):739-59. PubMed ID: 9175858
    [Abstract] [Full Text] [Related]

  • 20. Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
    Lee HJ, Wang M, Paschke R, Nandy A, Ghisla S, Kim JJ.
    Biochemistry; 1996 Sep 24; 35(38):12412-20. PubMed ID: 8823176
    [Abstract] [Full Text] [Related]

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