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363 related items for PubMed ID: 20127721

  • 1. Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.
    Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH.
    J Cell Biochem; 2010 Apr 15; 109(6):1172-84. PubMed ID: 20127721
    [Abstract] [Full Text] [Related]

  • 2. PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
    Wang L, Harris TE, Roth RA, Lawrence JC.
    J Biol Chem; 2007 Jul 06; 282(27):20036-44. PubMed ID: 17510057
    [Abstract] [Full Text] [Related]

  • 3. Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.
    Wang L, Harris TE, Lawrence JC.
    J Biol Chem; 2008 Jun 06; 283(23):15619-27. PubMed ID: 18372248
    [Abstract] [Full Text] [Related]

  • 4. Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes.
    Hong-Brown LQ, Brown CR, Navaratnarajah M, Lang CH.
    Alcohol Clin Exp Res; 2013 Nov 06; 37(11):1849-61. PubMed ID: 23895284
    [Abstract] [Full Text] [Related]

  • 5. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K.
    J Biol Chem; 2007 Jul 13; 282(28):20329-39. PubMed ID: 17517883
    [Abstract] [Full Text] [Related]

  • 6. The association of AMPK with ULK1 regulates autophagy.
    Lee JW, Park S, Takahashi Y, Wang HG.
    PLoS One; 2010 Nov 03; 5(11):e15394. PubMed ID: 21072212
    [Abstract] [Full Text] [Related]

  • 7. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.
    Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jenö P, Arrieumerlou C, Hall MN.
    PLoS One; 2007 Nov 21; 2(11):e1217. PubMed ID: 18030348
    [Abstract] [Full Text] [Related]

  • 8. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.
    Shaw RJ.
    Acta Physiol (Oxf); 2009 May 21; 196(1):65-80. PubMed ID: 19245654
    [Abstract] [Full Text] [Related]

  • 9. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1.
    Zhang L, Kimball SR, Jefferson LS, Shenberger JS.
    Free Radic Biol Med; 2009 Jun 01; 46(11):1500-9. PubMed ID: 19281842
    [Abstract] [Full Text] [Related]

  • 10. The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
    Rapley J, Oshiro N, Ortiz-Vega S, Avruch J.
    J Biol Chem; 2011 Nov 04; 286(44):38043-38053. PubMed ID: 21914810
    [Abstract] [Full Text] [Related]

  • 11. A role for Raptor phosphorylation in the mechanical activation of mTOR signaling.
    Frey JW, Jacobs BL, Goodman CA, Hornberger TA.
    Cell Signal; 2014 Feb 04; 26(2):313-22. PubMed ID: 24239769
    [Abstract] [Full Text] [Related]

  • 12. Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine.
    Hong-Brown LQ, Brown CR, Kazi AA, Navaratnarajah M, Lang CH.
    Am J Physiol Cell Physiol; 2012 May 15; 302(10):C1557-65. PubMed ID: 22442136
    [Abstract] [Full Text] [Related]

  • 13. Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
    Misra UK, Pizzo SV.
    PLoS One; 2012 May 15; 7(12):e51735. PubMed ID: 23272152
    [Abstract] [Full Text] [Related]

  • 14. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding.
    Dunlop EA, Hunt DK, Acosta-Jaquez HA, Fingar DC, Tee AR.
    Autophagy; 2011 Jul 15; 7(7):737-47. PubMed ID: 21460630
    [Abstract] [Full Text] [Related]

  • 15. Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.
    Tzatsos A.
    J Biol Chem; 2009 Aug 21; 284(34):22525-34. PubMed ID: 19561084
    [Abstract] [Full Text] [Related]

  • 16. PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex.
    Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG.
    J Biol Chem; 2007 Aug 24; 282(34):24514-24. PubMed ID: 17604271
    [Abstract] [Full Text] [Related]

  • 17. Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes.
    Hong-Brown LQ, Brown CR, Huber DS, Lang CH.
    J Biol Chem; 2007 Feb 09; 282(6):3702-12. PubMed ID: 17164244
    [Abstract] [Full Text] [Related]

  • 18. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
    Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.
    Mol Cell Biol; 2011 May 09; 31(9):1870-84. PubMed ID: 21383064
    [Abstract] [Full Text] [Related]

  • 19. Curcumin disrupts the Mammalian target of rapamycin-raptor complex.
    Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S.
    Cancer Res; 2009 Feb 01; 69(3):1000-8. PubMed ID: 19176385
    [Abstract] [Full Text] [Related]

  • 20. Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts.
    Hong-Brown LQ, Brown CR, Navaratnarajah M, Huber DS, Lang CH.
    Alcohol Clin Exp Res; 2011 Aug 01; 35(8):1445-53. PubMed ID: 21438886
    [Abstract] [Full Text] [Related]

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