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202 related items for PubMed ID: 20137946

  • 1. Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.
    Eastwood P, Gonzalez J, Paredes S, Nueda A, Domenech T, Alberti J, Vidal B.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1697-700. PubMed ID: 20137946
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
    Baraldi PG, Tabrizi MA, Preti D, Bovero A, Romagnoli R, Fruttarolo F, Zaid NA, Moorman AR, Varani K, Gessi S, Merighi S, Borea PA.
    J Med Chem; 2004 Mar 11; 47(6):1434-47. PubMed ID: 14998332
    [Abstract] [Full Text] [Related]

  • 3. Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.
    Vidal B, Nueda A, Esteve C, Domenech T, Benito S, Reinoso RF, Pont M, Calbet M, López R, Cadavid MI, Loza MI, Cárdenas A, Godessart N, Beleta J, Warrellow G, Ryder H.
    J Med Chem; 2007 May 31; 50(11):2732-6. PubMed ID: 17469811
    [Abstract] [Full Text] [Related]

  • 4. 1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.
    Tabrizi MA, Baraldi PG, Preti D, Romagnoli R, Saponaro G, Baraldi S, Moorman AR, Zaid AN, Varani K, Borea PA.
    Bioorg Med Chem; 2008 Mar 01; 16(5):2419-30. PubMed ID: 18077171
    [Abstract] [Full Text] [Related]

  • 5. Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.
    Bedford ST, Benwell KR, Brooks T, Chen I, Comer M, Dugdale S, Haymes T, Jordan AM, Kennett GA, Knight AR, Klenke B, LeStrat L, Merrett A, Misra A, Lightowler S, Padfield A, Poullennec K, Reece M, Simmonite H, Wong M, Yule IA.
    Bioorg Med Chem Lett; 2009 Oct 15; 19(20):5945-9. PubMed ID: 19733067
    [Abstract] [Full Text] [Related]

  • 6. Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.
    Elzein E, Kalla R, Li X, Perry T, Parkhill E, Palle V, Varkhedkar V, Gimbel A, Zeng D, Lustig D, Leung K, Zablocki J.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):302-6. PubMed ID: 16275090
    [Abstract] [Full Text] [Related]

  • 7. Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.
    Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC.
    J Med Chem; 2004 Dec 02; 47(25):6218-29. PubMed ID: 15566292
    [Abstract] [Full Text] [Related]

  • 8. Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
    Gillespie RJ, Cliffe IA, Dawson CE, Dourish CT, Gaur S, Giles PR, Jordan AM, Knight AR, Lawrence A, Lerpiniere J, Misra A, Pratt RM, Todd RS, Upton R, Weiss SM, Williamson DS.
    Bioorg Med Chem Lett; 2008 May 01; 18(9):2920-3. PubMed ID: 18407496
    [Abstract] [Full Text] [Related]

  • 9. 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.
    Stefanachi A, Nicolotti O, Leonetti F, Cellamare S, Campagna F, Loza MI, Brea JM, Mazza F, Gavuzzo E, Carotti A.
    Bioorg Med Chem; 2008 Nov 15; 16(22):9780-9. PubMed ID: 18938084
    [Abstract] [Full Text] [Related]

  • 10. Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement.
    Eastwood P, Gonzalez J, Paredes S, Fonquerna S, Cardús A, Alonso JA, Nueda A, Domenech T, Reinoso RF, Vidal B.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1634-7. PubMed ID: 20138516
    [Abstract] [Full Text] [Related]

  • 11. Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.
    Yaziji V, Rodríguez D, Gutiérrez-de-Terán H, Coelho A, Caamaño O, García-Mera X, Brea J, Loza MI, Cadavid MI, Sotelo E.
    J Med Chem; 2011 Jan 27; 54(2):457-71. PubMed ID: 21186795
    [Abstract] [Full Text] [Related]

  • 12. Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist.
    Chen X, Pierce B, Naing W, Grapperhaus ML, Phillion DP.
    Bioorg Med Chem Lett; 2010 May 15; 20(10):3107-11. PubMed ID: 20392639
    [Abstract] [Full Text] [Related]

  • 13. Structure-affinity relationships of adenosine A2B receptor ligands.
    Beukers MW, Meurs I, Ijzerman AP.
    Med Res Rev; 2006 Sep 15; 26(5):667-98. PubMed ID: 16847822
    [Abstract] [Full Text] [Related]

  • 14. Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.
    Pastorin G, Da Ros T, Spalluto G, Deflorian F, Moro S, Cacciari B, Baraldi PG, Gessi S, Varani K, Borea PA.
    J Med Chem; 2003 Sep 25; 46(20):4287-96. PubMed ID: 13678407
    [Abstract] [Full Text] [Related]

  • 15. The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.
    Lunniss GE, Barnes AA, Barton N, Biagetti M, Bianchi F, Blowers SM, Caberlotto LL, Emmons A, Holmes IP, Montanari D, Norris R, Puckey GV, Walters DJ, Watson SP, Willis J.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7341-4. PubMed ID: 21074426
    [Abstract] [Full Text] [Related]

  • 16. A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.
    Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Brown L, Cheung R, Christie J, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Press NE, Sahri H, Tuffnell AR, Tweed M, Fozard JR.
    Bioorg Med Chem Lett; 2005 Jun 15; 15(12):3081-5. PubMed ID: 15876531
    [Abstract] [Full Text] [Related]

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  • 19. 4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists.
    Cheung AW, Brinkman J, Firooznia F, Flohr A, Grimsby J, Gubler ML, Guertin K, Hamid R, Marcopulos N, Norcross RD, Qi L, Ramsey G, Tan J, Wen Y, Sarabu R.
    Bioorg Med Chem Lett; 2010 Jul 15; 20(14):4140-6. PubMed ID: 20541935
    [Abstract] [Full Text] [Related]

  • 20. 7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.
    Sandham DA, Adcock C, Bala K, Barker L, Brown Z, Dubois G, Budd D, Cox B, Fairhurst RA, Furegati M, Leblanc C, Manini J, Profit R, Reilly J, Stringer R, Schmidt A, Turner KL, Watson SJ, Willis J, Williams G, Wilson C.
    Bioorg Med Chem Lett; 2009 Aug 15; 19(16):4794-8. PubMed ID: 19592244
    [Abstract] [Full Text] [Related]

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