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Journal Abstract Search

211 related items for PubMed ID: 2014216

  • 1. Oral absorption of peptides: influence of pH and inhibitors on the intestinal hydrolysis of leu-enkephalin and analogues.
    Friedman DI, Amidon GL.
    Pharm Res; 1991 Jan; 8(1):93-6. PubMed ID: 2014216
    [Abstract] [Full Text] [Related]

  • 2. Transdermal delivery of bioactive peptides: the effect of n-decylmethyl sulfoxide, pH, and inhibitors on enkephalin metabolism and transport.
    Choi HK, Flynn GL, Amidon GL.
    Pharm Res; 1990 Nov; 7(11):1099-106. PubMed ID: 2293206
    [Abstract] [Full Text] [Related]

  • 3. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and methods to increase absorption.
    Aungst BJ, Blake JA, Hussain MA.
    J Pharmacol Exp Ther; 1991 Oct; 259(1):139-45. PubMed ID: 1920113
    [Abstract] [Full Text] [Related]

  • 4. Effects of three peptidase inhibitors, amastatin, captopril and phosphoramidon, on the hydrolysis of [Met5]-enkephalin-Arg6-Phe7 and other opioid peptides.
    Hiranuma T, Kitamura K, Taniguchi T, Kobayashi T, Tamaki R, Kanai M, Akahori K, Iwao K, Oka T.
    Naunyn Schmiedebergs Arch Pharmacol; 1998 Mar; 357(3):276-82. PubMed ID: 9550299
    [Abstract] [Full Text] [Related]

  • 5. Identification and characterization of aminopeptidases from Aplysia californica.
    Bawab W, Querido E, Crine P, DesGroseillers L.
    Biochem J; 1992 Sep 15; 286 ( Pt 3)(Pt 3):967-75. PubMed ID: 1417757
    [Abstract] [Full Text] [Related]

  • 6. Effects of various protease inhibitors on the stability and permeability of [D-Ala2,D-Leu5]enkephalin in the rat intestine: comparison with leucine enkephalin.
    Uchiyama T, Kotani A, Kishida T, Tatsumi H, Okamoto A, Fujita T, Murakami M, Muranishi S, Yamamoto A.
    J Pharm Sci; 1998 Apr 15; 87(4):448-52. PubMed ID: 9548897
    [Abstract] [Full Text] [Related]

  • 7. Rat jejunal permeability and metabolism of mu-selective tetrapeptides in gastrointestinal fluids from humans and rats.
    Krondahl E, Orzechowski A, Ekström G, Lennernäs H.
    Pharm Res; 1997 Dec 15; 14(12):1780-5. PubMed ID: 9453068
    [Abstract] [Full Text] [Related]

  • 8. Intestinal assimilation of a tetrapeptide in the rat. Obligate function of brush border aminopeptidase.
    Smithson KW, Gray GM.
    J Clin Invest; 1977 Sep 15; 60(3):665-74. PubMed ID: 893670
    [Abstract] [Full Text] [Related]

  • 9. Effects of peptidase inhibitors on the [Met5]-enkephalin hydrolysis in ileal and striatal preparations of guinea-pig: almost complete protection of degradation by the combination of amastatin, captopril and thiorphan.
    Hiranuma T, Oka T.
    Jpn J Pharmacol; 1986 Aug 15; 41(4):437-46. PubMed ID: 3534399
    [Abstract] [Full Text] [Related]

  • 10. Hepatic inactivation of Leu-enkephalin.
    MacKinnon KL, Zuzel KA, Billington D.
    Regul Pept; 1996 Dec 03; 67(2):85-92. PubMed ID: 8958578
    [Abstract] [Full Text] [Related]

  • 11. Further characterization of the in vitro hydrolysis of [Leu]- and [Met]enkephalin in rat plasma: HPLC-ECD measurement of substrate and metabolite concentrations.
    Shibanoki S, Weinberger SB, Ishikawa K, Martinez JL.
    Regul Pept; 1991 Feb 26; 32(3):267-78. PubMed ID: 1678195
    [Abstract] [Full Text] [Related]

  • 12. Development of novel lipophilic derivatives of DADLE (leucine enkephalin analogue): intestinal permeability characateristics of DADLE derivatives in rats.
    Uchiyama T, Kotani A, Tatsumi H, Kishida T, Okamoto A, Okada N, Murakami M, Fujita T, Fujiwara Y, Kiso Y, Muranishi S, Yamamoto A.
    Pharm Res; 2000 Dec 26; 17(12):1461-7. PubMed ID: 11303954
    [Abstract] [Full Text] [Related]

  • 13. Hydrolysis of leucine enkephalin in the nasal cavity of the rat--a possible factor in the low bioavailability of nasally administered peptides.
    Hussain A, Faraj J, Aramaki Y, Truelove JE.
    Biochem Biophys Res Commun; 1985 Dec 31; 133(3):923-8. PubMed ID: 4084310
    [Abstract] [Full Text] [Related]

  • 14. Degradation of low-molecular-weight opioid peptides by vascular plasma membrane aminopeptidase M.
    Bausback HH, Ward PE.
    Biochim Biophys Acta; 1986 Jul 16; 882(3):437-44. PubMed ID: 2873842
    [Abstract] [Full Text] [Related]

  • 15. Protection against dynorphin-(1-8) hydrolysis in membrane preparations by the combination of amastatin, captopril and phosphoramidon.
    Hiranuma T, Kitamura K, Taniguchi T, Kanai M, Arai Y, Iwao K, Oka T.
    J Pharmacol Exp Ther; 1998 Aug 16; 286(2):863-9. PubMed ID: 9694943
    [Abstract] [Full Text] [Related]

  • 16. Pulmonary metabolism of exogenous enkephalins in isolated perfused rat lungs.
    Gillespie MN, Krechniak JW, Crooks PA, Altiere RJ, Olson JW.
    J Pharmacol Exp Ther; 1985 Mar 16; 232(3):675-81. PubMed ID: 2983067
    [Abstract] [Full Text] [Related]

  • 17. Metabolism of enkephalins in head membranes of the leech Theromyzon tessulatum by peptidases: isolation of an enkephalin-degrading aminopeptidase.
    Laurent V, Salzet M.
    Regul Pept; 1996 Sep 09; 65(2):123-31. PubMed ID: 8884979
    [Abstract] [Full Text] [Related]

  • 18. Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
    Matsas R, Fulcher IS, Kenny AJ, Turner AJ.
    Proc Natl Acad Sci U S A; 1983 May 09; 80(10):3111-5. PubMed ID: 6190172
    [Abstract] [Full Text] [Related]

  • 19. Transport kinetics of leucine enkephalin across Caco-2 monolayers: quantitative analysis for contribution of enzymatic and transport barrier.
    Quan YS, Fujita T, Tohara D, Tsuji M, Kohyama M, Yamamoto A.
    Life Sci; 1999 May 09; 64(14):1243-52. PubMed ID: 10210267
    [Abstract] [Full Text] [Related]

  • 20. Intestinal metabolism and absorption of cholecystokinin analogs in rats.
    Su SF, Amidon GL, Lee HJ.
    Biochem Biophys Res Commun; 2002 Apr 05; 292(3):632-8. PubMed ID: 11922613
    [Abstract] [Full Text] [Related]

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