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Journal Abstract Search

265 related items for PubMed ID: 20149658

  • 1. Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.
    Lee J, Kim H, Yu H, Chung JY, Oh CH, Yoo KH, Sim T, Hah JM.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1573-7. PubMed ID: 20149658
    [Abstract] [Full Text] [Related]

  • 2. Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
    Kim MH, Kim M, Yu H, Kim H, Yoo KH, Sim T, Hah JM.
    Bioorg Med Chem; 2011 Mar 15; 19(6):1915-23. PubMed ID: 21353571
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  • 3. 1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives: a novel type II Raf kinase inhibitors.
    Yu H, Jung Y, Kim H, Lee J, Oh CH, Yoo KH, Sim T, Hah JM.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3805-8. PubMed ID: 20466542
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of benzyl 2-(1H-imidazole-1-yl) pyrimidine analogues as selective and potent Raf inhibitors.
    Kim M, Lee J, Jung K, Kim H, Aman W, Ryu JS, Hah JM.
    Bioorg Med Chem Lett; 2014 Aug 01; 24(15):3600-4. PubMed ID: 24878193
    [Abstract] [Full Text] [Related]

  • 5. Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.
    Jung MH, Kim H, Choi WK, El-Gamal MI, Park JH, Yoo KH, Sim TB, Lee SH, Baek D, Hah JM, Cho JH, Oh CH.
    Bioorg Med Chem Lett; 2009 Dec 01; 19(23):6538-43. PubMed ID: 19857963
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  • 6. New imidazo[2,1-b]thiazole derivatives: synthesis, in vitro anticancer evaluation, and in silico studies.
    Park JH, El-Gamal MI, Lee YS, Oh CH.
    Eur J Med Chem; 2011 Dec 01; 46(12):5769-77. PubMed ID: 22033063
    [Abstract] [Full Text] [Related]

  • 7. Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR.
    Menear KA, Gomez S, Malagu K, Bailey C, Blackburn K, Cockcroft XL, Ewen S, Fundo A, Le Gall A, Hermann G, Sebastian L, Sunose M, Presnot T, Torode E, Hickson I, Martin NM, Smith GC, Pike KG.
    Bioorg Med Chem Lett; 2009 Oct 15; 19(20):5898-901. PubMed ID: 19733066
    [Abstract] [Full Text] [Related]

  • 8. New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies.
    Choi WK, El-Gamal MI, Choi HS, Baek D, Oh CH.
    Eur J Med Chem; 2011 Dec 15; 46(12):5754-62. PubMed ID: 22014559
    [Abstract] [Full Text] [Related]

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  • 11. Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2.
    Jung MH, El-Gamal MI, Abdel-Maksoud MS, Sim T, Yoo KH, Oh CH.
    Bioorg Med Chem Lett; 2012 Jul 01; 22(13):4362-7. PubMed ID: 22647720
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  • 12. Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors.
    Zhan W, Li Y, Huang W, Zhao Y, Yao Z, Yu S, Yuan S, Jiang F, Yao S, Li S.
    Bioorg Med Chem; 2012 Jul 15; 20(14):4323-9. PubMed ID: 22721924
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  • 13. Synthesis of 2,8-disubstituted imidazo[1,5-a]pyrimidines with potent antitumor activity.
    Matsumoto H, Ikeda K, Nagata N, Takayanagi H, Mizuno Y, Tanaka M, Sasaki T.
    J Med Chem; 1999 May 06; 42(9):1661-6. PubMed ID: 10229634
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and antiproliferative activity of pyrrolo[3,2-b]pyridine derivatives against melanoma.
    Kim HJ, Jung MH, Kim H, El-Gamal MI, Sim TB, Lee SH, Hong JH, Hah JM, Cho JH, Choi JH, Yoo KH, Oh CH.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):413-7. PubMed ID: 19897366
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  • 16. Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.
    Nowak P, Cole DC, Brooijmans N, Bursavich MG, Curran KJ, Ellingboe JW, Gibbons JJ, Hollander I, Hu Y, Kaplan J, Malwitz DJ, Toral-Barza L, Verheijen JC, Zask A, Zhang WG, Yu K.
    J Med Chem; 2009 Nov 26; 52(22):7081-9. PubMed ID: 19848404
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  • 18. Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
    Li Q, Woods KW, Thomas S, Zhu GD, Packard G, Fisher J, Li T, Gong J, Dinges J, Song X, Abrams J, Luo Y, Johnson EF, Shi Y, Liu X, Klinghofer V, Des Jong R, Oltersdorf T, Stoll VS, Jakob CG, Rosenberg SH, Giranda VL.
    Bioorg Med Chem Lett; 2006 Apr 01; 16(7):2000-7. PubMed ID: 16413780
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  • 19. Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships. Part 2.
    Horiuchi T, Nagata M, Kitagawa M, Akahane K, Uoto K.
    Bioorg Med Chem; 2009 Dec 01; 17(23):7850-60. PubMed ID: 19889545
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