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389 related items for PubMed ID: 20164581

  • 1. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.
    Imbimbo BP, Giardino L, Sivilia S, Giuliani A, Gusciglio M, Pietrini V, Del Giudice E, D'Arrigo A, Leon A, Villetti G, Calzà L.
    J Alzheimers Dis; 2010; 20(1):159-73. PubMed ID: 20164581
    [Abstract] [Full Text] [Related]

  • 2. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A.
    J Pharmacol Exp Ther; 2007 Dec; 323(3):822-30. PubMed ID: 17895400
    [Abstract] [Full Text] [Related]

  • 3. The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
    Balducci C, Mehdawy B, Mare L, Giuliani A, Lorenzini L, Sivilia S, Giardino L, Calzà L, Lanzillotta A, Sarnico I, Pizzi M, Usiello A, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Nisticò G, Forloni G, Nisticò R.
    J Alzheimers Dis; 2011 Dec; 24(4):799-816. PubMed ID: 21321397
    [Abstract] [Full Text] [Related]

  • 4. Lesion-induced hippocampal plasticity in transgenic Alzheimer's disease mouse models: influences of age, genotype, and estrogen.
    Kadish I, van Groen T.
    J Alzheimers Dis; 2009 Dec; 18(2):429-45. PubMed ID: 19584452
    [Abstract] [Full Text] [Related]

  • 5. Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.
    Ding Y, Qiao A, Fan GH.
    Neurobiol Dis; 2010 Aug; 39(2):156-68. PubMed ID: 20381617
    [Abstract] [Full Text] [Related]

  • 6. A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.
    Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC.
    J Alzheimers Dis; 2010 Aug; 20(1):113-26. PubMed ID: 20164597
    [Abstract] [Full Text] [Related]

  • 7. CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
    Imbimbo BP, Hutter-Paier B, Villetti G, Facchinetti F, Cenacchi V, Volta R, Lanzillotta A, Pizzi M, Windisch M.
    Br J Pharmacol; 2009 Mar; 156(6):982-93. PubMed ID: 19239474
    [Abstract] [Full Text] [Related]

  • 8. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.
    Porrini V, Lanzillotta A, Branca C, Benarese M, Parrella E, Lorenzini L, Calzà L, Flaibani R, Spano PF, Imbimbo BP, Pizzi M.
    Neuroscience; 2015 Aug 27; 302():112-20. PubMed ID: 25450955
    [Abstract] [Full Text] [Related]

  • 9. Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease.
    Grossi C, Francese S, Casini A, Rosi MC, Luccarini I, Fiorentini A, Gabbiani C, Messori L, Moneti G, Casamenti F.
    J Alzheimers Dis; 2009 Aug 27; 17(2):423-40. PubMed ID: 19363260
    [Abstract] [Full Text] [Related]

  • 10. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease.
    He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, Zhang Y, Xu H, Tempier A, Li X, Li XM.
    Neurobiol Aging; 2009 Aug 27; 30(8):1205-16. PubMed ID: 18079026
    [Abstract] [Full Text] [Related]

  • 11. Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.
    Sivilia S, Lorenzini L, Giuliani A, Gusciglio M, Fernandez M, Baldassarro VA, Mangano C, Ferraro L, Pietrini V, Baroc MF, Viscomi AR, Ottonello S, Villetti G, Imbimbo BP, Calzà L, Giardino L.
    BMC Neurosci; 2013 Apr 05; 14():44. PubMed ID: 23560952
    [Abstract] [Full Text] [Related]

  • 12. Metallothionein-I and -III expression in animal models of Alzheimer disease.
    Carrasco J, Adlard P, Cotman C, Quintana A, Penkowa M, Xu F, Van Nostrand WE, Hidalgo J.
    Neuroscience; 2006 Dec 28; 143(4):911-22. PubMed ID: 17027170
    [Abstract] [Full Text] [Related]

  • 13. The occurrence of a deficit in contextual fear extinction in adult amyloid-over-expressing TASTPM mice is independent of the strength of conditioning but can be prevented by mild novel cage stress.
    Rattray I, Scullion GA, Soulby A, Kendall DA, Pardon MC.
    Behav Brain Res; 2009 Jun 08; 200(1):83-90. PubMed ID: 19162086
    [Abstract] [Full Text] [Related]

  • 14. Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice.
    Arendash GW, Mori T, Cao C, Mamcarz M, Runfeldt M, Dickson A, Rezai-Zadeh K, Tane J, Citron BA, Lin X, Echeverria V, Potter H.
    J Alzheimers Dis; 2009 Jun 08; 17(3):661-80. PubMed ID: 19581722
    [Abstract] [Full Text] [Related]

  • 15. Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology.
    van Groen T, Miettinen P, Kadish I.
    J Alzheimers Dis; 2011 Jun 08; 24(2):301-13. PubMed ID: 21239852
    [Abstract] [Full Text] [Related]

  • 16. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
    Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF.
    Eur J Neurosci; 2006 Jan 08; 23(1):251-60. PubMed ID: 16420434
    [Abstract] [Full Text] [Related]

  • 17. CHF5074 restores visual memory ability and pre-synaptic cortical acetylcholine release in pre-plaque Tg2576 mice.
    Giuliani A, Beggiato S, Baldassarro VA, Mangano C, Giardino L, Imbimbo BP, Antonelli T, Calzà L, Ferraro L.
    J Neurochem; 2013 Mar 08; 124(5):613-20. PubMed ID: 23278303
    [Abstract] [Full Text] [Related]

  • 18. Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.
    Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, Miao J, Li Z.
    Behav Brain Res; 2011 Sep 23; 222(2):342-50. PubMed ID: 21513747
    [Abstract] [Full Text] [Related]

  • 19. Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: effect of nicotine treatment.
    Hedberg MM, Svedberg MM, Mustafiz T, Yu WF, Mousavi M, Guan ZZ, Unger C, Nordberg A.
    Neuroscience; 2008 Mar 03; 152(1):223-33. PubMed ID: 18164554
    [Abstract] [Full Text] [Related]

  • 20. 4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of β-secretase activity.
    Lee YJ, Choi DY, Lee YK, Lee YM, Han SB, Kim YH, Kim KH, Nam SY, Lee BJ, Kang JK, Yun YW, Oh KW, Hong JT.
    J Alzheimers Dis; 2012 Mar 03; 29(3):677-90. PubMed ID: 22330831
    [Abstract] [Full Text] [Related]

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