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Journal Abstract Search

134 related items for PubMed ID: 20167000

  • 1. New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part II.
    Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF.
    Curr Drug Metab; 2009 Dec; 10(10):1127-50. PubMed ID: 20167000
    [Abstract] [Full Text] [Related]

  • 2. Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
    Zhou SF, Zhou ZW, Yang LP, Cai JP.
    Curr Med Chem; 2009 Dec; 16(27):3480-675. PubMed ID: 19515014
    [Abstract] [Full Text] [Related]

  • 3. New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I.
    Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF.
    Curr Drug Metab; 2009 Dec; 10(10):1075-126. PubMed ID: 20167001
    [Abstract] [Full Text] [Related]

  • 4. Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.
    Mosher CM, Hummel MA, Tracy TS, Rettie AE.
    Biochemistry; 2008 Nov 11; 47(45):11725-34. PubMed ID: 18922023
    [Abstract] [Full Text] [Related]

  • 5. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
    Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE.
    Biochemistry; 1999 Mar 16; 38(11):3285-92. PubMed ID: 10079071
    [Abstract] [Full Text] [Related]

  • 6. Assessment of arginine 97 and lysine 72 as determinants of substrate specificity in cytochrome P450 2C9 (CYP2C9).
    Davies C, Witham K, Scott JR, Pearson A, DeVoss JJ, Graham SE, Gillam EM.
    Drug Metab Dispos; 2004 Apr 16; 32(4):431-6. PubMed ID: 15039296
    [Abstract] [Full Text] [Related]

  • 7. Flexibility of human cytochromes P450: molecular dynamics reveals differences between CYPs 3A4, 2C9, and 2A6, which correlate with their substrate preferences.
    Skopalík J, Anzenbacher P, Otyepka M.
    J Phys Chem B; 2008 Jul 10; 112(27):8165-73. PubMed ID: 18598011
    [Abstract] [Full Text] [Related]

  • 8. Effective virtual screening protocol for CYP2C9 ligands using a screening site constructed from flurbiprofen and S-warfarin pockets.
    Polgár T, Menyhárd DK, Keseru GM.
    J Comput Aided Mol Des; 2007 Sep 10; 21(9):539-48. PubMed ID: 17960328
    [Abstract] [Full Text] [Related]

  • 9. Prediction of metabolism by cytochrome P450 2C9: alignment and docking studies of a validated database of substrates.
    Sykes MJ, McKinnon RA, Miners JO.
    J Med Chem; 2008 Feb 28; 51(4):780-91. PubMed ID: 18237107
    [Abstract] [Full Text] [Related]

  • 10. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.
    Wester MR, Yano JK, Schoch GA, Yang C, Griffin KJ, Stout CD, Johnson EF.
    J Biol Chem; 2004 Aug 20; 279(34):35630-7. PubMed ID: 15181000
    [Abstract] [Full Text] [Related]

  • 11. Multiple, ligand-dependent routes from the active site of cytochrome P450 2C9.
    Cojocaru V, Winn PJ, Wade RC.
    Curr Drug Metab; 2012 Feb 20; 13(2):143-54. PubMed ID: 22208529
    [Abstract] [Full Text] [Related]

  • 12. Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
    Melet A, Marques-Soares C, Schoch GA, Macherey AC, Jaouen M, Dansette PM, Sari MA, Johnson EF, Mansuy D.
    Biochemistry; 2004 Dec 14; 43(49):15379-92. PubMed ID: 15581350
    [Abstract] [Full Text] [Related]

  • 13. Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.
    Afzelius L, Raubacher F, Karlén A, Jørgensen FS, Andersson TB, Masimirembwa CM, Zamora I.
    Drug Metab Dispos; 2004 Nov 14; 32(11):1218-29. PubMed ID: 15483192
    [Abstract] [Full Text] [Related]

  • 14. Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9.
    Tsao CC, Wester MR, Ghanayem B, Coulter SJ, Chanas B, Johnson EF, Goldstein JA.
    Biochemistry; 2001 Feb 20; 40(7):1937-44. PubMed ID: 11329260
    [Abstract] [Full Text] [Related]

  • 15. Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.
    Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR.
    J Biol Chem; 2004 Jun 25; 279(26):27294-301. PubMed ID: 15100217
    [Abstract] [Full Text] [Related]

  • 16. Multiple molecular dynamics simulations of human p450 monooxygenase CYP2C9: the molecular basis of substrate binding and regioselectivity toward warfarin.
    Seifert A, Tatzel S, Schmid RD, Pleiss J.
    Proteins; 2006 Jul 01; 64(1):147-55. PubMed ID: 16639745
    [Abstract] [Full Text] [Related]

  • 17. Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19.
    Reynald RL, Sansen S, Stout CD, Johnson EF.
    J Biol Chem; 2012 Dec 28; 287(53):44581-91. PubMed ID: 23118231
    [Abstract] [Full Text] [Related]

  • 18. The molecular basis of dapsone activation of CYP2C9-catalyzed nonsteroidal anti-inflammatory drug oxidation.
    Nair PC, Burns K, Chau N, McKinnon RA, Miners JO.
    J Biol Chem; 2023 Dec 28; 299(12):105368. PubMed ID: 37866634
    [Abstract] [Full Text] [Related]

  • 19. Structural and energetic analysis to provide insight residues of CYP2C9, 2C11 and 2E1 involved in valproic acid dehydrogenation selectivity.
    Bello M, Mendieta-Wejebe JE, Correa-Basurto J.
    Biochem Pharmacol; 2014 Jul 15; 90(2):145-58. PubMed ID: 24794636
    [Abstract] [Full Text] [Related]

  • 20. Effector-mediated alteration of substrate orientation in cytochrome P450 2C9.
    Hummel MA, Gannett PM, Aguilar JS, Tracy TS.
    Biochemistry; 2004 Jun 08; 43(22):7207-14. PubMed ID: 15170358
    [Abstract] [Full Text] [Related]

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