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Journal Abstract Search

153 related items for PubMed ID: 20184326

  • 1. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
    Shen HC, Ding FX, Raghavan S, Deng Q, Luell S, Forrest MJ, Carballo-Jane E, Wilsie LC, Krsmanovic ML, Taggart AK, Wu KK, Wu TJ, Cheng K, Ren N, Cai TQ, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.
    J Med Chem; 2010 Mar 25; 53(6):2666-70. PubMed ID: 20184326
    [Abstract] [Full Text] [Related]

  • 2. Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
    Shen HC, Ding FX, Luell S, Forrest MJ, Carballo-Jane E, Wu KK, Wu TJ, Cheng K, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Deng Q, Chen Q, Wang J, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.
    J Med Chem; 2007 Dec 13; 50(25):6303-6. PubMed ID: 17994679
    [Abstract] [Full Text] [Related]

  • 3. Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
    Shen HC, Ding FX, Deng Q, Wilsie LC, Krsmanovic ML, Taggart AK, Carballo-Jane E, Ren N, Cai TQ, Wu TJ, Wu KK, Cheng K, Chen Q, Wolff MS, Tong X, Holt TG, Waters MG, Hammond ML, Tata JR, Colletti SL.
    J Med Chem; 2009 Apr 23; 52(8):2587-602. PubMed ID: 19309152
    [Abstract] [Full Text] [Related]

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  • 5. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor.
    Kim HY, Jadhav VB, Jeong DY, Park WK, Song JH, Lee S, Cho H.
    Arch Pharm Res; 2015 Jun 23; 38(6):1019-32. PubMed ID: 25599616
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  • 7. Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.
    Ding FX, Shen HC, Wilsie LC, Krsmanovic ML, Taggart AK, Ren N, Cai TQ, Wang J, Tong X, Holt TG, Chen Q, Waters MG, Hammond ML, Tata JR, Colletti SL.
    Bioorg Med Chem Lett; 2010 Jun 01; 20(11):3372-5. PubMed ID: 20452209
    [Abstract] [Full Text] [Related]

  • 8. Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.
    Skinner PJ, Cherrier MC, Webb PJ, Shin YJ, Gharbaoui T, Lindstrom A, Hong V, Tamura SY, Dang HT, Pride CC, Chen R, Richman JG, Connolly DT, Semple G.
    Bioorg Med Chem Lett; 2007 Oct 15; 17(20):5620-3. PubMed ID: 17804224
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  • 10. 3-Nitro-4-amino benzoic acids and 6-amino nicotinic acids are highly selective agonists of GPR109b.
    Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Dang HT, Pride CC, Chen R, Tamura SY, Richman JG, Connolly DT, Semple G.
    Bioorg Med Chem Lett; 2007 Dec 01; 17(23):6619-22. PubMed ID: 17931863
    [Abstract] [Full Text] [Related]

  • 11. 3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.
    Semple G, Skinner PJ, Gharbaoui T, Shin YJ, Jung JK, Cherrier MC, Webb PJ, Tamura SY, Boatman PD, Sage CR, Schrader TO, Chen R, Colletti SL, Tata JR, Waters MG, Cheng K, Taggart AK, Cai TQ, Carballo-Jane E, Behan DP, Connolly DT, Richman JG.
    J Med Chem; 2008 Aug 28; 51(16):5101-8. PubMed ID: 18665582
    [Abstract] [Full Text] [Related]

  • 12. Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74.
    Mahboubi K, Witman-Jones T, Adamus JE, Letsinger JT, Whitehouse D, Moorman AR, Sawicki D, Bergenhem N, Ross SA.
    Biochem Biophys Res Commun; 2006 Feb 10; 340(2):482-90. PubMed ID: 16389067
    [Abstract] [Full Text] [Related]

  • 13. (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
    Boatman PD, Lauring B, Schrader TO, Kasem M, Johnson BR, Skinner P, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Luo WL, Caro L, Cote J, Lai E, Wagner J, Taggart AK, Carballo-Jane E, Hammond M, Colletti SL, Tata JR, Connolly DT, Waters MG, Richman JG.
    J Med Chem; 2012 Apr 26; 55(8):3644-66. PubMed ID: 22435740
    [Abstract] [Full Text] [Related]

  • 14. 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
    Semple G, Skinner PJ, Cherrier MC, Webb PJ, Sage CR, Tamura SY, Chen R, Richman JG, Connolly DT.
    J Med Chem; 2006 Feb 23; 49(4):1227-30. PubMed ID: 16480258
    [Abstract] [Full Text] [Related]

  • 15. Potent tricyclic pyrazole tetrazole agonists of the nicotinic acid receptor (GPR109a).
    Boatman PD, Schrader TO, Kasem M, Johnson BR, Skinner PJ, Jung JK, Xu J, Cherrier MC, Webb PJ, Semple G, Sage CR, Knudsen J, Chen R, Taggart AK, Carballo-Jane E, Richman JG.
    Bioorg Med Chem Lett; 2010 May 01; 20(9):2797-800. PubMed ID: 20363624
    [Abstract] [Full Text] [Related]

  • 16. Niacin stimulates adiponectin secretion through the GPR109A receptor.
    Plaisance EP, Lukasova M, Offermanns S, Zhang Y, Cao G, Judd RL.
    Am J Physiol Endocrinol Metab; 2009 Mar 01; 296(3):E549-58. PubMed ID: 19141678
    [Abstract] [Full Text] [Related]

  • 17. The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.
    Imbriglio JE, DiRocco D, Bodner R, Raghavan S, Chen W, Marley D, Esser C, Holt TG, Wolff MS, Taggart AK, Waters MG, Tata JR, Colletti SL.
    Bioorg Med Chem Lett; 2011 May 01; 21(9):2721-4. PubMed ID: 21185185
    [Abstract] [Full Text] [Related]

  • 18. Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.
    Carballo-Jane E, Gerckens LS, Luell S, Parlapiano AS, Wolff M, Colletti SL, Tata JR, Taggart AK, Waters MG, Richman JG, McCann ME, Forrest MJ.
    J Pharmacol Toxicol Methods; 2007 May 01; 56(3):308-16. PubMed ID: 17643322
    [Abstract] [Full Text] [Related]

  • 19. GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.
    Imbriglio JE, Chang S, Liang R, Raghavan S, Schmidt D, Smenton A, Tria S, Schrader TO, Jung JK, Esser C, Holt TG, Wolff MS, Taggart AK, Cheng K, Carballo-Jane E, Waters MG, Tata JR, Colletti SL.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4472-4. PubMed ID: 20615702
    [Abstract] [Full Text] [Related]

  • 20. Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.
    Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S.
    Bioorg Med Chem Lett; 2010 Sep 15; 20(18):5426-30. PubMed ID: 20724150
    [Abstract] [Full Text] [Related]

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