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206 related items for PubMed ID: 20186341

  • 1. HAMLET interacts with lipid membranes and perturbs their structure and integrity.
    Mossberg AK, Puchades M, Halskau Ø, Baumann A, Lanekoff I, Chao Y, Martinez A, Svanborg C, Karlsson R.
    PLoS One; 2010 Feb 23; 5(2):e9384. PubMed ID: 20186341
    [Abstract] [Full Text] [Related]

  • 2. Cytotoxicity of bovine α-lactalbumin: oleic acid complexes correlates with the disruption of lipid membranes.
    Wen H, Glomm WR, Halskau O.
    Biochim Biophys Acta; 2013 Nov 23; 1828(11):2691-9. PubMed ID: 23916586
    [Abstract] [Full Text] [Related]

  • 3. Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).
    Svensson M, Fast J, Mossberg AK, Düringer C, Gustafsson L, Hallgren O, Brooks CL, Berliner L, Linse S, Svanborg C.
    Protein Sci; 2003 Dec 23; 12(12):2794-804. PubMed ID: 14627739
    [Abstract] [Full Text] [Related]

  • 4. alpha-Lactalbumin, engineered to be nonnative and inactive, kills tumor cells when in complex with oleic acid: a new biological function resulting from partial unfolding.
    Pettersson-Kastberg J, Mossberg AK, Trulsson M, Yong YJ, Min S, Lim Y, O'Brien JE, Svanborg C, Mok KH.
    J Mol Biol; 2009 Dec 18; 394(5):994-1010. PubMed ID: 19766653
    [Abstract] [Full Text] [Related]

  • 5. Who is Mr. HAMLET? Interaction of human alpha-lactalbumin with monomeric oleic acid.
    Knyazeva EL, Grishchenko VM, Fadeev RS, Akatov VS, Permyakov SE, Permyakov EA.
    Biochemistry; 2008 Dec 09; 47(49):13127-37. PubMed ID: 19006329
    [Abstract] [Full Text] [Related]

  • 6. Lipids as tumoricidal components of human α-lactalbumin made lethal to tumor cells (HAMLET): unique and shared effects on signaling and death.
    Ho JC, Storm P, Rydström A, Bowen B, Alsin F, Sullivan L, Ambite I, Mok KH, Northen T, Svanborg C.
    J Biol Chem; 2013 Jun 14; 288(24):17460-71. PubMed ID: 23629662
    [Abstract] [Full Text] [Related]

  • 7. Changes in proteasome structure and function caused by HAMLET in tumor cells.
    Gustafsson L, Aits S, Onnerfjord P, Trulsson M, Storm P, Svanborg C.
    PLoS One; 2009 Jun 14; 4(4):e5229. PubMed ID: 19365565
    [Abstract] [Full Text] [Related]

  • 8. Applications of site-specific labeling to study HAMLET, a tumoricidal complex of α-lactalbumin and oleic acid.
    Mercer N, Ramakrishnan B, Boeggeman E, Qasba PK.
    PLoS One; 2011 Jun 14; 6(10):e26093. PubMed ID: 22016817
    [Abstract] [Full Text] [Related]

  • 9. Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex.
    Nadeem A, Sanborn J, Gettel DL, James HC, Rydström A, Ngassam VN, Klausen TK, Pedersen SF, Lam M, Parikh AN, Svanborg C.
    Sci Rep; 2015 Nov 12; 5():16432. PubMed ID: 26561036
    [Abstract] [Full Text] [Related]

  • 10. Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.
    Mossberg AK, Hun Mok K, Morozova-Roche LA, Svanborg C.
    FEBS J; 2010 Nov 12; 277(22):4614-25. PubMed ID: 20977665
    [Abstract] [Full Text] [Related]

  • 11. Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity.
    Ho CS, Rydstrom A, Manimekalai MS, Svanborg C, Grüber G.
    PLoS One; 2012 Nov 12; 7(12):e53051. PubMed ID: 23300861
    [Abstract] [Full Text] [Related]

  • 12. Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.
    Fischer W, Gustafsson L, Mossberg AK, Gronli J, Mork S, Bjerkvig R, Svanborg C.
    Cancer Res; 2004 Mar 15; 64(6):2105-12. PubMed ID: 15026350
    [Abstract] [Full Text] [Related]

  • 13. Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein-lipid complexes.
    Ho JCS, Mir SA, Cavalera M, Esmaeili P, Tran TH, Yann ZC, Tran TH, Chaudhuri A, Bendt AK, Wenk MR, Svanborg C.
    Biofactors; 2022 Sep 15; 48(5):1145-1159. PubMed ID: 35388547
    [Abstract] [Full Text] [Related]

  • 14. alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids.
    Rødland I, Halskau Ø, Martínez A, Holmsen H.
    Biochim Biophys Acta; 2005 Nov 10; 1717(1):11-20. PubMed ID: 16271262
    [Abstract] [Full Text] [Related]

  • 15. Compact oleic acid in HAMLET.
    Fast J, Mossberg AK, Nilsson H, Svanborg C, Akke M, Linse S.
    FEBS Lett; 2005 Nov 07; 579(27):6095-100. PubMed ID: 16229842
    [Abstract] [Full Text] [Related]

  • 16. HAMLET forms annular oligomers when deposited with phospholipid monolayers.
    Baumann A, Gjerde AU, Ying M, Svanborg C, Holmsen H, Glomm WR, Martinez A, Halskau O.
    J Mol Biol; 2012 Apr 20; 418(1-2):90-102. PubMed ID: 22343047
    [Abstract] [Full Text] [Related]

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  • 19. Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex.
    Fast J, Mossberg AK, Svanborg C, Linse S.
    Protein Sci; 2005 Feb 20; 14(2):329-40. PubMed ID: 15659367
    [Abstract] [Full Text] [Related]

  • 20. Molecular mechanisms of the cytotoxicity of human α-lactalbumin made lethal to tumor cells (HAMLET) and other protein-oleic acid complexes.
    Nakamura T, Aizawa T, Kariya R, Okada S, Demura M, Kawano K, Makabe K, Kuwajima K.
    J Biol Chem; 2013 May 17; 288(20):14408-14416. PubMed ID: 23580643
    [Abstract] [Full Text] [Related]

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