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Journal Abstract Search

444 related items for PubMed ID: 20190739

  • 1. Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.
    Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N.
    Nat Biotechnol; 2010 Mar; 28(3):256-63. PubMed ID: 20190739
    [Abstract] [Full Text] [Related]

  • 2. The role of chaperone-mediated autophagy in huntingtin degradation.
    Qi L, Zhang XD, Wu JC, Lin F, Wang J, DiFiglia M, Qin ZH.
    PLoS One; 2012 Mar; 7(10):e46834. PubMed ID: 23071649
    [Abstract] [Full Text] [Related]

  • 3. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
    Wong YC, Holzbaur EL.
    J Neurosci; 2014 Jan 22; 34(4):1293-305. PubMed ID: 24453320
    [Abstract] [Full Text] [Related]

  • 4. Role of chaperone-mediated autophagy in degrading Huntington's disease-associated huntingtin protein.
    Qi L, Zhang XD.
    Acta Biochim Biophys Sin (Shanghai); 2014 Feb 22; 46(2):83-91. PubMed ID: 24323530
    [Abstract] [Full Text] [Related]

  • 5. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
    Busch A, Engemann S, Lurz R, Okazawa H, Lehrach H, Wanker EE.
    J Biol Chem; 2003 Oct 17; 278(42):41452-61. PubMed ID: 12888569
    [Abstract] [Full Text] [Related]

  • 6. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments.
    Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S.
    Hum Mol Genet; 2010 Jun 15; 19(12):2445-55. PubMed ID: 20354076
    [Abstract] [Full Text] [Related]

  • 7. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.
    Zheng S, Clabough EB, Sarkar S, Futter M, Rubinsztein DC, Zeitlin SO.
    PLoS Genet; 2010 Feb 05; 6(2):e1000838. PubMed ID: 20140187
    [Abstract] [Full Text] [Related]

  • 8. Clearance of mutant huntingtin.
    Li XJ, Li H, Li S.
    Autophagy; 2010 Jul 05; 6(5):663-4. PubMed ID: 20519964
    [Abstract] [Full Text] [Related]

  • 9. Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin.
    Chafekar SM, Duennwald ML.
    PLoS One; 2012 Jul 05; 7(5):e37929. PubMed ID: 22649566
    [Abstract] [Full Text] [Related]

  • 10. Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins.
    Huang CC, Faber PW, Persichetti F, Mittal V, Vonsattel JP, MacDonald ME, Gusella JF.
    Somat Cell Mol Genet; 1998 Jul 05; 24(4):217-33. PubMed ID: 10410676
    [Abstract] [Full Text] [Related]

  • 11. Effects of overexpression of huntingtin proteins on mitochondrial integrity.
    Wang H, Lim PJ, Karbowski M, Monteiro MJ.
    Hum Mol Genet; 2009 Feb 15; 18(4):737-52. PubMed ID: 19039036
    [Abstract] [Full Text] [Related]

  • 12. Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.
    Davranche A, Aviolat H, Zeder-Lutz G, Busso D, Altschuh D, Trottier Y, Klein FA.
    Hum Mol Genet; 2011 Jul 15; 20(14):2795-806. PubMed ID: 21518730
    [Abstract] [Full Text] [Related]

  • 13. The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.
    Tagawa K, Marubuchi S, Qi ML, Enokido Y, Tamura T, Inagaki R, Murata M, Kanazawa I, Wanker EE, Okazawa H.
    J Neurosci; 2007 Jan 24; 27(4):868-80. PubMed ID: 17251428
    [Abstract] [Full Text] [Related]

  • 14. Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.
    Luo S, Vacher C, Davies JE, Rubinsztein DC.
    J Cell Biol; 2005 May 23; 169(4):647-56. PubMed ID: 15911879
    [Abstract] [Full Text] [Related]

  • 15. A huntingtin peptide inhibits polyQ-huntingtin associated defects.
    Arribat Y, Bonneaud N, Talmat-Amar Y, Layalle S, Parmentier ML, Maschat F.
    PLoS One; 2013 May 23; 8(7):e68775. PubMed ID: 23861941
    [Abstract] [Full Text] [Related]

  • 16. Polyglutamine tracts regulate beclin 1-dependent autophagy.
    Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC.
    Nature; 2017 May 04; 545(7652):108-111. PubMed ID: 28445460
    [Abstract] [Full Text] [Related]

  • 17. A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.
    Poirier MA, Jiang H, Ross CA.
    Hum Mol Genet; 2005 Mar 15; 14(6):765-74. PubMed ID: 15689354
    [Abstract] [Full Text] [Related]

  • 18. Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model.
    Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I.
    J Neurosci; 2009 Feb 04; 29(5):1257-66. PubMed ID: 19193873
    [Abstract] [Full Text] [Related]

  • 19. PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD).
    Ratovitski T, Arbez N, Stewart JC, Chighladze E, Ross CA.
    Cell Cycle; 2015 Feb 04; 14(11):1716-29. PubMed ID: 25927346
    [Abstract] [Full Text] [Related]

  • 20. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
    Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ.
    J Neurosci; 2008 Mar 12; 28(11):2783-92. PubMed ID: 18337408
    [Abstract] [Full Text] [Related]

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