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Journal Abstract Search

444 related items for PubMed ID: 20190739

  • 21. Inhibition of Rho kinases enhances the degradation of mutant huntingtin.
    Bauer PO, Wong HK, Oyama F, Goswami A, Okuno M, Kino Y, Miyazaki H, Nukina N.
    J Biol Chem; 2009 May 08; 284(19):13153-64. PubMed ID: 19278999
    [Abstract] [Full Text] [Related]

  • 22. Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA).
    Jiang YJ, Che MX, Yuan JQ, Xie YY, Yan XZ, Hu HY.
    J Biol Chem; 2011 Jul 15; 286(28):25236-45. PubMed ID: 21566141
    [Abstract] [Full Text] [Related]

  • 23. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.
    Nguyen T, Hamby A, Massa SM.
    Proc Natl Acad Sci U S A; 2005 Aug 16; 102(33):11840-5. PubMed ID: 16087879
    [Abstract] [Full Text] [Related]

  • 24.
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  • 25. scyllo-Inositol promotes robust mutant Huntingtin protein degradation.
    Lai AY, Lan CP, Hasan S, Brown ME, McLaurin J.
    J Biol Chem; 2014 Feb 07; 289(6):3666-76. PubMed ID: 24352657
    [Abstract] [Full Text] [Related]

  • 26. Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors.
    Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D, Petersén Å.
    Eur J Neurosci; 2012 Sep 07; 36(6):2789-800. PubMed ID: 22731249
    [Abstract] [Full Text] [Related]

  • 27. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
    Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F.
    J Clin Invest; 2011 Nov 07; 121(11):4372-82. PubMed ID: 21985783
    [Abstract] [Full Text] [Related]

  • 28. CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice.
    Apostol BL, Simmons DA, Zuccato C, Illes K, Pallos J, Casale M, Conforti P, Ramos C, Roarke M, Kathuria S, Cattaneo E, Marsh JL, Thompson LM.
    Mol Cell Neurosci; 2008 Sep 07; 39(1):8-20. PubMed ID: 18602275
    [Abstract] [Full Text] [Related]

  • 29. Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin.
    Miller SLH, Scappini EL, O'Bryan J.
    J Biol Chem; 2007 Mar 30; 282(13):10096-10103. PubMed ID: 17276991
    [Abstract] [Full Text] [Related]

  • 30. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
    Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ.
    PLoS Genet; 2016 May 30; 12(5):e1006083. PubMed ID: 27203582
    [Abstract] [Full Text] [Related]

  • 31. Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
    Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR.
    J Neurosci; 2002 Sep 15; 22(18):7862-72. PubMed ID: 12223539
    [Abstract] [Full Text] [Related]

  • 32. Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
    Huang B, Schiefer J, Sass C, Kosinski CM, Kochanek S.
    J Gene Med; 2008 Mar 15; 10(3):269-79. PubMed ID: 18067195
    [Abstract] [Full Text] [Related]

  • 33. [Selective degradation of expanded polyglutamine proteins by their specific recognition with QBP1].
    Nagai Y, Nukina N.
    Rinsho Shinkeigaku; 2011 Nov 15; 51(11):1108-10. PubMed ID: 22277499
    [Abstract] [Full Text] [Related]

  • 34. Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.
    André EA, Braatz EM, Liu JP, Zeitlin SO.
    J Huntingtons Dis; 2017 Nov 15; 6(1):47-62. PubMed ID: 28211815
    [Abstract] [Full Text] [Related]

  • 35. Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin.
    Wang H, Lim PJ, Yin C, Rieckher M, Vogel BE, Monteiro MJ.
    Hum Mol Genet; 2006 Mar 15; 15(6):1025-41. PubMed ID: 16461334
    [Abstract] [Full Text] [Related]

  • 36. Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
    Chan EY, Luthi-Carter R, Strand A, Solano SM, Hanson SA, DeJohn MM, Kooperberg C, Chase KO, DiFiglia M, Young AB, Leavitt BR, Cha JH, Aronin N, Hayden MR, Olson JM.
    Hum Mol Genet; 2002 Aug 15; 11(17):1939-51. PubMed ID: 12165556
    [Abstract] [Full Text] [Related]

  • 37. Towards a transgenic model of Huntington's disease in a non-human primate.
    Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW.
    Nature; 2008 Jun 12; 453(7197):921-4. PubMed ID: 18488016
    [Abstract] [Full Text] [Related]

  • 38. Hsp40 gene therapy exerts therapeutic effects on polyglutamine disease mice via a non-cell autonomous mechanism.
    Popiel HA, Takeuchi T, Fujita H, Yamamoto K, Ito C, Yamane H, Muramatsu S, Toda T, Wada K, Nagai Y.
    PLoS One; 2012 Jun 12; 7(11):e51069. PubMed ID: 23226463
    [Abstract] [Full Text] [Related]

  • 39. Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
    Zhang H, Li Q, Graham RK, Slow E, Hayden MR, Bezprozvanny I.
    Neurobiol Dis; 2008 Jul 12; 31(1):80-8. PubMed ID: 18502655
    [Abstract] [Full Text] [Related]

  • 40. Degradation of misfolded proteins by autophagy: is it a strategy for Huntington's disease treatment?
    Lin F, Qin ZH.
    J Huntingtons Dis; 2013 Jul 12; 2(2):149-57. PubMed ID: 25063512
    [Abstract] [Full Text] [Related]

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