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Journal Abstract Search

204 related items for PubMed ID: 20194504

  • 1. Origin of the allyl group in FK506 biosynthesis.
    Goranovic D, Kosec G, Mrak P, Fujs S, Horvat J, Kuscer E, Kopitar G, Petkovic H.
    J Biol Chem; 2010 May 07; 285(19):14292-300. PubMed ID: 20194504
    [Abstract] [Full Text] [Related]

  • 2. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
    Wu K, Chung L, Revill WP, Katz L, Reeves CD.
    Gene; 2000 Jun 13; 251(1):81-90. PubMed ID: 10863099
    [Abstract] [Full Text] [Related]

  • 3. Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.
    Chen D, Zhang Q, Zhang Q, Cen P, Xu Z, Liu W.
    Appl Environ Microbiol; 2012 Aug 13; 78(15):5093-103. PubMed ID: 22582065
    [Abstract] [Full Text] [Related]

  • 4. Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis.
    Blažič M, Kosec G, Baebler Š, Gruden K, Petković H.
    Microb Cell Fact; 2015 Oct 14; 14():164. PubMed ID: 26466669
    [Abstract] [Full Text] [Related]

  • 5. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
    Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ.
    J Am Chem Soc; 2011 Feb 02; 133(4):976-85. PubMed ID: 21175203
    [Abstract] [Full Text] [Related]

  • 6. Improvement of FK506 Production in the High-Yielding Strain Streptomyces sp. RM7011 by Engineering the Supply of Allylmalonyl-CoA Through a Combination of Genetic and Chemical Approach.
    Mo S, Lee SK, Jin YY, Suh JW.
    J Microbiol Biotechnol; 2016 Feb 02; 26(2):233-40. PubMed ID: 26502733
    [Abstract] [Full Text] [Related]

  • 7. Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes.
    Ordóñez-Robles M, Rodríguez-García A, Martín JF.
    Appl Microbiol Biotechnol; 2016 Sep 02; 100(18):8091-103. PubMed ID: 27357227
    [Abstract] [Full Text] [Related]

  • 8. Roles of fkbN in positive regulation and tcs7 in negative regulation of FK506 biosynthesis in Streptomyces sp. strain KCTC 11604BP.
    Mo S, Yoo YJ, Ban YH, Lee SK, Kim E, Suh JW, Yoon YJ.
    Appl Environ Microbiol; 2012 Apr 02; 78(7):2249-55. PubMed ID: 22267670
    [Abstract] [Full Text] [Related]

  • 9. Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520.
    Motamedi H, Shafiee A, Cai SJ, Streicher SL, Arison BH, Miller RR.
    J Bacteriol; 1996 Sep 02; 178(17):5243-8. PubMed ID: 8752344
    [Abstract] [Full Text] [Related]

  • 10. Draft genome of Streptomyces tsukubaensis NRRL 18488, the producer of the clinically important immunosuppressant tacrolimus (FK506).
    Barreiro C, Prieto C, Sola-Landa A, Solera E, Martínez-Castro M, Pérez-Redondo R, García-Estrada C, Aparicio JF, Fernández-Martínez LT, Santos-Aberturas J, Salehi-Najafabadi Z, Rodríguez-García A, Tauch A, Martín JF.
    J Bacteriol; 2012 Jul 02; 194(14):3756-7. PubMed ID: 22740677
    [Abstract] [Full Text] [Related]

  • 11. Novel chemobiosynthetic approach for exclusive production of FK506.
    Kosec G, Goranovič D, Mrak P, Fujs S, Kuščer E, Horvat J, Kopitar G, Petković H.
    Metab Eng; 2012 Jan 02; 14(1):39-46. PubMed ID: 22100790
    [Abstract] [Full Text] [Related]

  • 12. The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506.
    Motamedi H, Shafiee A.
    Eur J Biochem; 1998 Sep 15; 256(3):528-34. PubMed ID: 9780228
    [Abstract] [Full Text] [Related]

  • 13. Phage p1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster.
    Jones AC, Gust B, Kulik A, Heide L, Buttner MJ, Bibb MJ.
    PLoS One; 2013 Sep 15; 8(7):e69319. PubMed ID: 23874942
    [Abstract] [Full Text] [Related]

  • 14. FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis.
    Goranovič D, Blažič M, Magdevska V, Horvat J, Kuščer E, Polak T, Santos-Aberturas J, Martínez-Castro M, Barreiro C, Mrak P, Kopitar G, Kosec G, Fujs S, Martín JF, Petković H.
    BMC Microbiol; 2012 Oct 19; 12():238. PubMed ID: 23083511
    [Abstract] [Full Text] [Related]

  • 15. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19.
    Zhang XS, Luo HD, Tao Y, Wang YY, Jiang XH, Jiang H, Li YQ.
    J Ind Microbiol Biotechnol; 2016 Dec 19; 43(12):1693-1703. PubMed ID: 27757551
    [Abstract] [Full Text] [Related]

  • 16. Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
    Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B.
    Proc Natl Acad Sci U S A; 2011 Mar 22; 108(12):4776-81. PubMed ID: 21383123
    [Abstract] [Full Text] [Related]

  • 17. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.
    Huang D, Xia M, Li S, Wen J, Jia X.
    J Ind Microbiol Biotechnol; 2013 Sep 22; 40(9):1023-37. PubMed ID: 23779221
    [Abstract] [Full Text] [Related]

  • 18. Metabolic network model guided engineering ethylmalonyl-CoA pathway to improve ascomycin production in Streptomyces hygroscopicus var. ascomyceticus.
    Wang J, Wang C, Song K, Wen J.
    Microb Cell Fact; 2017 Oct 03; 16(1):169. PubMed ID: 28974216
    [Abstract] [Full Text] [Related]

  • 19. Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506.
    Motamedi H, Cai SJ, Shafiee A, Elliston KO.
    Eur J Biochem; 1997 Feb 15; 244(1):74-80. PubMed ID: 9063448
    [Abstract] [Full Text] [Related]

  • 20. Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis.
    Wu QB, Zhang XY, Chen XA, Li YQ.
    Microb Cell Fact; 2021 Aug 23; 20(1):166. PubMed ID: 34425854
    [Abstract] [Full Text] [Related]

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