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66 related items for PubMed ID: 20211594

  • 1. Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents.
    Larsson AK, Shokeer A, Mannervik B.
    Arch Biochem Biophys; 2010 May; 497(1-2):28-34. PubMed ID: 20211594
    [Abstract] [Full Text] [Related]

  • 2. The polymorphic human glutathione transferase T1-1, the most efficient glutathione transferase in the denitrosation and inactivation of the anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Lien S, Larsson AK, Mannervik B.
    Biochem Pharmacol; 2002 Jan 15; 63(2):191-7. PubMed ID: 11841793
    [Abstract] [Full Text] [Related]

  • 3. Evolution of differential substrate specificities in Mu class glutathione transferases probed by DNA shuffling.
    Hansson LO, Bolton-Grob R, Massoud T, Mannervik B.
    J Mol Biol; 1999 Mar 26; 287(2):265-76. PubMed ID: 10080890
    [Abstract] [Full Text] [Related]

  • 4. Contribution of glutathione transferase M3-3 to 1,3-bis(2-chloroethyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line.
    Berhane K, Hao XY, Egyházi S, Hansson J, Ringborg U, Mannervik B.
    Cancer Res; 1993 Sep 15; 53(18):4257-61. PubMed ID: 8395980
    [Abstract] [Full Text] [Related]

  • 5. Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines.
    Ali-Osman F, Stein DE, Renwick A.
    Cancer Res; 1990 Nov 01; 50(21):6976-80. PubMed ID: 2208164
    [Abstract] [Full Text] [Related]

  • 6. Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
    Kurtovic S, Modén O, Shokeer A, Mannervik B.
    J Mol Biol; 2008 Feb 01; 375(5):1365-79. PubMed ID: 18155239
    [Abstract] [Full Text] [Related]

  • 7. Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: effect on cellular sensitivity to cytotoxic agents.
    Townsend AJ, Tu CP, Cowan KH.
    Mol Pharmacol; 1992 Feb 01; 41(2):230-6. PubMed ID: 1538704
    [Abstract] [Full Text] [Related]

  • 8. An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes.
    Broo K, Larsson AK, Jemth P, Mannervik B.
    J Mol Biol; 2002 Apr 19; 318(1):59-70. PubMed ID: 12054768
    [Abstract] [Full Text] [Related]

  • 9. Cross-resistance and glutathione-S-transferase-pi levels among four human melanoma cell lines selected for alkylating agent resistance.
    Wang YY, Teicher BA, Shea TC, Holden SA, Rosbe KW, al-Achi A, Henner WD.
    Cancer Res; 1989 Nov 15; 49(22):6185-92. PubMed ID: 2804968
    [Abstract] [Full Text] [Related]

  • 10. Redesign of substrate-selectivity determining modules of glutathione transferase A1-1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation.
    Nilsson LO, Gustafsson A, Mannervik B.
    Proc Natl Acad Sci U S A; 2000 Aug 15; 97(17):9408-12. PubMed ID: 10900265
    [Abstract] [Full Text] [Related]

  • 11. Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.
    Pandya U, Srivastava SK, Singhal SS, Pal A, Awasthi S, Zimniak P, Awasthi YC, Singh SV.
    Biochem Biophys Res Commun; 2000 Nov 11; 278(1):258-62. PubMed ID: 11071881
    [Abstract] [Full Text] [Related]

  • 12.
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  • 13. Decreased DNA interstrand cross-linking and cytotoxicity induced in human brain tumor cells by 1,3-bis(2-chloroethyl)-1-nitrosourea after in vitro reaction with glutathione.
    Ali-Osman F, Caughlan J, Gray GS.
    Cancer Res; 1989 Nov 01; 49(21):5954-8. PubMed ID: 2551496
    [Abstract] [Full Text] [Related]

  • 14. Kinetic characterization of recombinant human glutathione transferase T1-1, a polymorphic detoxication enzyme.
    Jemth P, Mannervik B.
    Arch Biochem Biophys; 1997 Dec 15; 348(2):247-54. PubMed ID: 9434735
    [Abstract] [Full Text] [Related]

  • 15. Generation and functional characterization of mice with a disrupted glutathione S-transferase, theta 1 gene.
    Fujimoto K, Arakawa S, Watanabe T, Yasumo H, Ando Y, Takasaki W, Manabe S, Yamoto T, Oda S.
    Drug Metab Dispos; 2007 Dec 15; 35(12):2196-202. PubMed ID: 17827337
    [Abstract] [Full Text] [Related]

  • 16. Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells.
    Smith MT, Evans CG, Doane-Setzer P, Castro VM, Tahir MK, Mannervik B.
    Cancer Res; 1989 May 15; 49(10):2621-5. PubMed ID: 2713846
    [Abstract] [Full Text] [Related]

  • 17. Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.
    Srivastava SK, Singhal SS, Hu X, Awasthi YC, Zimniak P, Singh SV.
    Arch Biochem Biophys; 1999 Jun 01; 366(1):89-94. PubMed ID: 10334868
    [Abstract] [Full Text] [Related]

  • 18. Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide.
    Singh SV, Varma V, Zimniak P, Srivastava SK, Marynowski SW, Desai D, Amin S, Ji X.
    Biochemistry; 2004 Aug 03; 43(30):9708-15. PubMed ID: 15274625
    [Abstract] [Full Text] [Related]

  • 19. Novel omega glutathione S-transferases in disk abalone: Characterization and protective roles against environmental stress.
    Wan Q, Whang I, Lee JS, Lee J.
    Comp Biochem Physiol C Toxicol Pharmacol; 2009 Nov 03; 150(4):558-68. PubMed ID: 19689930
    [Abstract] [Full Text] [Related]

  • 20. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.
    Comstock KE, Widersten M, Hao XY, Henner WD, Mannervik B.
    Arch Biochem Biophys; 1994 Jun 03; 311(2):487-95. PubMed ID: 8203914
    [Abstract] [Full Text] [Related]

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