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Journal Abstract Search

193 related items for PubMed ID: 20218628

  • 1. Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.
    Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE.
    J Med Chem; 2010 Apr 08; 53(7):2927-41. PubMed ID: 20218628
    [Abstract] [Full Text] [Related]

  • 2. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
    Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE.
    J Med Chem; 2004 Feb 26; 47(5):1161-74. PubMed ID: 14971896
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  • 3. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.
    Kamal A, Ramulu P, Srinivas O, Ramesh G, Kumar PP.
    Bioorg Med Chem Lett; 2004 Sep 20; 14(18):4791-4. PubMed ID: 15324909
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  • 4. Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
    Thurston DE, Bose DS, Howard PW, Jenkins TC, Leoni A, Baraldi PG, Guiotto A, Cacciari B, Kelland LR, Foloppe MP, Rault S.
    J Med Chem; 1999 Jun 03; 42(11):1951-64. PubMed ID: 10354403
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
    Kamal A, Srinivas O, Ramulu P, Ramesh G, Kumar PP, Kumar MS.
    Bioorg Med Chem; 2004 Aug 15; 12(16):4337-50. PubMed ID: 15265486
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  • 8. Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).
    Tiberghien AC, Hagan D, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2004 Oct 18; 14(20):5041-4. PubMed ID: 15380195
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  • 10. 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
    Kamal A, Khan MN, Reddy KS, Ahmed SK, Kumar MS, Juvekar A, Sen S, Zingde S.
    Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5345-8. PubMed ID: 17723301
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  • 12. Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity.
    Kamal A, Shankaraiah N, Devaiah V, Laxma Reddy K, Juvekar A, Sen S, Kurian N, Zingde S.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1468-73. PubMed ID: 18207392
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  • 13. Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.
    Howard PW, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Cooper N, Fang M, Coffils MJ, Klee S, Hartley JA, Thurston DE.
    Bioorg Med Chem Lett; 2009 Nov 15; 19(22):6463-6. PubMed ID: 19811912
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  • 14. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents.
    Wang JJ, Shen YK, Hu WP, Hsieh MC, Lin FL, Hsu MK, Hsu MH.
    J Med Chem; 2006 Feb 23; 49(4):1442-9. PubMed ID: 16480280
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  • 15. Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.
    Kamal A, Devaiah V, Reddy KL, Kumar MS.
    Bioorg Med Chem; 2005 Mar 15; 13(6):2021-9. PubMed ID: 15727856
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  • 16. Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.
    Masterson LA, Croker SJ, Jenkins TC, Howard PW, Thurston DE.
    Bioorg Med Chem Lett; 2004 Feb 23; 14(4):901-4. PubMed ID: 15012990
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  • 17. Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity.
    Kamal A, Kumar PP, Sreekanth K, Seshadri BN, Ramulu P.
    Bioorg Med Chem Lett; 2008 Apr 15; 18(8):2594-8. PubMed ID: 18378445
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  • 18. Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity.
    Kamal A, Ramu R, Khanna GB, Saxena AK, Shanmugavel M, Pandita RM.
    Bioorg Med Chem Lett; 2004 Oct 04; 14(19):4907-9. PubMed ID: 15341949
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  • 19. Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents.
    Kamal A, Vijaya Bharathi E, Janaki Ramaiah M, Dastagiri D, Surendranadha Reddy J, Viswanath A, Sultana F, Pushpavalli SN, Pal-Bhadra M, Srivastava HK, Narahari Sastry G, Juvekar A, Sen S, Zingde S.
    Bioorg Med Chem; 2010 Jan 15; 18(2):526-42. PubMed ID: 20031423
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  • 20. Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
    Kamal A, Kumar PP, Seshadri BN, Srinivas O, Kumar MS, Sen S, Kurian N, Juvekar AS, Zingde SM.
    Bioorg Med Chem; 2008 Apr 01; 16(7):3895-906. PubMed ID: 18262426
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