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438 related items for PubMed ID: 20306249

  • 1. Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.
    Engel ME, Hiebert SW.
    Cancer Treat Res; 2010; 145():127-47. PubMed ID: 20306249
    [Abstract] [Full Text] [Related]

  • 2. Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.
    Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G.
    Blood; 2014 Mar 13; 123(11):1729-38. PubMed ID: 24449215
    [Abstract] [Full Text] [Related]

  • 3. Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.
    Tonks A, Pearn L, Musson M, Gilkes A, Mills KI, Burnett AK, Darley RL.
    Leukemia; 2007 Dec 13; 21(12):2495-505. PubMed ID: 17898786
    [Abstract] [Full Text] [Related]

  • 4. RUNX1 and CBFβ-SMMHC transactivate target genes together in abnormal myeloid progenitors for leukemia development.
    Zhen T, Cao Y, Ren G, Zhao L, Hyde RK, Lopez G, Feng D, Alemu L, Zhao K, Liu PP.
    Blood; 2020 Nov 19; 136(21):2373-2385. PubMed ID: 32929473
    [Abstract] [Full Text] [Related]

  • 5. Biological Activities of RUNX1 Mutants Predict Secondary Acute Leukemia Transformation from Chronic Myelomonocytic Leukemia and Myelodysplastic Syndromes.
    Tsai SC, Shih LY, Liang ST, Huang YJ, Kuo MC, Huang CF, Shih YS, Lin TH, Chiu MC, Liang DC.
    Clin Cancer Res; 2015 Aug 01; 21(15):3541-51. PubMed ID: 25840971
    [Abstract] [Full Text] [Related]

  • 6. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta.
    Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, Brown ML, Bushweller JH.
    Chem Biol; 2007 Oct 01; 14(10):1186-97. PubMed ID: 17961830
    [Abstract] [Full Text] [Related]

  • 7. Core binding factor genes and human leukemia.
    Hart SM, Foroni L.
    Haematologica; 2002 Dec 01; 87(12):1307-23. PubMed ID: 12495904
    [Abstract] [Full Text] [Related]

  • 8. RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation.
    Cammenga J, Niebuhr B, Horn S, Bergholz U, Putz G, Buchholz F, Löhler J, Stocking C.
    Cancer Res; 2007 Jan 15; 67(2):537-45. PubMed ID: 17234761
    [Abstract] [Full Text] [Related]

  • 9. CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia.
    Mandoli A, Singh AA, Jansen PW, Wierenga AT, Riahi H, Franci G, Prange K, Saeed S, Vellenga E, Vermeulen M, Stunnenberg HG, Martens JH.
    Leukemia; 2014 Apr 15; 28(4):770-8. PubMed ID: 24002588
    [Abstract] [Full Text] [Related]

  • 10. The AML1 gene: a transcription factor involved in the pathogenesis of myeloid and lymphoid leukemias.
    Lo Coco F, Pisegna S, Diverio D.
    Haematologica; 1997 Apr 15; 82(3):364-70. PubMed ID: 9234595
    [Abstract] [Full Text] [Related]

  • 11. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.
    Castilla LH, Bushweller JH.
    Adv Exp Med Biol; 2017 Apr 15; 962():229-244. PubMed ID: 28299661
    [Abstract] [Full Text] [Related]

  • 12. RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation.
    Kuo MC, Liang DC, Huang CF, Shih YS, Wu JH, Lin TL, Shih LY.
    Leukemia; 2009 Aug 15; 23(8):1426-31. PubMed ID: 19282830
    [Abstract] [Full Text] [Related]

  • 13. RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML.
    Hyde RK, Liu P, Friedman AD.
    Adv Exp Med Biol; 2017 Aug 15; 962():265-282. PubMed ID: 28299663
    [Abstract] [Full Text] [Related]

  • 14. CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
    Roudaia L, Cheney MD, Manuylova E, Chen W, Morrow M, Park S, Lee CT, Kaur P, Williams O, Bushweller JH, Speck NA.
    Blood; 2009 Mar 26; 113(13):3070-9. PubMed ID: 19179469
    [Abstract] [Full Text] [Related]

  • 15. Alterations of the AML1 transcription factor in human leukemia.
    Downing JR, Higuchi M, Lenny N, Yeoh AE.
    Semin Cell Dev Biol; 2000 Oct 26; 11(5):347-60. PubMed ID: 11105899
    [Abstract] [Full Text] [Related]

  • 16. Gatekeeper function of the RUNX1 transcription factor in acute leukemia.
    Niebuhr B, Fischer M, Täger M, Cammenga J, Stocking C.
    Blood Cells Mol Dis; 2008 Oct 26; 40(2):211-8. PubMed ID: 17920312
    [Abstract] [Full Text] [Related]

  • 17. LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation.
    Dai HP, Xue YQ, Zhou JW, Li AP, Wu YF, Pan JL, Wang Y, Zhang J.
    Genes Chromosomes Cancer; 2009 Dec 26; 48(12):1027-36. PubMed ID: 19760607
    [Abstract] [Full Text] [Related]

  • 18. Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells.
    Miller JD, Stacy T, Liu PP, Speck NA.
    Blood; 2001 Apr 15; 97(8):2248-56. PubMed ID: 11290585
    [Abstract] [Full Text] [Related]

  • 19. E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia.
    Pi WC, Wang J, Shimada M, Lin JW, Geng H, Lee YL, Lu R, Li D, Wang GG, Roeder RG, Chen WY.
    Blood; 2020 Jul 02; 136(1):11-23. PubMed ID: 32276273
    [Abstract] [Full Text] [Related]

  • 20. A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.
    Fu L, Shi J, Liu A, Zhou L, Jiang M, Fu H, Xu K, Li D, Deng A, Zhang Q, Pang Y, Guo Y, Hu K, Zhou J, Wang Y, Huang W, Jing Y, Dou L, Wang L, Xu K, Ke X, Nervi C, Li Y, Yu L.
    Int J Cancer; 2017 Feb 01; 140(3):653-661. PubMed ID: 27770540
    [Abstract] [Full Text] [Related]


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