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148 related items for PubMed ID: 20338198

  • 1. Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.
    Gomes FC, Ali NO, Brown E, Walker RG, Grant KM, Mottram JC.
    Mol Biochem Parasitol; 2010 Jun; 171(2):89-96. PubMed ID: 20338198
    [Abstract] [Full Text] [Related]

  • 2. The crk3 gene of Leishmania mexicana encodes a stage-regulated cdc2-related histone H1 kinase that associates with p12.
    Grant KM, Hassan P, Anderson JS, Mottram JC.
    J Biol Chem; 1998 Apr 24; 273(17):10153-9. PubMed ID: 9553063
    [Abstract] [Full Text] [Related]

  • 3. The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.
    Hassan P, Fergusson D, Grant KM, Mottram JC.
    Mol Biochem Parasitol; 2001 Apr 06; 113(2):189-98. PubMed ID: 11295173
    [Abstract] [Full Text] [Related]

  • 4. Molecular cloning, characterization and overexpression of a novel cyclin from Leishmania mexicana.
    Ali NO, Ibrahim ME, Grant KM, Mottram JC.
    Pak J Biol Sci; 2010 Aug 15; 13(16):775-84. PubMed ID: 21850927
    [Abstract] [Full Text] [Related]

  • 5. Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.
    Grant KM, Dunion MH, Yardley V, Skaltsounis AL, Marko D, Eisenbrand G, Croft SL, Meijer L, Mottram JC.
    Antimicrob Agents Chemother; 2004 Aug 15; 48(8):3033-42. PubMed ID: 15273118
    [Abstract] [Full Text] [Related]

  • 6. Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation.
    Duncan SM, Myburgh E, Philipon C, Brown E, Meissner M, Brewer J, Mottram JC.
    Mol Microbiol; 2016 Jun 15; 100(6):931-44. PubMed ID: 26991545
    [Abstract] [Full Text] [Related]

  • 7. Stage-specific activity of the Leishmania major CRK3 kinase and functional rescue of a Schizosaccharomyces pombe cdc2 mutant.
    Wang Y, Dimitrov K, Garrity LK, Sazer S, Beverley SM.
    Mol Biochem Parasitol; 1998 Oct 30; 96(1-2):139-50. PubMed ID: 9851613
    [Abstract] [Full Text] [Related]

  • 8. High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase.
    Walker RG, Thomson G, Malone K, Nowicki MW, Brown E, Blake DG, Turner NJ, Walkinshaw MD, Grant KM, Mottram JC.
    PLoS Negl Trop Dis; 2011 Apr 05; 5(4):e1033. PubMed ID: 21483720
    [Abstract] [Full Text] [Related]

  • 9. Leishmania mexicana: expression; characterization and activity assessment of E. coli-expressed recombinant CRK3.
    Ali NO, Ibrahim ME, Grant KM, Mottram JC.
    Eur Rev Med Pharmacol Sci; 2012 Oct 05; 16(10):1338-45. PubMed ID: 23104649
    [Abstract] [Full Text] [Related]

  • 10. Leishmania mexicana p12cks1, a homologue of fission yeast p13suc1, associates with a stage-regulated histone H1 kinase.
    Mottram JC, Grant KM.
    Biochem J; 1996 Jun 15; 316 ( Pt 3)(Pt 3):833-9. PubMed ID: 8670159
    [Abstract] [Full Text] [Related]

  • 11. Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi.
    Santori MI, Laría S, Gómez EB, Espinosa I, Galanti N, Téllez-Iñón MT.
    Mol Biochem Parasitol; 2002 May 15; 121(2):225-32. PubMed ID: 12034456
    [Abstract] [Full Text] [Related]

  • 12. Leishmania donovani cyclin 1 (LdCyc1) forms a complex with cell cycle kinase subunit CRK3 (LdCRK3) and is possibly involved in S-phase-related activities.
    Banerjee S, Sen A, Das P, Saha P.
    FEMS Microbiol Lett; 2006 Mar 15; 256(1):75-82. PubMed ID: 16487322
    [Abstract] [Full Text] [Related]

  • 13. A novel CDC2-related protein kinase from Leishmania mexicana, LmmCRK1, is post-translationally regulated during the life cycle.
    Mottram JC, Kinnaird JH, Shiels BR, Tait A, Barry JD.
    J Biol Chem; 1993 Oct 05; 268(28):21044-52. PubMed ID: 8407941
    [Abstract] [Full Text] [Related]

  • 14. Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.
    Gómez EB, Santori MI, Laría S, Engel JC, Swindle J, Eisen H, Szankasi P, Téllez-Iñón MT.
    Mol Biochem Parasitol; 2001 Mar 05; 113(1):97-108. PubMed ID: 11254958
    [Abstract] [Full Text] [Related]

  • 15. Cloning of a cdc2-related protein kinase from Trypanosoma cruzi that interacts with mammalian cyclins.
    Gómez EB, Kornblihtt AR, Téllez-Iñón MT.
    Mol Biochem Parasitol; 1998 Mar 15; 91(2):337-51. PubMed ID: 9580532
    [Abstract] [Full Text] [Related]

  • 16. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
    Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L.
    J Biol Chem; 2001 Jan 05; 276(1):251-60. PubMed ID: 11013232
    [Abstract] [Full Text] [Related]

  • 17. LmxPK4, a mitogen-activated protein kinase kinase homologue of Leishmania mexicana with a potential role in parasite differentiation.
    Kuhn D, Wiese M.
    Mol Microbiol; 2005 Jun 05; 56(5):1169-82. PubMed ID: 15882412
    [Abstract] [Full Text] [Related]

  • 18. The multiple roles of cyclin E1 in controlling cell cycle progression and cellular morphology of Trypanosoma brucei.
    Gourguechon S, Savich JM, Wang CC.
    J Mol Biol; 2007 May 11; 368(4):939-50. PubMed ID: 17376478
    [Abstract] [Full Text] [Related]

  • 19. LmxMPK4, an essential mitogen-activated protein kinase of Leishmania mexicana is phosphorylated and activated by the STE7-like protein kinase LmxMKK5.
    John von Freyend S, Rosenqvist H, Fink A, Melzer IM, Clos J, Jensen ON, Wiese M.
    Int J Parasitol; 2010 Jul 11; 40(8):969-78. PubMed ID: 20178803
    [Abstract] [Full Text] [Related]

  • 20. 6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis.
    Xingi E, Smirlis D, Myrianthopoulos V, Magiatis P, Grant KM, Meijer L, Mikros E, Skaltsounis AL, Soteriadou K.
    Int J Parasitol; 2009 Oct 11; 39(12):1289-303. PubMed ID: 19445946
    [Abstract] [Full Text] [Related]

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