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235 related items for PubMed ID: 20354186

  • 1. p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cells.
    Xiao D, Singh SV.
    Cancer Res; 2010 Apr 15; 70(8):3150-8. PubMed ID: 20354186
    [Abstract] [Full Text] [Related]

  • 2. D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.
    Sakao K, Singh SV.
    J Cell Biochem; 2012 Feb 15; 113(2):599-610. PubMed ID: 21956685
    [Abstract] [Full Text] [Related]

  • 3. Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.
    Xiao D, Powolny AA, Moura MB, Kelley EE, Bommareddy A, Kim SH, Hahm ER, Normolle D, Van Houten B, Singh SV.
    J Biol Chem; 2010 Aug 20; 285(34):26558-69. PubMed ID: 20571029
    [Abstract] [Full Text] [Related]

  • 4. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential.
    Xiao D, Lew KL, Zeng Y, Xiao H, Marynowski SW, Dhir R, Singh SV.
    Carcinogenesis; 2006 Nov 20; 27(11):2223-34. PubMed ID: 16774948
    [Abstract] [Full Text] [Related]

  • 5. Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.
    Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y, Singh SV.
    Cancer Res; 2009 Apr 15; 69(8):3704-12. PubMed ID: 19336571
    [Abstract] [Full Text] [Related]

  • 6. Propofol protects against angiotensin II-induced mouse hippocampal HT22 cells apoptosis via inhibition of p66Shc mitochondrial translocation.
    Zhu M, Chen J, Wen M, Sun Z, Sun X, Wang J, Miao C.
    Neuromolecular Med; 2014 Dec 15; 16(4):772-81. PubMed ID: 25151272
    [Abstract] [Full Text] [Related]

  • 7. The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.
    Natalicchio A, Tortosa F, Labarbuta R, Biondi G, Marrano N, Carchia E, Leonardini A, Cignarelli A, Bugliani M, Marchetti P, Fadini GP, Giorgio M, Avogaro A, Perrini S, Laviola L, Giorgino F.
    Diabetologia; 2015 Jun 15; 58(6):1260-71. PubMed ID: 25810038
    [Abstract] [Full Text] [Related]

  • 8. Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax.
    Xiao D, Zeng Y, Choi S, Lew KL, Nelson JB, Singh SV.
    Clin Cancer Res; 2005 Apr 01; 11(7):2670-9. PubMed ID: 15814648
    [Abstract] [Full Text] [Related]

  • 9. p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas.
    Lee MS, Igawa T, Chen SJ, Van Bemmel D, Lin JS, Lin FF, Johansson SL, Christman JK, Lin MF.
    Int J Cancer; 2004 Feb 20; 108(5):672-8. PubMed ID: 14696093
    [Abstract] [Full Text] [Related]

  • 10. Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species.
    Vikram A, Kim YR, Kumar S, Naqvi A, Hoffman TA, Kumar A, Miller FJ, Kim CS, Irani K.
    Arterioscler Thromb Vasc Biol; 2014 Oct 20; 34(10):2301-9. PubMed ID: 25147340
    [Abstract] [Full Text] [Related]

  • 11. Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells.
    Veeramani S, Igawa T, Yuan TC, Lin FF, Lee MS, Lin JS, Johansson SL, Lin MF.
    Oncogene; 2005 Nov 03; 24(48):7203-12. PubMed ID: 16170380
    [Abstract] [Full Text] [Related]

  • 12. Downregulated adaptor protein p66(Shc) mitigates autophagy process by low nutrient and enhances apoptotic resistance in human lung adenocarcinoma A549 cells.
    Zheng Z, Yang J, Zhao D, Gao D, Yan X, Yao Z, Liu Z, Ma Z.
    FEBS J; 2013 Sep 03; 280(18):4522-30. PubMed ID: 23815759
    [Abstract] [Full Text] [Related]

  • 13. The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism.
    Nemoto S, Combs CA, French S, Ahn BH, Fergusson MM, Balaban RS, Finkel T.
    J Biol Chem; 2006 Apr 14; 281(15):10555-60. PubMed ID: 16481327
    [Abstract] [Full Text] [Related]

  • 14. Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens.
    Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC.
    Mol Endocrinol; 2010 Oct 14; 24(10):2030-7. PubMed ID: 20685851
    [Abstract] [Full Text] [Related]

  • 15. Gene silencing of the mitochondrial adaptor p66(Shc) suppresses vascular hyperglycemic memory in diabetes.
    Paneni F, Mocharla P, Akhmedov A, Costantino S, Osto E, Volpe M, Lüscher TF, Cosentino F.
    Circ Res; 2012 Jul 20; 111(3):278-89. PubMed ID: 22693349
    [Abstract] [Full Text] [Related]

  • 16. Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo.
    Sakao K, Desineni S, Hahm ER, Singh SV.
    Prostate; 2012 Jul 01; 72(10):1104-16. PubMed ID: 22161756
    [Abstract] [Full Text] [Related]

  • 17. The silence of p66(Shc) in HCT8 cells inhibits the viability via PI3K/AKT/Mdm-2/p53 signaling pathway.
    Zhang L, Zhu S, Shi X, Sha W.
    Int J Clin Exp Pathol; 2015 Jul 01; 8(8):9097-104. PubMed ID: 26464652
    [Abstract] [Full Text] [Related]

  • 18. Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.
    Xiao D, Johnson CS, Trump DL, Singh SV.
    Mol Cancer Ther; 2004 May 01; 3(5):567-75. PubMed ID: 15141014
    [Abstract] [Full Text] [Related]

  • 19. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest.
    Chiao JW, Wu H, Ramaswamy G, Conaway CC, Chung FL, Wang L, Liu D.
    Carcinogenesis; 2004 Aug 01; 25(8):1403-8. PubMed ID: 15016658
    [Abstract] [Full Text] [Related]

  • 20. Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways.
    Akhmedov A, Montecucco F, Braunersreuther V, Camici GG, Jakob P, Reiner MF, Glanzmann M, Burger F, Paneni F, Galan K, Pelli G, Vuilleumier N, Belin A, Vallée JP, Mach F, Lüscher TF.
    Eur Heart J; 2015 Feb 21; 36(8):516-26a. PubMed ID: 25336219
    [Abstract] [Full Text] [Related]

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