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Journal Abstract Search

176 related items for PubMed ID: 20356977

  • 1. Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.
    Zeng L, Biernacka KM, Holly JM, Jarrett C, Morrison AA, Morgan A, Winters ZE, Foulstone EJ, Shield JP, Perks CM.
    Endocr Relat Cancer; 2010 Jun; 17(2):539-51. PubMed ID: 20356977
    [Abstract] [Full Text] [Related]

  • 2. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
    Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R.
    Int J Oncol; 2004 Mar; 24(3):591-608. PubMed ID: 14767544
    [Abstract] [Full Text] [Related]

  • 3. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
    Menendez JA, Ropero S, Mehmi I, Atlas E, Colomer R, Lupu R.
    Int J Oncol; 2004 Jun; 24(6):1369-83. PubMed ID: 15138577
    [Abstract] [Full Text] [Related]

  • 4. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells.
    Menendez JA, Lupu R.
    Int J Mol Med; 2005 Jan; 15(1):33-40. PubMed ID: 15583825
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis.
    Menendez JA, Colomer R, Lupu R.
    Med Hypotheses; 2005 Jan; 64(2):337-41. PubMed ID: 15607568
    [Abstract] [Full Text] [Related]

  • 6. Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells.
    Menendez JA, Vellon L, Lupu R.
    Med Hypotheses; 2005 Jan; 64(5):997-1001. PubMed ID: 15780499
    [Abstract] [Full Text] [Related]

  • 7. The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival.
    Menendez JA, Oza BP, Colomer R, Lupu R.
    Int J Oncol; 2005 Jun; 26(6):1507-15. PubMed ID: 15870863
    [Abstract] [Full Text] [Related]

  • 8. Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.
    Hardy S, Langelier Y, Prentki M.
    Cancer Res; 2000 Nov 15; 60(22):6353-8. PubMed ID: 11103797
    [Abstract] [Full Text] [Related]

  • 9. Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival.
    Chajès V, Cambot M, Moreau K, Lenoir GM, Joulin V.
    Cancer Res; 2006 May 15; 66(10):5287-94. PubMed ID: 16707454
    [Abstract] [Full Text] [Related]

  • 10. Theanaphthoquinone inhibits fatty acid synthase expression in EGF-stimulated human breast cancer cells via the regulation of EGFR/ErbB-2 signaling.
    Weng MS, Ho CT, Ho YS, Lin JK.
    Toxicol Appl Pharmacol; 2007 Jan 15; 218(2):107-18. PubMed ID: 17182072
    [Abstract] [Full Text] [Related]

  • 11. Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
    Bandyopadhyay S, Zhan R, Wang Y, Pai SK, Hirota S, Hosobe S, Takano Y, Saito K, Furuta E, Iiizumi M, Mohinta S, Watabe M, Chalfant C, Watabe K.
    Cancer Res; 2006 Jun 01; 66(11):5934-40. PubMed ID: 16740734
    [Abstract] [Full Text] [Related]

  • 12. Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene.
    Menendez JA, Vellon L, Oza BP, Lupu R.
    J Cell Biochem; 2005 Apr 01; 94(5):857-63. PubMed ID: 15669079
    [Abstract] [Full Text] [Related]

  • 13. Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells.
    Pizer ES, Wood FD, Pasternack GR, Kuhajda FP.
    Cancer Res; 1996 Feb 15; 56(4):745-51. PubMed ID: 8631008
    [Abstract] [Full Text] [Related]

  • 14. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.
    Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP.
    Cancer Res; 2000 Jan 15; 60(2):213-8. PubMed ID: 10667561
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells.
    Pizer ES, Jackisch C, Wood FD, Pasternack GR, Davidson NE, Kuhajda FP.
    Cancer Res; 1996 Jun 15; 56(12):2745-7. PubMed ID: 8665507
    [Abstract] [Full Text] [Related]

  • 16. Fatty acid metabolism in breast cancer cells: differential inhibitory effects of epigallocatechin gallate (EGCG) and C75.
    Puig T, Vázquez-Martín A, Relat J, Pétriz J, Menéndez JA, Porta R, Casals G, Marrero PF, Haro D, Brunet J, Colomer R.
    Breast Cancer Res Treat; 2008 Jun 15; 109(3):471-9. PubMed ID: 17902053
    [Abstract] [Full Text] [Related]

  • 17. Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.
    Pan MH, Lin CC, Lin JK, Chen WJ.
    J Agric Food Chem; 2007 Jun 27; 55(13):5030-7. PubMed ID: 17539658
    [Abstract] [Full Text] [Related]

  • 18. Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells.
    Menendez JA, Lupu R.
    Arch Immunol Ther Exp (Warsz); 2004 Jun 27; 52(6):414-26. PubMed ID: 15577743
    [Abstract] [Full Text] [Related]

  • 19. Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells.
    Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T, Kim EK, Vadlamudi A, Medghalchi SM, El Meskini R, Ronnett GV, Townsend CA, Kuhajda FP.
    Cancer Res; 2007 Apr 01; 67(7):2964-71. PubMed ID: 17409402
    [Abstract] [Full Text] [Related]

  • 20. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity.
    Thupari JN, Pinn ML, Kuhajda FP.
    Biochem Biophys Res Commun; 2001 Jul 13; 285(2):217-23. PubMed ID: 11444828
    [Abstract] [Full Text] [Related]

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