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493 related items for PubMed ID: 20391594

  • 1. Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.
    Leblanc A, Shiao TC, Roy R, Sleno L.
    Rapid Commun Mass Spectrom; 2010 May 15; 24(9):1241-50. PubMed ID: 20391594
    [Abstract] [Full Text] [Related]

  • 2. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.
    Soglia JR, Contillo LG, Kalgutkar AS, Zhao S, Hop CE, Boyd JG, Cole MJ.
    Chem Res Toxicol; 2006 Mar 15; 19(3):480-90. PubMed ID: 16544956
    [Abstract] [Full Text] [Related]

  • 3. Rapid screening of glutathione-trapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisition data mining.
    Ma L, Wen B, Ruan Q, Zhu M.
    Chem Res Toxicol; 2008 Jul 15; 21(7):1477-83. PubMed ID: 18549250
    [Abstract] [Full Text] [Related]

  • 4. Detection and structural characterization of glutathione-trapped reactive metabolites using liquid chromatography-high-resolution mass spectrometry and mass defect filtering.
    Zhu M, Ma L, Zhang H, Humphreys WG.
    Anal Chem; 2007 Nov 01; 79(21):8333-41. PubMed ID: 17918967
    [Abstract] [Full Text] [Related]

  • 5. Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites.
    Mutlib A, Lam W, Atherton J, Chen H, Galatsis P, Stolle W.
    Rapid Commun Mass Spectrom; 2005 Nov 01; 19(23):3482-92. PubMed ID: 16261644
    [Abstract] [Full Text] [Related]

  • 6. A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry.
    Lim HK, Chen J, Cook K, Sensenhauser C, Silva J, Evans DC.
    Rapid Commun Mass Spectrom; 2008 Apr 01; 22(8):1295-311. PubMed ID: 18383206
    [Abstract] [Full Text] [Related]

  • 7. Screening and identification of GSH-trapped reactive metabolites using hybrid triple quadruple linear ion trap mass spectrometry.
    Zheng J, Ma L, Xin B, Olah T, Humphreys WG, Zhu M.
    Chem Res Toxicol; 2007 May 01; 20(5):757-66. PubMed ID: 17402749
    [Abstract] [Full Text] [Related]

  • 8. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q, Zhu M.
    Chem Res Toxicol; 2010 May 17; 23(5):909-17. PubMed ID: 20297803
    [Abstract] [Full Text] [Related]

  • 9. Investigating the in vitro metabolism of fipexide: characterization of reactive metabolites using liquid chromatography/mass spectrometry.
    Sleno L, Staack RF, Varesio E, Hopfgartner G.
    Rapid Commun Mass Spectrom; 2007 May 17; 21(14):2301-11. PubMed ID: 17577876
    [Abstract] [Full Text] [Related]

  • 10. High-resolution chromatography/time-of-flight MSE with in silico data mining is an information-rich approach to reactive metabolite screening.
    Barbara JE, Castro-Perez JM.
    Rapid Commun Mass Spectrom; 2011 Oct 30; 25(20):3029-40. PubMed ID: 21953957
    [Abstract] [Full Text] [Related]

  • 11. Stable-isotope trapping and high-throughput screenings of reactive metabolites using the isotope MS signature.
    Yan Z, Caldwell GW.
    Anal Chem; 2004 Dec 01; 76(23):6835-47. PubMed ID: 15571331
    [Abstract] [Full Text] [Related]

  • 12. High-throughput screening for glutathione conjugates using stable-isotope labeling and negative electrospray ionization precursor-ion mass spectrometry.
    Liao S, Ewing NP, Boucher B, Materne O, Brummel CL.
    Rapid Commun Mass Spectrom; 2012 Mar 30; 26(6):659-69. PubMed ID: 22328220
    [Abstract] [Full Text] [Related]

  • 13. Unbiased high-throughput screening of reactive metabolites on the linear ion trap mass spectrometer using polarity switch and mass tag triggered data-dependent acquisition.
    Yan Z, Caldwell GW, Maher N.
    Anal Chem; 2008 Aug 15; 80(16):6410-22. PubMed ID: 18642850
    [Abstract] [Full Text] [Related]

  • 14. Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
    Madsen KG, Olsen J, Skonberg C, Hansen SH, Jurva U.
    Chem Res Toxicol; 2007 May 15; 20(5):821-31. PubMed ID: 17447796
    [Abstract] [Full Text] [Related]

  • 15. Enhanced screening of glutathione-trapped reactive metabolites by in-source collision-induced dissociation and extraction of product ion using UHPLC-high resolution mass spectrometry.
    Zhu X, Kalyanaraman N, Subramanian R.
    Anal Chem; 2011 Dec 15; 83(24):9516-23. PubMed ID: 22077671
    [Abstract] [Full Text] [Related]

  • 16. Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry.
    Rousu T, Pelkonen O, Tolonen A.
    Rapid Commun Mass Spectrom; 2009 Mar 15; 23(6):843-55. PubMed ID: 19224530
    [Abstract] [Full Text] [Related]

  • 17. An accurate-mass-based spectral-averaging isotope-pattern-filtering algorithm for extraction of drug metabolites possessing a distinct isotope pattern from LC-MS data.
    Zhu P, Tong W, Alton K, Chowdhury S.
    Anal Chem; 2009 Jul 15; 81(14):5910-7. PubMed ID: 19518135
    [Abstract] [Full Text] [Related]

  • 18. Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography-mass spectrometry to screen and characterize reactive drug metabolites.
    Defoy D, Dansette PM, Neugebauer W, Wagner JR, Klarskov K.
    Chem Res Toxicol; 2011 Mar 21; 24(3):412-7. PubMed ID: 21375241
    [Abstract] [Full Text] [Related]

  • 19. Fluorescence-based liver microsomal assay for screening of pharmaceutical reactive metabolites using a glutathione conjugated 96-well plate.
    Ma X, Chan EC.
    Bioconjug Chem; 2010 Jan 21; 21(1):46-55. PubMed ID: 19957910
    [Abstract] [Full Text] [Related]

  • 20. Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.
    Damsten MC, van Vugt-Lussenburg BM, Zeldenthuis T, de Vlieger JS, Commandeur JN, Vermeulen NP.
    Chem Biol Interact; 2008 Jan 10; 171(1):96-107. PubMed ID: 17996858
    [Abstract] [Full Text] [Related]

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